Accurate diagnosis of axillary lymph node metastasis using contrast-enhanced ultrasonography with Sonazoid

Matsuzawa,Fumihiko; Einama,Takahiro; Abe,Hironori; Suzuki,Takashi; Hamaguchi,Jun; Kaga,Terumi; Sato,Mami; Oomura,Masako; Takata,Yumiko; Fujibe,Ayako; Takeda,Chie; Tamura,Etsuya; Taketomi,Akinobu; Kyuno,Kenichi

doi:10.3892/mco.2014.483

Accurate diagnosis of axillary lymph node metastasis using contrast-enhanced ultrasonography with Sonazoid

Authors:
- Fumihiko Matsuzawa
- Takahiro Einama
- Hironori Abe
- Takashi Suzuki
- Jun Hamaguchi
- Terumi Kaga
- Mami Sato
- Masako Oomura
- Yumiko Takata
- Ayako Fujibe
- Chie Takeda
- Etsuya Tamura
- Akinobu Taketomi
- Kenichi Kyuno
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Affiliations: Department of Surgery, Hokkaido Social Work Association Obihiro Hospital, Obihiro, Hokkaido 080‑0805, Japan, Department of Clinical Laboratory, Hokkaido Social Work Association Obihiro Hospital, Obihiro, Hokkaido 080‑0805, Japan, Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan
Published online on: December 31, 2014 https://doi.org/10.3892/mco.2014.483
Pages: 299-302

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Abstract

Axillary lymph node enlargement following sentinel lymph node biopsy (SLNB) is often difficult to accurately diagnose. In keeping with the characteristically tortuous and aberrant pattern of tumor neovasculature, metastatic lymph nodes exhibit peripheral and mixed vascularity, resulting in a microvasculature that is often difficult to visualize. Contrast‑enhanced ultrasonography (CEUS) with Sonazoid, a new generation contrast agent for ultrasonography, allows for the visualization of lymph node microvessels and may enable a more accurate evaluation of lymph node metastasis. This is a case report of axillary lymph node enlargement following SLNB, in which CEUS with Sonazoid resulted in an accurate diagnosis. On the basis of our experience with this case, we have initiated a clinical trial to evaluate the detection of lymph node metastasis through the use of CEUS in breast cancer patients.

