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Introduction

Large randomized trials (1,2) have demonstrated certain clinical benefits of preoperative therapy for gastric cancer. Subsequently, the role of preoperative chemotherapy has been established in locally advanced gastric cancer patients. However, such patients complicated with gastric outlet obstruction (GOO) are generally not treated as appropriate candidates for preoperative chemotherapy in the current clinical practice due to patients' intolerance to chemotherapeutic medications. Whether there is a role of chemotherapy as a preoperative treatment for advanced gastric cancer with GOO is unknown.

Whether GOO had been considered as eligibility or ineligibility criterion of protocols was not disclosed in previously published literature regarding clinical trials, even in the MAGIC (1) and FNCLCC ACCORD 07-FFCD 9703 (2) studies that are landmarks in this field. Thus, there is no available data regarding feasibility, safety or efficacy of preoperative chemotherapy for the subgroup of gastric cancer patients with GOO revealed in these studies. Additionally, GOO is occasionally treated as an exclusive criterion in the protocol of certain clinical trials concerning preoperative chemotherapy for gastric cancer (3). Therefore, the universality of clinical benefit induced by preoperative chemotherapy has some limitations due to the lack of data in the GOO subset, which is an elementary subgroup of gastric cancer.

Whether there is a potential role of preoperative chemotherapy in the treatment of gastric cancer patients with GOO requires investigation. In order to answer this novel question, a literature review was conducted and a prospective outlook was made in this field.

Materials and methods

Search strategies

A systematic electronic literature search was conducted in the PubMed database, Embase and Cochrane Library (until January 2015). All publications associated with preoperative chemotherapy for gastric cancer patients with GOO were targets of the retrieval. Clinical trials registered in NIH (ClinicalTrials.gov) were also retrieved. No restrictions on language were applied to the retrieval strategies. Retrieval with a multistage process was carried out as follows.

Step 1. In the PubMed database, the search was conducted using terms of medical subject headings (MeSH) that were ‘stomach neoplasms’, (‘gastric outlet obstruction’ or ‘pyloric stenosis’) and ‘neoadjuvant therapy’, which was firstly applied.

Step 2. Due to the extreme scarcity of the retrieved results, an additional extensive search using free terms was further conducted.

The equivalent free terms of ‘stomach neoplasms’ are ‘gastric cancer’, ‘gastric carcinoma’, ‘gastric adenocarcinoma’, ‘stomach cancer’, ‘stomach carcinoma’, ‘stomach adenocarcinoma’, ‘cancer of the stomach’, ‘carcinoma of the stomach’, ‘adenocarcinoma of the stomach’, ‘gastric neoplasm’, ‘gastric neoplasms’, ‘neoplasm of the stomach’ and ‘neoplasms of the stomach’.

The equivalent free terms of ‘gastric outlet obstruction’ and ‘pyloric stenosis’ are ‘pyloric obstruction’, ‘pyloric stenosis’, ‘antrum obstruction’, ‘antrum stenosis’, ‘gastric obstruction’, ‘gastric stenosis’, ‘outlet obstruction’, ‘outlet stenosis’, ‘obstruction of the stomach’, ‘obstruction of the pylorus’, ‘obstruction of the antrum’ and ‘stenosis of the pylorus’.

The equivalent free terms of ‘neoadjuvant therapy’ are ‘neoadjuvant chemotherapy’, ‘neoadjuvant treatment’, ‘preoperative therapy’, ‘preoperative chemotherapy’, ‘preoperative treatment’, ‘perioperative therapy’, ‘perioperative chemotherapy’, ‘perioperative treatment’ and ‘induction chemotherapy’.

Step 3. The MeSH search (step 1) was extended by substituting ‘drug therapy’ for ‘neoadjuvant therapy’.

Step 4. Similar retrieval strategies, as mentioned above, were also conducted in Embase and Cochrane Library.

Step 5. Retrieval in ClinicalTrials.gov was performed in ‘expert search’ using the free terms mentioned above.

