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Rapid and early α‑fetoprotein and des‑γ‑carboxy prothrombin responses to initial arterial infusion chemotherapy predict treatment outcomes of advanced hepatocellular carcinoma

  • Authors:
    • Kenji Oyama
    • Masahiko Koda
    • Takaaki Sugihara
    • Manabu Kishina
    • Kenichi Miyoshi
    • Toshiaki Okamoto
    • Masanori Hodotsuka
    • Yuki Fujise
    • Tomomitsu Matono
    • Shiho Tokunaga
    • Kinya Okamoto
    • Keiko Hosho
    • Junichi Okano
    • Yoshikazu Murawaki

  • View Affiliations

  • Published online on: March 3, 2015     https://doi.org/10.3892/mco.2015.523
  • Pages: 655-662
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Abstract

The aim of the present study was to predict the effects of transarterial infusion (TAI) chemotherapy based on early changes in α‑fetoprotein (AFP) and des‑γ‑carboxy prothrombin (DCP) in patients with advanced hepatocellular carcinoma (HCC). Seventy‑four patients who underwent TAI with cisplatin, 5‑fluorouracil, mitomycin C and epirubicin for advanced HCC were enrolled. Antitumor responses were evaluated 6 months after TAI. Rapid and early responses were defined as the ratio of AFP or DCP after 1 week and 1 month compared to baseline. A total of 5, 10, 17 and 42 patients had complete response (CR), partial response (PR), stable disease (SD) or progressive disease (PD), respectively. Early AFP response was significantly lower in the CR+PR compared to the SD+PD groups (P<0.01). The early DCP response was significantly lower in the CR+PR compared to the SD+PD. The sensitivity and specificity of rapid and early AFP responses in the CR+PR were 0.78 and 0.72, and 0.80 and 0.73, respectively, and those of rapid and early DCP responses were 0.67 and 0.65, and 0.77 and 0.71, respectively. The combination of AFP and DCP responses had higher specificity compared to AFP or DCP alone responses. Patients were divided into responder and non‑responder groups to evaluate the prediction of survival outcome. Early responders of AFP, DCP and AFP+DCP, who were divided based on the cut-off values of CR+PR survived significantly longer than the non‑responders (P<0.05). In conclusion, rapid or early responses of AFP and/or DCP levels 1 and 4 weeks after TAI chemotherapy helped to predict the treatment effects.
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May-2015
Volume 3 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Oyama K, Koda M, Sugihara T, Kishina M, Miyoshi K, Okamoto T, Hodotsuka M, Fujise Y, Matono T, Tokunaga S, Tokunaga S, et al: Rapid and early α‑fetoprotein and des‑γ‑carboxy prothrombin responses to initial arterial infusion chemotherapy predict treatment outcomes of advanced hepatocellular carcinoma. Mol Clin Oncol 3: 655-662, 2015.
APA
Oyama, K., Koda, M., Sugihara, T., Kishina, M., Miyoshi, K., Okamoto, T. ... Murawaki, Y. (2015). Rapid and early α‑fetoprotein and des‑γ‑carboxy prothrombin responses to initial arterial infusion chemotherapy predict treatment outcomes of advanced hepatocellular carcinoma. Molecular and Clinical Oncology, 3, 655-662. https://doi.org/10.3892/mco.2015.523
MLA
Oyama, K., Koda, M., Sugihara, T., Kishina, M., Miyoshi, K., Okamoto, T., Hodotsuka, M., Fujise, Y., Matono, T., Tokunaga, S., Okamoto, K., Hosho, K., Okano, J., Murawaki, Y."Rapid and early α‑fetoprotein and des‑γ‑carboxy prothrombin responses to initial arterial infusion chemotherapy predict treatment outcomes of advanced hepatocellular carcinoma". Molecular and Clinical Oncology 3.3 (2015): 655-662.
Chicago
Oyama, K., Koda, M., Sugihara, T., Kishina, M., Miyoshi, K., Okamoto, T., Hodotsuka, M., Fujise, Y., Matono, T., Tokunaga, S., Okamoto, K., Hosho, K., Okano, J., Murawaki, Y."Rapid and early α‑fetoprotein and des‑γ‑carboxy prothrombin responses to initial arterial infusion chemotherapy predict treatment outcomes of advanced hepatocellular carcinoma". Molecular and Clinical Oncology 3, no. 3 (2015): 655-662. https://doi.org/10.3892/mco.2015.523