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EXPRESSION OF A 65 KDA ONCOFETAL PHOSPHOPROTEIN IN THE ALTERED HEPATIC FOCI OF RATS FED 2-ACETYLAMINOFLUORENE FOLLOWED BY PHENOBARBITAL

  • Authors:
    • M DELRIO
    • M HANAUSEK
    • Z WALASZEK
    • G STOICA

  • View Affiliations

  • Published online on: August 1, 1994     https://doi.org/10.3892/ijo.5.2.259
  • Pages: 259-265
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Abstract

The altered hepatic foci (AHF) developed in livers of Sprague-Dawley male rats,by acetylaminofluorene/phenobarbital protocol, were analyzed on paraffin sections for gamma-glutamyl-transpeptidase, glutathione S-transferase P and 65 kDa oncofetal protein (p65). 92% percent of the foci were GST-P-positive, 89% of those were also positive for GGT but only 10-12% were positive for p65. Comparison of tissues from different sources such as fetal and normal liver, foci, nodules, surrounding parenchyma and hepatocellular carcinomas revealed the presence of p65 protein in all tissues except normal rat liver and liver parenchyma surrounding the focal lesions.

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August 1994
Volume 5 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
DELRIO M, HANAUSEK M, WALASZEK Z and STOICA G: EXPRESSION OF A 65 KDA ONCOFETAL PHOSPHOPROTEIN IN THE ALTERED HEPATIC FOCI OF RATS FED 2-ACETYLAMINOFLUORENE FOLLOWED BY PHENOBARBITAL. Int J Oncol 5: 259-265, 1994.
APA
DELRIO, M., HANAUSEK, M., WALASZEK, Z., & STOICA, G. (1994). EXPRESSION OF A 65 KDA ONCOFETAL PHOSPHOPROTEIN IN THE ALTERED HEPATIC FOCI OF RATS FED 2-ACETYLAMINOFLUORENE FOLLOWED BY PHENOBARBITAL. International Journal of Oncology, 5, 259-265. https://doi.org/10.3892/ijo.5.2.259
MLA
DELRIO, M., HANAUSEK, M., WALASZEK, Z., STOICA, G."EXPRESSION OF A 65 KDA ONCOFETAL PHOSPHOPROTEIN IN THE ALTERED HEPATIC FOCI OF RATS FED 2-ACETYLAMINOFLUORENE FOLLOWED BY PHENOBARBITAL". International Journal of Oncology 5.2 (1994): 259-265.
Chicago
DELRIO, M., HANAUSEK, M., WALASZEK, Z., STOICA, G."EXPRESSION OF A 65 KDA ONCOFETAL PHOSPHOPROTEIN IN THE ALTERED HEPATIC FOCI OF RATS FED 2-ACETYLAMINOFLUORENE FOLLOWED BY PHENOBARBITAL". International Journal of Oncology 5, no. 2 (1994): 259-265. https://doi.org/10.3892/ijo.5.2.259