Data extraction

All the studies obtained were read in full. Characteristics of the retrieved studies were summarized, and the essential information of each eligible study was extracted, such as author names, year of publication, country of investigators, sample size, chemotherapy regimen, cycles of preoperative chemotherapy, clinical outcomes and adverse events. Two reviewers independently extracted the data from each study. No statistical analysis was employed on account of limited quantity and quality of these publications.

Results

Application of MeSH terms

The search using the MeSH terms in step 1 located only 2 studies, of which 1 was in accordance with the retrieval purpose (4). A further search using free and MeSH terms located 20 studies, of which 11 met the retrieval purpose (4–14) (Step 2). Among these, 2 were clinical research studies (4,5), while the other 9 were case reports (6–14). No additional literature was obtained either by substituting ‘drug therapy’ for ‘neoadjuvant therapy’ (step 3) or from Embase and Cochrane Library (step 4). No relevant trial registered in ClinicalTrials.gov met the criteria (step 5). Detailed characteristics regarding the 11 studies are summarized in Table I.

Table I. Distribution characteristics of the retrieved studies.

Table I.

Distribution characteristics of the retrieved studies.

Distribution characteristics	No. of retrieved studies
Study classification
Clinical study	2
Case report	9
Nationality of the author
Eastern countries	11
China	2
Japan	9
Western countries	0
Publication journals
Chinese Journal of Cancer Research	1
Zhonghua Yi Xue Za Zhi	1
Gan to Kagaku Ryoho	9
Publication number in each decade
1990s	2
2000s	5
2010s	4
Language used in the original study
English	1
Chinese	1
Japanese	9

The 9 case reports involved 10 patients, whose age ranged from 44 to 74 years, with a male to female ratio of 6:4. All these individuals had a primary GOO caused by advanced gastric cancer and received preoperative chemotherapy with fluoropyrimidine-based regimens of 2–6 cycles. The chemicals concurrently administered with fluoropyrimidine varied from cisplatin (7 cases) (6,7,9,11,13,14) to paclitaxel (4 cases) (8,9,11,12), leucovorin (1 case) (13) and methotrexate (1 case) (14). Trastuzumab was used in 3 HER2-positive patients (6,7). Whether and how parenteral or enteral nutritional support was implemented was not disclosed in 8 (6,7,9–14) abstracts and 1 full text (8). Following preoperative chemotherapy, symptoms of GOO were relieved in 5 patients (8–10,12,13), while they remained in 2 individuals (11,14) and developed in 3 patients (6,7). Details regarding the 10 subjects are shown in Table II.

Table II. Details of the 10 patients in the 9 case reports.

Table II.

Details of the 10 patients in the 9 case reports.

