INDUCTION OF APOPTOSIS IN HEAD AND NECK TUMOR-CELL LINES BY ANTI-FAS ANTIBODY

  • Authors:
    • H KUMAZAWA
    • T TACHIKAWA
    • SI SAI
    • T YAMASHITA
    • K KAWAMOTO
    • T OYAIZU
    • A TSUBURA
  • View Affiliations

  • Published online on: April 1, 1995     https://doi.org/10.3892/ijo.6.4.753
  • Pages: 753-758
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Programmed cell death, currently termed apoptosis plays a key role in the maintenance of the steady state in continuously renewing tissues. Since little is known of apoptosis in head and neck tumors, we studied morphological changes in head and neck tumor-derived cell lines (KB, KBrc, HSC-2,3,4), induced by anti-Fas antibody. Light and electron microscopic examinations were carried out after culturing these cell lines with the antibody for 1-2 days. The antitumor effect of anti-Fas antibody on tumor cells differed with the cell lines. Most of the cell lines that were sensitive to anti-Pas antibody showed evidence of enhanced apoptosis when the cells were pretreated with interferon-gamma. The results suggest that the strategy of induction of apoptosis by anti-Fas antibody may be considered in treatment of some tumors of head and neck.

Related Articles

Journal Cover

April 1995
Volume 6 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
KUMAZAWA H, TACHIKAWA T, SAI S, YAMASHITA T, KAWAMOTO K, OYAIZU T and TSUBURA A: INDUCTION OF APOPTOSIS IN HEAD AND NECK TUMOR-CELL LINES BY ANTI-FAS ANTIBODY. Int J Oncol 6: 753-758, 1995.
APA
KUMAZAWA, H., TACHIKAWA, T., SAI, S., YAMASHITA, T., KAWAMOTO, K., OYAIZU, T., & TSUBURA, A. (1995). INDUCTION OF APOPTOSIS IN HEAD AND NECK TUMOR-CELL LINES BY ANTI-FAS ANTIBODY. International Journal of Oncology, 6, 753-758. https://doi.org/10.3892/ijo.6.4.753
MLA
KUMAZAWA, H., TACHIKAWA, T., SAI, S., YAMASHITA, T., KAWAMOTO, K., OYAIZU, T., TSUBURA, A."INDUCTION OF APOPTOSIS IN HEAD AND NECK TUMOR-CELL LINES BY ANTI-FAS ANTIBODY". International Journal of Oncology 6.4 (1995): 753-758.
Chicago
KUMAZAWA, H., TACHIKAWA, T., SAI, S., YAMASHITA, T., KAWAMOTO, K., OYAIZU, T., TSUBURA, A."INDUCTION OF APOPTOSIS IN HEAD AND NECK TUMOR-CELL LINES BY ANTI-FAS ANTIBODY". International Journal of Oncology 6, no. 4 (1995): 753-758. https://doi.org/10.3892/ijo.6.4.753