DCC gene alterations in histological types and clinical stages of epithelial ovarian cancer

Yamashita,T; Yaginuma,Y; Yamashita,K; Fujita,M; Ishikawa,M

doi:10.3892/ijo.9.2.291

DCC gene alterations in histological types and clinical stages of epithelial ovarian cancer

Authors:
- T Yamashita
- Y Yaginuma
- K Yamashita
- M Fujita
- M Ishikawa
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Affiliations: NATL SAPPORO HOSP,DEPT OBSTET & GYNECOL,SHIROISHI KU,SAPPORO,HOKKAIDO 003,JAPAN. NATL SAPPORO HOSP,DEPT PATHOL,SHIROISHI KU,SAPPORO,HOKKAIDO 003,JAPAN.
Published online on: August 1, 1996 https://doi.org/10.3892/ijo.9.2.291
Pages: 291-296

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Abstract

We examined loss of heterozygosity (LOH) and mRNA expression of the DCC gene in 77 tissues and 6 cell lines of human ovarian cancer. LOH was seen in serous and endometrioid adenocarcinomas but was not in clear cell and mucinous adenocarcinomas. LOH was exhibited in all clinical stages including stage I. In the DCC mRNA expression, 6 of 9 (66.7%) cancer tissues and all of 6 (100%) cancer cell lines showed loss or marked reduction. These results suggest that alterations of the DCC gene may play important roles in the pathway of carcinogenesis of human ovarian cancer, especially serous and endometrioid adenocarcinomas.