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EXPRESSION OF MATRIX METALLOPROTEINASE-2 (MMP-2) IN CERVICAL NEOPLASIA - IMMUNOHISTOCHEMICAL AND IN-SITU HYBRIDIZATION STUDIES

  • Authors:
    • S OTA
    • Y MIYAJIMA
    • A NAKASHIMA
    • M MORIMATSU
    • M YAKUSHIJI

  • View Affiliations

  • Published online on: December 1, 1994     https://doi.org/10.3892/ijo.5.6.1301
  • Pages: 1301-1304
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The expression of matrix metalloproteinase-2 (MMP-2, type IV collagenase, 72 kDa) in 47 cervical precancerous and cancerous lesions were localised by in situ hybridization and immunohistochemical studies. MMP-2 mRNA was present in the stromal cells surrounding invasive cells in the majority of squamous cell carcinomas and adenocarcinomas. In contrast, MMP-2 immunoreactivity was found in the epithelial cells. Our results indicate that there may be some interaction between carcinoma cells and stromal cells to produce MMP-2 which may contribute to the destruction of the extracellular matrix in invasive cervical carcinomas.

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December 1994
Volume 5 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
OTA S, MIYAJIMA Y, NAKASHIMA A, MORIMATSU M and YAKUSHIJI M: EXPRESSION OF MATRIX METALLOPROTEINASE-2 (MMP-2) IN CERVICAL NEOPLASIA - IMMUNOHISTOCHEMICAL AND IN-SITU HYBRIDIZATION STUDIES. Int J Oncol 5: 1301-1304, 1994.
APA
OTA, S., MIYAJIMA, Y., NAKASHIMA, A., MORIMATSU, M., & YAKUSHIJI, M. (1994). EXPRESSION OF MATRIX METALLOPROTEINASE-2 (MMP-2) IN CERVICAL NEOPLASIA - IMMUNOHISTOCHEMICAL AND IN-SITU HYBRIDIZATION STUDIES. International Journal of Oncology, 5, 1301-1304. https://doi.org/10.3892/ijo.5.6.1301
MLA
OTA, S., MIYAJIMA, Y., NAKASHIMA, A., MORIMATSU, M., YAKUSHIJI, M."EXPRESSION OF MATRIX METALLOPROTEINASE-2 (MMP-2) IN CERVICAL NEOPLASIA - IMMUNOHISTOCHEMICAL AND IN-SITU HYBRIDIZATION STUDIES". International Journal of Oncology 5.6 (1994): 1301-1304.
Chicago
OTA, S., MIYAJIMA, Y., NAKASHIMA, A., MORIMATSU, M., YAKUSHIJI, M."EXPRESSION OF MATRIX METALLOPROTEINASE-2 (MMP-2) IN CERVICAL NEOPLASIA - IMMUNOHISTOCHEMICAL AND IN-SITU HYBRIDIZATION STUDIES". International Journal of Oncology 5, no. 6 (1994): 1301-1304. https://doi.org/10.3892/ijo.5.6.1301