DIFFERENTIAL EXPRESSION OF HSP90, GELSOLIN AND GST-PI IN HUMAN GASTRIC-CARCINOMA CELL-LINES
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- Published online on: December 1, 1994 https://doi.org/10.3892/ijo.5.6.1347
- Pages: 1347-1351
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Abstract
We have analyzed proteins produced in Various human gastric carcinoma cell lines and normal gastric mucosa. The production of HSP90 increased in eight gastric carcinoma cell lines. Gelsolin content was down-regulated in seven gastric carcinoma cell lines. Furthermore, the production of GST-pi increased in a poorly differentiated adenocarcinoma cell line and two scirrhous gastric carcinoma cell lines. These results suggest that increased production of HSP90 and down-regulation of gelsolin play an important role in gastric carcinogenesis, and that abundant production of GST-pi is related to unique behavior of some scirrhous gastric carcinomas.
