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ANALYSES OF LINKAGE TO 17Q11-Q23 IN 3 FRENCH HEREDITARY NONPOLYPOSIS COLON-CANCER FAMILIES

  • Authors:
    • D BERNARD-GALLON
    • S GOSSE
    • L ESSIOUX
    • P LAURENTPUIG
    • C RALLIERE
    • H CURE
    • JO BAY
    • S SCHRAUB
    • C BONAITI-PELLIE
    • H SOBOL
    • YJ BIGNON

  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/ijo.6.3.693
  • Pages: 693-697
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Abstract

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, accounting for approximately 6% of colorectal cancers. We performed linkage analyses with the aim of proving or excluding the existence of a susceptibility locus on 17q. Three HNPCC families (102 collected members, 25 colorectal cancers, 9 other cancers and 6 colorectal adenomas) were studied with 7 polymorphic DNA markers Mfd15, THRA 1, D17S800, D17S855, Mfd 188, 42D6, 46E6 localized in the 17q11-q23 region. After in vitro enzymatic amplification, the different alleles were separated by classic vertical poly-acrylamide gel electrophoresis or analyzed with the automatic sequencing machine 373A (Applied Biosystems). Results showed that none of the 7 studied markers of the chromosome 17q were linked to the HNPCC disease.

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March 1995
Volume 6 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
BERNARD-GALLON D, GOSSE S, ESSIOUX L, LAURENTPUIG P, RALLIERE C, CURE H, BAY J, SCHRAUB S, BONAITI-PELLIE C, SOBOL H, SOBOL H, et al: ANALYSES OF LINKAGE TO 17Q11-Q23 IN 3 FRENCH HEREDITARY NONPOLYPOSIS COLON-CANCER FAMILIES. Int J Oncol 6: 693-697, 1995.
APA
BERNARD-GALLON, D., GOSSE, S., ESSIOUX, L., LAURENTPUIG, P., RALLIERE, C., CURE, H. ... BIGNON, Y. (1995). ANALYSES OF LINKAGE TO 17Q11-Q23 IN 3 FRENCH HEREDITARY NONPOLYPOSIS COLON-CANCER FAMILIES. International Journal of Oncology, 6, 693-697. https://doi.org/10.3892/ijo.6.3.693
MLA
BERNARD-GALLON, D., GOSSE, S., ESSIOUX, L., LAURENTPUIG, P., RALLIERE, C., CURE, H., BAY, J., SCHRAUB, S., BONAITI-PELLIE, C., SOBOL, H., BIGNON, Y."ANALYSES OF LINKAGE TO 17Q11-Q23 IN 3 FRENCH HEREDITARY NONPOLYPOSIS COLON-CANCER FAMILIES". International Journal of Oncology 6.3 (1995): 693-697.
Chicago
BERNARD-GALLON, D., GOSSE, S., ESSIOUX, L., LAURENTPUIG, P., RALLIERE, C., CURE, H., BAY, J., SCHRAUB, S., BONAITI-PELLIE, C., SOBOL, H., BIGNON, Y."ANALYSES OF LINKAGE TO 17Q11-Q23 IN 3 FRENCH HEREDITARY NONPOLYPOSIS COLON-CANCER FAMILIES". International Journal of Oncology 6, no. 3 (1995): 693-697. https://doi.org/10.3892/ijo.6.3.693