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ANTI-CD3 AND ANTI-CD16 MONOCLONAL-ANTIBODY IN-VITRO ENHANCEMENT OF NK ACTIVITY IN PBL FROM GASTROINTESTINAL-TRACT CANCER-PATIENTS

  • Authors:
    • RE CATTERICK
    • J HOLLINGWORTH
    • T HORSBURGH
    • PS VEITCH
    • PRF BELL
    • RFL JAMES

  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.683
  • Pages: 683-688
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Abstract

Natural killer (NK) cell cytotoxicity was assessed using peripheral blood mononuclear cells from 103 healthy volunteers and 51 cancer patients. Peripheral blood cells were assessed by flow cytometry, and cytotoxicity in a standard 4-hour Cr-51-release assay using K562 cells as targets. Anti-CD3 and anti-CD16 mAb significantly enhanced cytoxicity in vitro. NK cell numbers correlated with levels of cytotoxicity. Patients with liver metastases had significantly more CD3+ lymphocytes coexpressing NK markers than patients without liver involvement. These CD3+ NK cells may also mediate cytotoxicity. Enhancement of cellular cytotoxicity by anti-CD3 and anti-CD16 may be of use in cancer immunotherapy protocols.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
CATTERICK R, HOLLINGWORTH J, HORSBURGH T, VEITCH P, BELL P and JAMES R: ANTI-CD3 AND ANTI-CD16 MONOCLONAL-ANTIBODY IN-VITRO ENHANCEMENT OF NK ACTIVITY IN PBL FROM GASTROINTESTINAL-TRACT CANCER-PATIENTS. Int J Oncol 5: 683-688, 1994.
APA
CATTERICK, R., HOLLINGWORTH, J., HORSBURGH, T., VEITCH, P., BELL, P., & JAMES, R. (1994). ANTI-CD3 AND ANTI-CD16 MONOCLONAL-ANTIBODY IN-VITRO ENHANCEMENT OF NK ACTIVITY IN PBL FROM GASTROINTESTINAL-TRACT CANCER-PATIENTS. International Journal of Oncology, 5, 683-688. https://doi.org/10.3892/ijo.5.3.683
MLA
CATTERICK, R., HOLLINGWORTH, J., HORSBURGH, T., VEITCH, P., BELL, P., JAMES, R."ANTI-CD3 AND ANTI-CD16 MONOCLONAL-ANTIBODY IN-VITRO ENHANCEMENT OF NK ACTIVITY IN PBL FROM GASTROINTESTINAL-TRACT CANCER-PATIENTS". International Journal of Oncology 5.3 (1994): 683-688.
Chicago
CATTERICK, R., HOLLINGWORTH, J., HORSBURGH, T., VEITCH, P., BELL, P., JAMES, R."ANTI-CD3 AND ANTI-CD16 MONOCLONAL-ANTIBODY IN-VITRO ENHANCEMENT OF NK ACTIVITY IN PBL FROM GASTROINTESTINAL-TRACT CANCER-PATIENTS". International Journal of Oncology 5, no. 3 (1994): 683-688. https://doi.org/10.3892/ijo.5.3.683