Prevalence of serrated polyposis syndrome and its association with synchronous advanced adenoma and lifestyle

Toyoshima,Naoya; Sakamoto,Taku; Makazu,Makomo; Nakajima,Takeshi; Matsuda,Takahisa; Kushima,Ryoji; Shimoda,Tadakazu; Fujii,Takahiro; Inoue,Haruhiro; Kudo,Shin‑Ei; Saito,Yutaka

doi:10.3892/mco.2014.423

Prevalence of serrated polyposis syndrome and its association with synchronous advanced adenoma and lifestyle

Authors:
- Naoya Toyoshima
- Taku Sakamoto
- Makomo Makazu
- Takeshi Nakajima
- Takahisa Matsuda
- Ryoji Kushima
- Tadakazu Shimoda
- Takahiro Fujii
- Haruhiro Inoue
- Shin‑Ei Kudo
- Yutaka Saito
View Affiliations

Affiliations: Endoscopy Division, National Cancer Center Hospital, Tokyo 104‑0045, Japan, Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104‑0045, Japan, Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104‑0061, Japan, TF Clinic, Tokyo 104‑0061, Japan, Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 224‑8503, Japan
Published online on: September 22, 2014 https://doi.org/10.3892/mco.2014.423
Pages: 69-72

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

We assessed the clinicopathological characteristics of patients with serrated polyposis syndrome (SPS) and the incidence of advanced adenoma/colorectal cancer (CRC). We prospectively enrolled 249 consecutive patients who underwent colonoscopy at the National Cancer Center Hospital over a 6‑month period. All the polyps were diagnosed using magnification colonoscopy and resection/biopsy. The enrolled patients were divided into two groups, i) those with ≥5 histologically diagnosed hyperplastic polyps (HPs) proximal to the sigmoid colon, with at least 2 polyps >10 mm in diameter and ii) those with ≥20 HPs distributed throughout the colon. The clinical characteristics of the two groups were compared, including lifestyle, family history of CRC and colonoscopic findings. HPs were identified in 228 patients, of whom 21 (8.4%) had SPS. All 21 patients had ≥20 HPs distributed throughout the colon, with none having >2 HPs ≥1 cm in diameter in the right colon. Synchronous advanced adenoma/CRC was diagnosed in 76̸249 (30.5%) patients. The prevalence of advanced adenoma/CRC was higher among patients with compared to those without SPS (P=0.075). SPS was also associated with older age and higher body mass index (BMI). Our results suggested that older age and higher BMI are independent risk factors for SPS. Advanced adenoma/CRC tended to occur more frequently among patients with compared to those without SPS, although the difference was not statistically significant.

