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The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma

  • Authors:
    • Jun Yu
    • Etmar Bulk
    • Ping Ji
    • Antje Hascher
    • Steffen Koschmieder
    • Wolfgang E. Berdel
    • Carsten Müller-Tidow

  • View Affiliations

  • Published online on: July 1, 2009     https://doi.org/10.3892/ijo_00000326
  • Pages: 175-179
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Abstract

Decreased expression levels of EPHB6, a member of the receptor tyrosine kinases (RTKs), are associated with an increased risk of metastasis development in early stage non-small cell lung cancer (NSCLC). However, the signaling properties of the kinase-defective EPHB6 receptor are not well-understood. Here, we show that expression of EPHB6 in A549 lung adenocarinoma cells led to phosphorylation of the MAP kinase ERK. Conversely, siRNA based knockdown of EPHB6 reversed ERK phosphorylation. Intriguingly, EPHB6-induced phosphorylation of ERK was uncoupled by activation of the Elk-1 transcriptional factor. These analyses suggest that kinase defective EPHB6 can lead to MAPK activation.

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Journal Cover

July 2009
Volume 35 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Yu J, Bulk E, Ji P, Hascher A, Koschmieder S, Berdel WE and Müller-Tidow C: The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. Int J Oncol 35: 175-179, 2009.
APA
Yu, J., Bulk, E., Ji, P., Hascher, A., Koschmieder, S., Berdel, W.E., & Müller-Tidow, C. (2009). The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. International Journal of Oncology, 35, 175-179. https://doi.org/10.3892/ijo_00000326
MLA
Yu, J., Bulk, E., Ji, P., Hascher, A., Koschmieder, S., Berdel, W. E., Müller-Tidow, C."The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma". International Journal of Oncology 35.1 (2009): 175-179.
Chicago
Yu, J., Bulk, E., Ji, P., Hascher, A., Koschmieder, S., Berdel, W. E., Müller-Tidow, C."The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma". International Journal of Oncology 35, no. 1 (2009): 175-179. https://doi.org/10.3892/ijo_00000326