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PUMA is a novel target of miR-221/222 in human epithelial cancers

  • Authors:
    • Chunzhi Zhang
    • Junxia Zhang
    • Anlin Zhang
    • Yingyi Wang
    • Lei Han
    • Yongping You
    • Peiyu Pu
    • Chunsheng Kang

  • View Affiliations

  • Published online on: December 1, 2010     https://doi.org/10.3892/ijo_00000816
  • Pages: 1621-1626
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Abstract

miR-221 and miR-222 (miR-221/222) are frequently up-regulated in human epithelial cancers. However, the mechanism of miR-221/222 action involved in carcinogenesis has not been extensively studied. Here, we found that reduction of miR-221/222 inhibited cell proliferation and induced mitochondrial-mediated apoptosis in human epithelial cancer cells (A549 lung cancer and MCF-7 breast cancer cells). Bioinformatics and luciferase reporter assays showed that miR-221/222 co-modulated the p53 upregulated modulator of apoptosis (PUMA) expression by directly targeting the binding site within the 3'UTR. Together, these findings suggest that PUMA is a direct target of miR-221/222 that functions as an endogenous apoptosis regulator in these epithelial cancers.

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Journal Cover

December 2010
Volume 37 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
  • Ranked Oncology
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Zhang C, Zhang J, Zhang A, Wang Y, Han L, You Y, Pu P and Kang C: PUMA is a novel target of miR-221/222 in human epithelial cancers. Int J Oncol 37: 1621-1626, 2010.
APA
Zhang, C., Zhang, J., Zhang, A., Wang, Y., Han, L., You, Y. ... Kang, C. (2010). PUMA is a novel target of miR-221/222 in human epithelial cancers. International Journal of Oncology, 37, 1621-1626. https://doi.org/10.3892/ijo_00000816
MLA
Zhang, C., Zhang, J., Zhang, A., Wang, Y., Han, L., You, Y., Pu, P., Kang, C."PUMA is a novel target of miR-221/222 in human epithelial cancers". International Journal of Oncology 37.6 (2010): 1621-1626.
Chicago
Zhang, C., Zhang, J., Zhang, A., Wang, Y., Han, L., You, Y., Pu, P., Kang, C."PUMA is a novel target of miR-221/222 in human epithelial cancers". International Journal of Oncology 37, no. 6 (2010): 1621-1626. https://doi.org/10.3892/ijo_00000816