Implication of duration of clinical presentation on tumor progression and short‑term recurrence in patients with early breast cancer

Fujii,Takaaki; Yajima,Reina; Morita,Hiroki; Suto,Toshinaga; Tatsuki,Hironori; Tsutsumi,Soichi; Kuwano,Hiroyuki

doi:10.3892/mco.2015.538

July-2015 Volume 3 Issue 4

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July-2015 Volume 3 Issue 4

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Article

Implication of duration of clinical presentation on tumor progression and short‑term recurrence in patients with early breast cancer

Authors:
- Takaaki Fujii
- Reina Yajima
- Hiroki Morita
- Toshinaga Suto
- Hironori Tatsuki
- Soichi Tsutsumi
- Hiroyuki Kuwano
View Affiliations / Copyright

Affiliations: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371‑8511, Japan
Pages: 785-788
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Published online on: April 3, 2015

https://doi.org/10.3892/mco.2015.538
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Abstract

Breast cancer growth is dependent on time and it may be of utmost importance to take into consideration the duration of clinical symptoms in order to predict which patients are at high risk for disease recurrence. The aim of this study was to determine the association between duration of clinical symptoms and disease recurrence in patients with breast cancer. A total of 139 consecutive patients with primary breast cancer who underwent a radical breast operation were retrospectively investigated and the association between recurrence and the duration of symptoms was investigated. The duration of clinical signs was defined as the time from the onset of symptoms to the date of surgery. The breast cancer cases were divided into two groups on the basis of symptom duration (≤6 and >6 months). The mean duration of symptoms was 191.0±242.6 days. Of the 139 cases, 36 (25.9%) had a duration of symptoms of >6 months. In the univariate analysis, a statistically significant association with long symptom duration was observed for disease recurrence. Of the 139 patients, 6 (4.3%) developed recurrent disease. The univariate analysis revealed that long duration of symptoms and nuclear grade were significantly associated with recurrence. In conclusion, our results indicated that breast cancer progression is dependent on time. A long duration of symptoms (>6 months) may be considered as an indicator of tumor progression and a strong prognostic factor in breast cancer patients.

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1	Woodward WA, Strom EA, Tucker SL, et al: Changes in the 2003 American Joint Committee on Cancer staging for breast cancer dramatically affect stage-specific survival. J Clin Oncol. 21:3244–3248. 2003. View Article : Google Scholar : PubMed/NCBI
2	Taghian A, Jeong JH, Mamounas E, Anderson S, Bryant J, Deutsch M and Wolmark N: Patterns of locoregional failure in patients with operable breast cancer treated by mastectomy and adjuvant chemotherapy with or without tamoxifen and without radiotherapy: Results from five National Surgical Adjuvant Breast and Bowel Project randomized clinical trials. J Clin Oncol. 22:4247–4254. 2004. View Article : Google Scholar : PubMed/NCBI
3	Fujii T, Yanagita Y, Fujisawa T, Hirakata T, Iijima M and Kuwano H: Implication of extracapsular invasion of sentinel lymph nodes in breast cancer: Prediction of nonsentinel lymph node metastasis. World J Surg. 34:544–548. 2010. View Article : Google Scholar : PubMed/NCBI
4	Barginear MF, Bradley T, Shapira I and Budman DR: Implications of applied research for prognosis and therapy of breast cancer. Crit Rev Oncol Hematol. 65:223–234. 2008. View Article : Google Scholar : PubMed/NCBI
5	Richards MA, Smith P, Ramirez AJ, Fentiman IS and Rubens RD: The influence on survival of delay in the presentation and treatment of symptomatic breast cancer. Br J Cancer. 79:858–864. 1999. View Article : Google Scholar : PubMed/NCBI
6	Senkus E, Cardoso F and Pagani O: Time for more optimism in metastatic breast cancer? Cancer Treat Rev. 40:220–228. 2014. View Article : Google Scholar : PubMed/NCBI
7	Burgess CC, Ramirez AJ, Richards MA and Love SB: Who and what influences delayed presentation in breast cancer? Br J Cancer. 77:1343–1348. 1998. View Article : Google Scholar : PubMed/NCBI
8	MacArthur C and Smith A: Delay in breast cancer and the nature of presenting symptoms. Lancet. 1:601–603. 1981. View Article : Google Scholar : PubMed/NCBI
9	Allred DC, Harvey JM, Berardo M and Clark GM: Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 11:155–168. 1998.PubMed/NCBI
10	Shousha S: Oestrogen receptor status of breast carcinoma: Allred/H score conversion table. Histopathology. 53:346–347. 2008. View Article : Google Scholar : PubMed/NCBI
11	Love RR, Duc NB, Baumann LC, Anh PT, To TV, Qian Z and Havighurst TC: Duration of signs and survival in premenopausal women with breast cancer. Breast Cancer Res Treat. 86:117–124. 2004. View Article : Google Scholar : PubMed/NCBI
12	Richards MA, Westcombe AM, Love SB, Littlejohns P and Ramirez AJ: Influence of delay on survival in patients with breast cancer: A systematic review. Lancet. 353:1119–1126. 1999. View Article : Google Scholar : PubMed/NCBI
13	Ahmed M and Douek M: The management of screen-detected breast cancer. Anticancer Res. 34:1141–1146. 2014.PubMed/NCBI
14	Joensuu H, Lehtimäki T, Holli K, Elomaa L, Turpeenniemi-Hujanen T, Kataja V, Anttila A, Lundin M, Isola J and Lundin J: Risk for distant recurrence of breast cancer detected by mammography screening or other methods. JAMA. 292:1064–1073. 2004. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Implication of duration of clinical presentation on tumor progression and short‑term recurrence in patients with early breast cancer

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