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1	Lyman GH, Giuliano AE, Somerfield MR, et al American Society of Clinical Oncology: American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol. 23:7703–7720. 2005. View Article : Google Scholar : PubMed/NCBI
2	McCready D, Holloway C, Shelley W, et al: Breast Cancer Disease Site Group of Cancer Care; Ontario's Program in Evidence-Based Care: Surgical management of early stage invasive breast cancer: a practice guideline. Can J Surg. 48:185–194. 2005.PubMed/NCBI
3	Dabakuyo TS, Fraisse J, Causeret S, et al: A multicenter cohort study to compare quality of life in breast cancer patients according to sentinel lymph node biopsy or axillary lymph node dissection. Ann Oncol. 20:1352–1361. 2009. View Article : Google Scholar : PubMed/NCBI
4	Naik AM, Fey J, Gemignani M, et al: The risk of axillary relapse after sentinel lymph node biopsy for breast cancer is comparable with that of axillary lymph node dissection: a follow-up study of 4008 procedures. Ann Surg. 240:462–471. 2004. View Article : Google Scholar : PubMed/NCBI
5	Yang WT, Chang J and Metreweli C: Patients with breast cancer: differences in color Doppler flow and gray-scale US features of benign and malignant axillary lymph nodes. Radiology. 215:568–573. 2000. View Article : Google Scholar : PubMed/NCBI
6	Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI
7	Fisher B, Anderson S, Bryant J, et al: Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 347:1233–1241. 2002. View Article : Google Scholar : PubMed/NCBI
8	Jacobson JA, Danforth DN, Cowan KH, et al: Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med. 332:907–911. 1995. View Article : Google Scholar : PubMed/NCBI
9	Lacour J, Le M, Caceres E, Koszarowski T, Veronesi U and Hill C: Radical mastectomy versus radical mastectomy plus internal mammary dissection. Ten year results of an international cooperative trial in breast cancer. Cancer. 51:1941–1943. 1983. View Article : Google Scholar : PubMed/NCBI
10	Maddox WA, Carpenter JT, Laws HL, et al: A randomized prospective trial of radical (Halsted) mastectomy versus modified radical mastectomy in 311 breast cancer patients. Ann Surg. 198:207–212. 1983. View Article : Google Scholar : PubMed/NCBI
11	Turner L, Swindell R, Bell WG, et al: Radical versus modified radical mastectomy for breast cancer. Ann R Coll Surg Engl. 63:239–243. 1981.PubMed/NCBI
12	Cabanas RM: An approach for the treatment of penile carcinoma. Cancer. 39:456–466. 1977. View Article : Google Scholar : PubMed/NCBI
13	Kim T, Giuliano AE and Lyman GH: Lymphatic mapping and sentinel lymph node biopsy in early-stage breast carcinoma: a meta-analysis. Cancer. 106:4–16. 2006. View Article : Google Scholar : PubMed/NCBI
14	Houssami N, Ciatto S, Turner RM, Cody HS and Macaskill P: Preoperative ultrasound-guided needle biopsy of axillary nodes in invasive breast cancer: meta-analysis of its accuracy and utility in staging the axilla. Ann Surg. 254:243–251. 2011. View Article : Google Scholar : PubMed/NCBI
15	Ko EY, Han BK, Shin JH and Kang SS: Breast MRI for evaluating patients with metastatic axillary lymph node and initially negative mammography and sonography. Korean J Radiol. 8:382–389. 2007. View Article : Google Scholar : PubMed/NCBI
16	Mameri CS, Kemp C, Goldman SM, Sobral LA and Ajzen S: Impact of breast MRI on surgical treatment, axillary approach, and systemic therapy for breast cancer. Breast J. 14:236–244. 2008. View Article : Google Scholar : PubMed/NCBI
17	Garcia Fernández A, Fraile M, Giménez N, et al: Use of axillary ultrasound, ultrasound-fine needle aspiration biopsy and magnetic resonance imaging in the preoperative triage of breast cancer patients considered for sentinel node biopsy. Ultrasound Med Biol. 37:16–22. 2011. View Article : Google Scholar : PubMed/NCBI
18	Harnan SE, Cooper KL, Meng Y, et al: Magnetic resonance for assessment of axillary lymph node status in early breast cancer: a systematic review and meta-analysis. Eur J Surg Oncol. 37:928–936. 2011. View Article : Google Scholar : PubMed/NCBI
19	Kvistad KA, Rydland J, Smethurst HB, Lundgren S, Fjosne HE and Haraldseth O: Axillary lymph node metastases in breast cancer: preoperative detection with dynamic contrast-enhanced MRI. Eur Radiol. 10:1464–1471. 2000. View Article : Google Scholar : PubMed/NCBI
20	Peare R, Staff RT and Heys SD: The use of FDG-PET in assessing axillary lymph node status in breast cancer: a systematic review and meta-analysis of the literature. Breast Cancer Res Treat. 123:281–290. 2010. View Article : Google Scholar : PubMed/NCBI
21	Valente SA, Levine GM, Silverstein MJ, et al: Accuracy of predicting axillary lymph node positivity by physical examination, mammography, ultrasonography, and magnetic resonance imaging. Ann Surg Oncol. 19:1825–1830. 2012. View Article : Google Scholar : PubMed/NCBI
22	Hwang SO, Lee SW, Kim HJ, Kim WW, Park HY and Jung JH: The comparative study of ultrasonography, contrast-enhanced MRI, and18F-FDG PET/CT for detecting axillary lymph node metastasis in T1 breast cancer. J Breast Cancer. 16:315–321. 2013. View Article : Google Scholar : PubMed/NCBI
23	Quon A and Gambhir SS: FDG-PET and beyond: molecular breast cancer imaging. J Clin Oncol. 23:1664–1673. 2005. View Article : Google Scholar : PubMed/NCBI
24	Omoto K, Matsunaga H, Take N, et al: Sentinel node detection method using contrast-enhanced ultrasonography with Sonazoid in breast cancer: preliminary clinical study. Ultrasound Med Biol. 35:1249–1256. 2009. View Article : Google Scholar : PubMed/NCBI
25	Aoki T, Moriyasu F, Yamamoto K, Shimizu M, Yamada M and Imai Y: Image of tumor metastasis and inflammatory lymph node enlargement by contrast-enhanced ultrasonography. World J Radiol. 3:298–305. 2011. View Article : Google Scholar : PubMed/NCBI