OF/LB COLLAGEN PROMOTES CHEMOINVASION OF BREAST-CANCER CELLS AND DIRECTS EPITHELIAL-CELL MIGRATION INTO GRANULATION-TISSUE OF EXPERIMENTAL DERMAL WOUNDS
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- Published online on: May 1, 1995 https://doi.org/10.3892/ijo.6.5.1015
- Pages: 1015-1020
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Abstract
OF/LB collagen is a recently described once-fetal form of collagen, with laminin-binding properties, composed of three alpha(1)(I)-sized chains, one of which displaying an unusually acidic pI. This collagen appears able to direct the migration of breast cancer cells through Matrigel, and of injury-activated epithelial cells into the underlying granulation stromal tissue. The effect exerted by OF/LB collagen in vitro appears preferentially linked to its acidic chain. The data reported strongly support the hypothesis that the presence and accumulation of OF/LB collagen in cancer may play a fundamental role in the invasive growth.