First author	Gender, age (years)	Disease status	Regimen	Outcomes	(Refs.)
Du	Female, 53	T4aN2M0	S-1 + paclitaxel, 3 cycles	i) PR (the CT scan suggested a significantly reduced volume of the antral tumor, and LNs around the stomach and the pancreas were not as evident as previously). ii) Radical gastrectomy with D2+ dissection performed. iii) Subcomplete pathological remission. iv) No recurrence during the nine months of postoperative follow-up	(8)
Yasuyama	Male, 62	cT4bN3M0, unresectable, type 3, HER2 positive	S-1 + cisplatin + trastuzumab, 3 cycles	i) Significant tumor and lymph node reduction. ii) Pyloric stenosis developed. iii) Curative distal gastrectomy with D2 lymphadenectomy performed	(6)
Nakayama	Male, 57	Virchow' s LN M, HER2 positive	Capecitabine + cisplatin + trastuzumab, 2 cycles	i) Pyloric stenosis developed. ii) Distal gastrectomy performed. iii) Residual LN shrinkage induced by postoperative capecitabine + trastuzumab	(7)
	Male, 62	Peritoneal M, HER2 positive	S-1 + cisplatin + trastuzumab, 5 cycles	i) Pyloric stenosis developed. ii) Total gastrectomy performed. iii) Stable condition with postoperatively S-1 + cisplatin + trastuzumab
Yamaguchi	Male, 74	M to group 2 LNs, M1, type 3	5-FU + cisplatin + paclitaxel, 2 cycles	i) Marked reduction of the primary tumor and metastatic LNs in gastroscopy and CT. ii) Shrinkage of the primary tumor in gastrography. iii) Distal gastrectomy performed. iv) CR in primary lesion and numerous LNs and PR in 6 LNs, pathologically	(9)
Shikano	Female, 69	Peritoneal M, type 2	Not reported in abstract	i) Distal gastrectomy acquired. ii) No re-growth of peritoneal dissemination was observed for 3 years with postoperative S-1	(10)
Hokita	Female, 44	Peritoneal and navel M, type 4	S-1 + paclitaxel, 5 cycles	i) GOO relieved. ii) Total gastrectomy with D2 and transverse colectomy and splenectomy performed. iii) No recurrence during the 5 months of postoperative follow-up	(12)
Sakurai	Male, 65	Group 3 LNs and multiple liver M, type 3	5-Fu + cisplatin + paclitaxel, 3 cycles	i) Marked reduction of the primary tumor, liver M, and LNs in CT. ii) Shrinkage of the primary tumor in gastrography and gastroscopy. iii) Pylorous stenosis remained. iv) Distal gastrectomy performed. v) Grade 2 histological responses	(11)
Tanabe	Female, 73	M to para-aortic LNs, type 2, signet-ring cell carcinoma	5-FU + cisplatin + leucovorin, 2 cycles	i) The tumor size evidently shrunk and the enlargement of the para-aortic lymph nodes disappeared. ii) Distal gastrectomy with extended lymphadenectomy and cholecystectomy was performed. iii) The histological findings of the primary tumor and metastatic LNs demonstrated massive cancer cell degeneration	(13)
Iwamoto	Male, 54	Liver and peritoneal M, type 4	5-FU + cisplatin + methotrexate, 6 cycles	i) No effect was observed following the prior 2 cycles; the primary lesion decreased to 60% and the liver M to 72% subsequent to the following 6 cycles. ii) Pylorous stenosis remained. iii) Gastrojejunostomy was performed. iv) Grade 2 histological responses in LN. v) Succumbed to exacerbation of carcinomatous peritonitis 10 months after the initial admission	(14)

[i] PR, partial response; LN, lymph node; M, metastases; CR, complete response.

The 2 clinical research studies were of retrospective studies performed in the Asian population. The essential information of the 2 studies are summarized in Table III and as follows.

Table III. Details of the two retrospective studies.

Table III.

Details of the two retrospective studies.

First author	Study design	Cases, n (study duration)	Candidates	GroupingW	Regimen	Nutritional support	(Refs.)
Sun	Retrospective cohort study	116 (January 2004 until June 2013)	AGC (stage II, III and IV included) with GOO	A: NAC + NS + OP, 62 cases	Folfox, mean 2.7 (1–4) cycles		(5)
				A1: NAC + EN + OP, 32 cases	Folfox, mean 3.1 cycles	EN: Fresubin Diabetesa or Nutrison Fibreb, 2,093–6,280 kJ/day via naso-jejunal tube or PEGJ, 40–85 days
				A2: NAC + PN + OP, 30 cases	Folfox, mean 1.5 cycles	PN: 104.7–125.6 kJ/kg•day, 20–35 days
				B: OP, 54 cases
Yamaguchi	Retrospective case series study	13 (September 2001 until unknown date)	AGC (far advanced or non-curative respectable) with GOO	Single group	Paclitaxel + cisplatin + 5-FU, ≥2 cycles	Not disclosed	(4)

a Fresubin Diabetes produced by Sino-Swed Pharmaceutical Corp., Ltd.

b Nutrison Fibre, produced by Nutricia. AGC, advanced gastric cancer; GOO, gastric outlet obstruction; NAC, neoadjuvant chemotherapy; NS, nutritional support; OP, operation; EN, enteral nutritional support; PN, parenteral nutritional support; PEGJ, percutaneous endoscopic gastrojejunostomy.

