Second malignancies after breast cancer: The impact of adjuvant therapy (Review)

  • Authors:
    • Chunhui Dong
    • Ling Chen
  • View Affiliations

  • Published online on: February 3, 2014     https://doi.org/10.3892/mco.2014.250
  • Pages: 331-336
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Abstract

Second malignant neoplasms (SMNs) are potentially life‑threatening late sequelae of the adjuvant therapy for breast cancer (BC). The increased risk of SMNs is associated with adjuvant chemotherapy (development of secondary acute myeloid leukemia and myelodysplastic syndrome) and hormonal therapy (risk of uterine cancer secondary to tamoxifen treatment). Previous studies have demonstrated an increased risk of SMNs associated with alkylating agents, topoisomerase‑II inhibitors, granulocyte‑stimulating factors and estrogen receptor modulators. Furthermore, analytical investigations have demonstrated that BC patients may be at an increased risk of leukemia following chemotherapy. In addition, correlations between an increased dose of hormonal therapy and solid tumor risk have been identified. Considering the ongoing alterations in the treatment of BC, with respect to lowering the daily as well as the cumulative dose of chemotherapeutic agents, it is anticipated that leukemias will have a considerably lower impact on BC survivors in the future. However, diligent follow‑up is required to accurately evaluate the long‑term risks associated with chemotherapy.
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Spandidos Publications style
Dong C and Chen L: Second malignancies after breast cancer: The impact of adjuvant therapy (Review). Mol Clin Oncol 2: 331-336, 2014.
APA
Dong, C., & Chen, L. (2014). Second malignancies after breast cancer: The impact of adjuvant therapy (Review). Molecular and Clinical Oncology, 2, 331-336. https://doi.org/10.3892/mco.2014.250
MLA
Dong, C., Chen, L."Second malignancies after breast cancer: The impact of adjuvant therapy (Review)". Molecular and Clinical Oncology 2.3 (2014): 331-336.
Chicago
Dong, C., Chen, L."Second malignancies after breast cancer: The impact of adjuvant therapy (Review)". Molecular and Clinical Oncology 2, no. 3 (2014): 331-336. https://doi.org/10.3892/mco.2014.250