View Figures

View References

1	Goldman H, Ming S and Hickock DF: Nature and significance of hyperplastic polyps of the human colon. Arch Pathol. 89:349–354. 1970.PubMed/NCBI
2	Young J, Jenkins M, Parry S, et al: Serrated pathway colorectal cancer in the population: genetic consideration. Gut. 56:1453–1459. 2007. View Article : Google Scholar : PubMed/NCBI
3	Sandmeier D, Benhattar J, Martin P and Bouzourene H: Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps. Histopathology. 55:206–213. 2009. View Article : Google Scholar : PubMed/NCBI
4	Noffsinger AE: Serrated polyps and colorectal cancer: new pathway to malignancy. Annu Rev Pathol. 4:343–364. 2009. View Article : Google Scholar : PubMed/NCBI
5	Burt RW and Jass J: Hyperplasti. polyposis. World Health Organization Classification of Tumours. Pathology and GeneticsTumours of the Digestive System. HamiltonSRAaltonenLA: Springer-Verlag; Berlin: pp. 135–136. 2000
6	Chow E, Lipton L, Lynch E, et al: Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH. Gastroenterology. 131:30–39. 2006. View Article : Google Scholar : PubMed/NCBI
7	Warner AS, Glick ME and Fogt F: Multiple large hyperplastic polyps of the colon coincident with adenocarcinoma. Am J Gastroenterol. 89:123–125. 1994.PubMed/NCBI
8	Tonooka T, Sano Y, Fujii T, et al: Adenocarcinoma in solitary large hyperplastic polyp diagnosed by magnifying colonoscope: report of a case. Dis Colon Rectum. 45:1407–1411. 2002. View Article : Google Scholar : PubMed/NCBI
9	Yano T, Sano Y, Iwasaki J, et al: Distribution and prevalence of colorectal hyperplastic polyps using magnifying pan-mucosal chromoendoscopy and its relationship with synchronous colorectal cancer: prospective study. J Gastroenterol Hepatol. 20:1572–1577. 2005. View Article : Google Scholar
10	Jorgensen H, Mogensen AM and Svendsen LB: Hyperplastic polyposis of the large bowel. Three cases and a review of the literature. Scand J Gastroenterol. 31:825–830. 1996. View Article : Google Scholar : PubMed/NCBI
11	Hyman NH, Anderson P and Blasyk H: Hyperplastic polyposis and the risk of colorectal cancer. Dis Colon Rectum. 47:2101–2104. 2004. View Article : Google Scholar : PubMed/NCBI
12	Young JP and Parry S: Risk factors: Hyperplastic polyposis syndrome and risk of colorectal cancer. Nat Rev Gastroenterol Hepatol. 7:594–595. 2010. View Article : Google Scholar : PubMed/NCBI
13	Kalady MF, Jarrar A, Leach B, et al: Defining phenotypes and cancer risk in hyperplastic polyposis syndrome. Dis Colon Rectum. 54:164–170. 2011. View Article : Google Scholar : PubMed/NCBI
14	Rashid A, Houlihan PS, Booker S, Petersen GM, Giardiello FM and Hamilton SR: Phenotypic and molecular characteristics of hyperplastic polyposis. Gastroenterology. 119:323–332. 2000. View Article : Google Scholar : PubMed/NCBI
15	Leggett BA, Devereaux B, Biden K, Searle J, Young J and Jass J: Hyperplastic polyposis: association with colorectal cancer. Am J Surg Pathol. 25:177–184. 2001. View Article : Google Scholar : PubMed/NCBI
16	Rubio CA, Stemme S, Jaramillo E and Lindblom A: Hyperplastic polyposis coli syndrome and colorectal carcinoma. Endoscopy. 38:266–270. 2006. View Article : Google Scholar : PubMed/NCBI
17	Wallace K, Grau MV, Ahnen D, et al: The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum. Cancer Epidemiol Biomarkers Prev. 18:2310–2317. 2009. View Article : Google Scholar : PubMed/NCBI
18	Kudo S, Tamura S, Nakajima T, Yamano H, Kusaka H and Watanabe H: Diagnosis of colorectal tumorous lesions by magnifying endoscopy. Gastrointest Endosc. 44:8–14. 1996. View Article : Google Scholar : PubMed/NCBI
19	Kahi CJ, Anderson JC, Waxman I, et al: High-definition chromocolonoscopy vs. high-definition white light colonoscopy for average-risk colorectal cancer screening. Am J Gastroenterol. 105:1301–1307. 2010. View Article : Google Scholar : PubMed/NCBI
20	Brooker JC, Saunders BP, Shah SG, et al: Total colonic dye-spray increases the detection of diminutive adenomas during routine colonoscopy: a randomized controlled trial. Gastrointest Endosc. 56:333–338. 2002. View Article : Google Scholar : PubMed/NCBI
21	Hurlstone DP, Cross SS, Slater R, Sanders DS and Brown S: Detecting diminutive colorectal lesions at colonoscopy: a randomised controlled trial of pan-colonic versus targeted chromoscopy. Gut. 53:376–380. 2004. View Article : Google Scholar : PubMed/NCBI
22	Lapalus MG, Helbert T, Napoleon B, et al: Does chromoendoscopy with structure enhancement improve the colonoscopic adenoma detection rate? Endoscopy. 38:444–448. 2006. View Article : Google Scholar : PubMed/NCBI
23	Le Rhun M, Coron E, Parlier D, et al: High resolution colonoscopy with chromoscopy versus standard colonoscopy for the detection of colonic neoplasia: a randomized study. Clin Gastroenterol Hepatol. 4:349–354. 2006.PubMed/NCBI
24	Walker RG, Landmann JK, Hewett DG, et al: Hyperplastic polyposis syndrome is associated with cigarette smoking, which may be a modifiable risk factor. Am J Gastroenterol. 105:1642–1647. 2010. View Article : Google Scholar : PubMed/NCBI
25	Otani T, Iwasaki M, Yamamoto S, et al Japan Public Health Center-based Prospective Study Group: Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study. Cancer Epidemiol Biomarkers Prev. 12:1492–1500. 2003.
26	Jeevaratnam P, Cottier DS, Browett PJ, Van De Water NS, Pokos V and Jass JR: Familial giant hyperplastic polyposis predisposing to colorectal cancer: a new hereditary bowel cancer syndrome. J Pathol. 179:20–25. 1996. View Article : Google Scholar : PubMed/NCBI