PREVALENCE OF P53 OVEREXPRESSION OR MUTATIONS, BUT NOT K-RAS MUTATIONS, IN RECURRENT PATIENTS AFFECTED BY COLORECTAL-CARCINOMA
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- Published online on: December 1, 1995 https://doi.org/10.3892/ijo.7.6.1319
- Pages: 1319-1325
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Abstract
In order to establish prognostic indicators of poor clinical evolution in colorectal cancer, we have studied p53 abnormalities and K-ras mutations in 65 patients affected by colorectal carcinoma who had undergone radical surgery. A single event of p53 protein overexpression or p53 mutation, but not K-ras mutation, was significantly prevalent in recurrent tumors. A double event of K-ras mutation and p53 protein overexpression was prevalent in patients showing Dukes' stage C, but showed a lack of prevalence in patients who recurred. The presence of p53 protein overexpression does not assure an underlying mutation in colorectal carcinoma.