A retrospective descriptive study

Yamaguchi et al (4) performed a critical evaluation of preoperative chemotherapy (‘neoadjuvant chemotherapy’ in the original text) with paclitaxel, fluorouracil and cisplatin for advanced gastric cancer patients complicated with GOO. Thirteen patients with far advanced or non-curative respectable gastric cancer with GOO received preoperative chemotherapy. These patients were treated with 40 mg/m2 paclitaxel on days 1 and 8, combined with 6.5 mg/m2 cisplatin and 350 mg/m2 fluorouracil on days 1 through 8 followed by a 2-week rest as one course. After at least two courses of treatment, the patients underwent gastrectomy with lymphadenectomy. The overall response rate (ORR) was 38.5%. Seven patients had received staging laparoscopy prior to preoperative chemotherapy and 6 had free cancer cells in the peritoneal cavity. Of the 6 subjects with positive cytology at laparoscopy, 4 had no free cancer cells at surgery following preoperative chemotherapy. The median survival time was 405 days and the 1-year survival rate was 55.6%. Toxicities were generally mild, and no serious adverse reactions were observed. There were only 2 cases that experienced grade 3 neutropenia. The authors concluded that preoperative chemotherapy with a combination of paclitaxel plus fluorouracil and cisplatin appeared to be an effective treatment for advanced gastric cancer patients with GOO. Whether and how parenteral or enteral nutritional support was implemented was not represented in the abstract. The data above were adapted from the online abstract.

A retrospective analytic study

Sun et al (5) conducted a retrospective study to explore the efficacies of preoperative chemotherapy (‘neoadjuvant chemotherapy’ in original text) plus nutritional support for advanced gastric cancer patients complicated with GOO. Retrospective analyses were performed for a total of 116 patients between January 2004 and June 2013. A total of 62 patients (group A) received preoperative chemotherapy (FOLFOX) plus concurrently administered nutritional support. Parenteral (PN, n=30) or enteral (EN, n=32) nutritional support was provided. The remaining 54 patients (group B) underwent exploratory laparotomy without preoperative chemotherapy. The serum level of albumin and quality of life score on the last preoperative day improved in group A. The extent of the improvement was more significant in the EN group compared with the PN group. ORR was 69.4% (43/62) in group A [complete response (CR), 4; partial response (PR), 39; and stable disease (SD), 19], 84.4% (27/32) in the EN group (CR, 3; PR, 24; and SD, 5) and 53.3% (16/30) in the PN group (CR, 1; PR, 15; and SD, 14). The excision rate and the radical excision rate in group A (85.5 and 45.2%) were significantly higher compared with group B (64.8 and 18.5%) (P<0.05). No difference was observed in pathological response rates between groups A and B, but the grade II+III pathological response rate was higher in the EN group (12/32) compared with the PN group (3/30). No significant difference was observed in the postoperative morbidity rate between group A (22.6%) and group B (33.3%) (P>0.05). The rate of postoperative gastric hypodynamics was higher in the PN group (10/30) compared with the EN group (5/32) (P<0.05). The authors concluded that nutritional support, particularly EN, could improve the nutritional status and quality of life in patients with gastric cancer complicated with GOO, and that preoperative chemotherapy plus nutritional support increased the rate of tumor excision. The information above was extracted from the full text of the original study written in Chinese.

Discussion

Gastric outlet obstruction, also known as pyloric obstruction, is defined as ‘the clinical and pathophysiological consequence of any disease process that produces a mechanical impediment to gastric emptying’ (Medscape) (15) or as ‘the hindering of output from the stomach into the small intestine’ (MeSH vocabulary thesaurus) (16), and is a frequently encountered impairment of gastric cancer patients in the clinical practice of medical and surgical oncologists. Individuals with GOO account for 31.6% of the gastric cancer patients (17).

Gastric cancer with GOO has a worse biological behavior. Chen et al (17) evaluated 551 gastric cancer patients with GOO and concluded that patients with this condition had a deeper cancer invasion and more lymph node metastases compared with those without. Similarly, Watanabe et al (18) conducted a clinicopathological study of gastric cancer with GOO, showing that these cancers were characterized by an infiltrating gross pattern and undifferentiated adenocarcinoma, and that these lesions showed a high incidence of serosal invasion, direct invasion into neighboring organs, peritoneal dissemination, lymph node metastasis and liver metastasis, as compared to the gastric cancers without GOO. These studies indicate that gastric cancers with GOO are generally in a more advanced stage.

