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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1995 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1995 Volume 6 Issue 1

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Article

HIGH-FREQUENCY OF LOSS OF EXPRESSION AND ALLELIC DELETION OF THE APC AND MCC GENES IN HUMAN PROSTATE-CANCER

  • Authors:
    • X GAO
    • A ZACHAREK
    • D GRIGNON
    • H LIU
    • W SAKR
    • AT PORTER
    • YQ CHEN
    • KV HONN

  • View Affiliations / Copyright

    Affiliations: WAYNE STATE UNIV,SCH MED,DEPT PATHOL,DETROIT,MI 48201. WAYNE STATE UNIV,DEPT CHEM,DETROIT,MI 48201. WAYNE STATE UNIV,SCH MED,DEPT RADIAT ONCOL,DIV CANC BIOL,DETROIT,MI 48201.
  • Pages: 111-117
    |
    Published online on: January 1, 1995
       https://doi.org/10.3892/ijo.6.1.111
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Abstract

Loss of heterozygosity (LOH) or allelic deletion at various loci has been reported in the majority of human tumors. The frequently deleted targets are believed to be tumor suppressor genes. Recent studies have identified the APC and MCC genes at 5q21, as putative tumor suppressor genes. The APC and MCC genes have been implicated in the development of familial adenomatous polyposis coli and cancers of the gastrointestinal tract, ovary, breast and lung. In the present study, we investigated a possible role of the APC and MCC genes in prostate cancer development. mRNA expression of the APC and MCC genes and LOH at the APC and MCC loci were determined in prostate cancer tissues from 28 patients and 5 human prostatic adenocarcinoma cell lines. Of the informative cases, the frequency of LOH at the APC and MCC loci was 63% (10/16) and 54% (7/13), respectively. Overall, 65% (15/23) of the informative cases showed LOH at the APC and/or MCC gene. All prostate cancer cell lines showed homozygosity at all APC and MCC polymorphic sites studied. Approximately half (57%) of the tumor tissues examined showed a decreased expression of APC and MCC mRNA. Our data suggest that the APC and MCC genes may be involved in the formation of human prostate cancer (HPC).

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Copy and paste a formatted citation
Spandidos Publications style
GAO X, ZACHAREK A, GRIGNON D, LIU H, SAKR W, PORTER A, CHEN Y and HONN K: HIGH-FREQUENCY OF LOSS OF EXPRESSION AND ALLELIC DELETION OF THE APC AND MCC GENES IN HUMAN PROSTATE-CANCER. Int J Oncol 6: 111-117, 1995.
APA
GAO, X., ZACHAREK, A., GRIGNON, D., LIU, H., SAKR, W., PORTER, A. ... HONN, K. (1995). HIGH-FREQUENCY OF LOSS OF EXPRESSION AND ALLELIC DELETION OF THE APC AND MCC GENES IN HUMAN PROSTATE-CANCER. International Journal of Oncology, 6, 111-117. https://doi.org/10.3892/ijo.6.1.111
MLA
GAO, X., ZACHAREK, A., GRIGNON, D., LIU, H., SAKR, W., PORTER, A., CHEN, Y., HONN, K."HIGH-FREQUENCY OF LOSS OF EXPRESSION AND ALLELIC DELETION OF THE APC AND MCC GENES IN HUMAN PROSTATE-CANCER". International Journal of Oncology 6.1 (1995): 111-117.
Chicago
GAO, X., ZACHAREK, A., GRIGNON, D., LIU, H., SAKR, W., PORTER, A., CHEN, Y., HONN, K."HIGH-FREQUENCY OF LOSS OF EXPRESSION AND ALLELIC DELETION OF THE APC AND MCC GENES IN HUMAN PROSTATE-CANCER". International Journal of Oncology 6, no. 1 (1995): 111-117. https://doi.org/10.3892/ijo.6.1.111
Copy and paste a formatted citation
x
Spandidos Publications style
GAO X, ZACHAREK A, GRIGNON D, LIU H, SAKR W, PORTER A, CHEN Y and HONN K: HIGH-FREQUENCY OF LOSS OF EXPRESSION AND ALLELIC DELETION OF THE APC AND MCC GENES IN HUMAN PROSTATE-CANCER. Int J Oncol 6: 111-117, 1995.
APA
GAO, X., ZACHAREK, A., GRIGNON, D., LIU, H., SAKR, W., PORTER, A. ... HONN, K. (1995). HIGH-FREQUENCY OF LOSS OF EXPRESSION AND ALLELIC DELETION OF THE APC AND MCC GENES IN HUMAN PROSTATE-CANCER. International Journal of Oncology, 6, 111-117. https://doi.org/10.3892/ijo.6.1.111
MLA
GAO, X., ZACHAREK, A., GRIGNON, D., LIU, H., SAKR, W., PORTER, A., CHEN, Y., HONN, K."HIGH-FREQUENCY OF LOSS OF EXPRESSION AND ALLELIC DELETION OF THE APC AND MCC GENES IN HUMAN PROSTATE-CANCER". International Journal of Oncology 6.1 (1995): 111-117.
Chicago
GAO, X., ZACHAREK, A., GRIGNON, D., LIU, H., SAKR, W., PORTER, A., CHEN, Y., HONN, K."HIGH-FREQUENCY OF LOSS OF EXPRESSION AND ALLELIC DELETION OF THE APC AND MCC GENES IN HUMAN PROSTATE-CANCER". International Journal of Oncology 6, no. 1 (1995): 111-117. https://doi.org/10.3892/ijo.6.1.111
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