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PRODUCTION OF TGF-BETA AND HGF RECEPTOR BY A DIFFERENTIATED PAPILLARY THYROID-CARCINOMA CELL-LINE (B-CPAP) - IMPLICATION IN MALIGNANCY

  • Authors:
    • C PAULIN
    • O AVALLET
    • F TARDY
    • J SAEZ
    • A FUSCO
    • N FABIEN

  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/ijo.7.3.657
  • Pages: 657-660
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Abstract

The B-CPAP cell line was obtained from a human differentiated papillary thyroid carcinoma. Previous studies showed that the cells present thyroid characteristics such as thyroglobulin production, phenotypic alterations such as synthesis of human chorionic gonadotropin hormone (HCG), expression of neuron specific enolase (NSE) and protein S100, and also somatic mutations of p53 and K-rns oncogenes. The present data further characterize this cell line and show an overexpression of transforming growth factor (TGF beta 1) and c-met gene product i.e. the receptor for human growth factor (HGF). The relation between the phenotypic and somatic alterations in the process of malignancy are discussed.

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September 1995
Volume 7 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
PAULIN C, AVALLET O, TARDY F, SAEZ J, FUSCO A and FABIEN N: PRODUCTION OF TGF-BETA AND HGF RECEPTOR BY A DIFFERENTIATED PAPILLARY THYROID-CARCINOMA CELL-LINE (B-CPAP) - IMPLICATION IN MALIGNANCY. Int J Oncol 7: 657-660, 1995.
APA
PAULIN, C., AVALLET, O., TARDY, F., SAEZ, J., FUSCO, A., & FABIEN, N. (1995). PRODUCTION OF TGF-BETA AND HGF RECEPTOR BY A DIFFERENTIATED PAPILLARY THYROID-CARCINOMA CELL-LINE (B-CPAP) - IMPLICATION IN MALIGNANCY. International Journal of Oncology, 7, 657-660. https://doi.org/10.3892/ijo.7.3.657
MLA
PAULIN, C., AVALLET, O., TARDY, F., SAEZ, J., FUSCO, A., FABIEN, N."PRODUCTION OF TGF-BETA AND HGF RECEPTOR BY A DIFFERENTIATED PAPILLARY THYROID-CARCINOMA CELL-LINE (B-CPAP) - IMPLICATION IN MALIGNANCY". International Journal of Oncology 7.3 (1995): 657-660.
Chicago
PAULIN, C., AVALLET, O., TARDY, F., SAEZ, J., FUSCO, A., FABIEN, N."PRODUCTION OF TGF-BETA AND HGF RECEPTOR BY A DIFFERENTIATED PAPILLARY THYROID-CARCINOMA CELL-LINE (B-CPAP) - IMPLICATION IN MALIGNANCY". International Journal of Oncology 7, no. 3 (1995): 657-660. https://doi.org/10.3892/ijo.7.3.657