A PHASE-II STUDY TESTING A COMBINATION CHEMOTHERAPY WITH EPIRUBICIN AND VINDESINE AS 2ND LINE TREATMENT FOR PATIENTS WITH ADVANCED NON-SMALL-CELL LUNG-CANCER
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- Published online on: November 1, 1995 https://doi.org/10.3892/ijo.7.5.1175
- Pages: 1175-1178
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Abstract
The European Lung Cancer Working Party conducted a phase II trial to determine the activity of a salvage regimen with high dose epirubicin (120 mg/m(2) on day 1) and vindesine (3 mg/m(2) on day 1) in patients with advanced non-small cell lung cancer failing to respond to first-line chemotherapy containing cisplatin and/or carboplatin. Courses were repeated every 3 weeks and evaluation of antitumoral response was performed after the 2 first courses. A total of 53 patients were registered, 4 were not eligible and 42 were evaluable for response. Two (5%) objective responses were documented. Although the regimen was very well tolerated, based oh the results it has to be considered inactive.