Characteristics and prognosis of mucinous gastric carcinoma
- Authors:
- Taro Isobe
- Kousuke Hashimoto
- Junya Kizaki
- Satoru Matono
- Naotaka Murakami
- Tetsushi Kinugasa
- Keishiro Aoyagi
- Yoshito Akagi
View Affiliations
Affiliations: Department of Surgery, Kurume University School of Medicine, Fukuoka 830-0011, Japan
- Published online on: October 22, 2014 https://doi.org/10.3892/mco.2014.447
-
Pages:
44-50
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
Mucinous gastric carcinoma (MGC) is a rare histological subtype of undifferentiated gastric carcinoma, accounting for ~2.6-6.6% of all gastric cancer cases. The clinicopathological characteristics and prognosis of MGC are controversial. The present study aimed to determine the clinicopathological characteristics and prognosis of patients with MGC. We retrospectively compared the characteristics and postoperative survival of 70 patients with MGC and 2,492 non-MGC (NMGC) cases who underwent surgical resection between 1990 and 2010. MGC was characterised by larger tumor size, macroscopic Borrmann type 2 and 3, T4 invasion of the gastric wall, positive N2 and N3 lymph node metastasis, positive lymphatic vessel invasion, positive venous invasion, peritoneal metastasis and advanced tumor stage III and IV. The prognosis of MGC patients was worse compared to that of NMGC patients, as the former group consisted of more advanced‑stage cases. When patients with similar disease stages were compared, the incidence of peritoneal metastasis was significantly higher among MGC patients. However, hepatic metastasis was found significantly more often in NMGC patients. Otherwise, the prognosis of MGC and NMGC patients with similar disease stages was not significantly different. Therefore, our findings indicated that, although MGC is more rare and mostly detected at an advanced stage, the diagnosis of the mucinous histological subtype was not an independent prognostic factor.
View References
|
1
|
Parkin DM, Bray FI and Devesa SS: Cancer
burden in the year 2000. The global picture. Eur J Cancer. 37
(Suppl 8):4–66. 2001.PubMed/NCBI
|
|
2
|
Santoro R, Carboni F, Lepiane P, Ettorre
GM and Santoro E: Clinicopathological features and prognosis of
gastric cancer in young European adults. Br J Surg. 94:737–742.
2007. View
Article : Google Scholar : PubMed/NCBI
|
|
3
|
Lee HH, Song KY, Park CH and Jeon HM:
Undifferentiated-type gastric adenocarcinoma: prognostic impact of
three histological types. World J Surg Oncol.
10(254)2012.PubMed/NCBI
|
|
4
|
Kunisaki C, Akiyama H, Nomura M, Matsuda
G, Otsuka Y, Ono HA and Shimada H: Clinicopathologic
characteristics and surgical outcomes of mucinous gastric
carcinoma. Ann Surg Oncol. 13:836–842. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kawamura H, Kondo Y, Osawa S, et al: A
clinicopathologic study of mucinous adenocarcinoma of the stomach.
Gastric Cancer. 4:83–86. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Zhang M, Zhu GY, Zhang HF, Gao HY, Han XF
and Xue YW: Clinicopathologic characteristics and prognosis of
mucinous gastric carcinoma. J Surg Oncol. 102:64–67. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Adachi Y, Mori M, Kido A, Shimono R,
Maehara Y and Sugimachi K: A clinicopathologic study of mucinous
gastric carcinoma. Cancer. 69:866–871. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Hyung WJ, Noh SH, Shin DW, Yoo CH, Kim CB,
Min JS and Lee KS: Clinicopathologic characteristics of mucinous
gastric adenocarcinoma. Yonsei Med J. 40:99–106. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Lim SW, Kim DY, Kim YJ and Kim SK:
Clinicopathologic features of mucinous gastric carcinoma. Dig Surg.
19:286–290. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Wu CY, Yeh HZ, Shih RT and Chen GH: A
clinicopathologic study of mucinous gastric carcinoma including
multivariate analysis. Cancer. 83:1312–1318. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Yasuda K, Shiraishi N, Inomata M,
Shiroshita H, Ishikawa K and Kitano S: Clinicopathologic
characteristics of early-stage mucinous gastric carcinoma. J Clin
Gastroenterol. 38:507–511. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Watanabe H, Jass JR and Sobin LH:
Histological typing of oesophageal and gastric tumors: WHO
international histological classification of tumors. (2nd). Cancer.
66:2162–2167. 1990.
|
|
13
|
Japanese Gastric Cancer Association, .
Japanese classification of gastric carcinoma: 3rd English edition.
Gastric Cancer. 14:101–112. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Yin C, Li D, Sun Z, Zhang T, Xu Y, Wang Z
and Xu H: Clinicopathologic features and prognosis analysis of
mucinous gastric carcinoma. Med Oncol. 29:864–870. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Sadahiro S, Ohmura T, Saito T and Akatsuka
S: An assessment of the mucous component in carcinoma of the colon
and rectum. Cancer. 64:1113–1116. 1989. View Article : Google Scholar : PubMed/NCBI
|
