Expression of Fas and anti-Fas-mediated apoptosis in human renal cell carcinoma
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- Published online on: July 1, 1996 https://doi.org/10.3892/ijo.9.1.49
- Pages: 49-56
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Abstract
We investigated Fas expression and Fas-mediated apoptosis on 25 surgically resected renal cell carcinoma (RCC) tissues and 8 RCC cell lines. Immunohistochemistry demonstrated that cancer cells in the 25 tissues expressed Fas (100%). Fas expression was confirmed in all cell lines at protein and mRNA levels, but the 7 cell lines were resistant or low sensitive to anti-Fas induced apoptosis. In addition, cancer cells in all of the RCC tissues and all cell lines expressed an anti-apoptotic proto-oncogene, bcl-2 product. In conclusion, i) Fas/Fas-ligand system may be often impaired in RCCs despite their frequent expression; and ii) their frequent Bcl-2 expression may further contribute to the resistance to various apoptotic stimuli.