Accordingly, gastric cancers with GOO have poor outcomes. Over two-thirds underwent palliative gastrojejunostomy without resection of the primary tumor or non-curative resection (18). The 5-year overall and disease-free survival rate of these patients were significantly lower compared with those without GOO (17). Thus, an improvement of the low curative resection rate and poor survival prognosis is required. As patients with GOO are in a more advanced stage, we hypothesize that this advanced condition may be a precise indication for preoperative chemotherapy.

However, the initial intervention for patients with GOO is more inclined to be surgical exploration instead of chemotherapy in clinical practice, past and present (18–26). For advanced gastric cancer patients, it is widely acknowledged that chemotherapy as an initial therapy is premised by the absence of ‘passage disturbance’ (24). Therefore, if there are GOO symptoms, chemotherapy is more likely to be applied postoperatively (24). Additionally, GOO is sometimes explicitly regarded as the exclusive criterion in the protocol of certain clinical trials concerning preoperative chemotherapy for gastric cancer (3). However, whether there is no possibility for the application of preoperative chemotherapy for gastric cancer patients with GOO remains to be explored. Therefore, whether dose chemotherapy as an initial intervention has potential clinical benefits equal to or different from surgery requires clarification. To explore this issue, the present literature review was conducted.

The multistage process and limited acquisition of the literature retrieval in the present study indicates that there is a modest number of medical practitioners implementing preoperative chemotherapy for gastric cancer patients with GOO. This may not be due to the unfeasibility of the mentioned treatment strategy, but due to the paucity of high-quality evidence to conclude whether chemotherapy as an initial treatment provided a clinical benefit that was equivalent to or better than that of surgery alone. However, certain valuable aspects can be extracted from these retrieved studies.

There was a potential feasibility of preoperative chemotherapy for GOO patients. Firstly, the 10 cases reported underwent chemotherapy for 2–6 cycles (6–14). The 13 individuals in the descriptive study (4) underwent gastrectomy following at least 2 cycles of drug therapy. The 62 subjects in the analytical study (5) received FOLFOX treatment by 2.7 cycles in average. These figures approximately met the number of preoperative chemotherapy cycles recommended in the NCCN guidelines (27). Secondly, of all the patients mentioned, only 2 cases suffering grade 3 neutropenia were reported with regards to the therapeutic toxicity (4), which indicated that the adverse effect of preoperative chemotherapy for GOO patients may be tolerable. Thirdly, not only the short-term outcomes, including tumor remission and radical effect on surgery, but also the long-term outcomes, namely the survival outcomes, were rather promising.

In conclusion, the aforementioned information indicate a potential feasibility of preoperative chemotherapy for gastric cancer patients with GOO. However, there may be an underlying publication bias, and the level of the evidence available is quite low. Therefore, prospective clinical trials providing qualified evidence are required to explore the feasibility, which is precisely what the present study aimed to induce and promote.

The literature also provided other information. Firstly, a variety of chemotherapeutic agents can be applied to explore the optimal regimens of preoperative chemotherapy for gastric cancer patients with GOO. Up to nine antitumor chemicals were involved in the 11 retrieved studies. Among them, the most frequently applied agent was fluoropyrimidines. Even S-1, with the enteral dosage form, was also medicated in 4 patients (6–8,10) perhaps via a nasointestinal feeding tube in the form of a water solution. Thus, the prevailing chemotherapy regimens for gastric cancer patients currently used in clinical practice and trials can be applicable candidates for intervention measures of future clinical trials in this scope.

Secondly, nutritional support treatment may be indispensable for patients with this condition. As is well known, inadequate intake of food and water is common for patients with GOO. Thus, malnutrition and dehydration are frequently encountered by these patients. In the retrospective cohort of the analytic study aforementioned, 62 patients received preoperative chemotherapy plus concurrently administered nutritional support. The serum level of albumin and quality of life score on the last preoperative day improved. Furthermore, the extent of the improvement was more significant in the EN group compared with the PN group (5). Thus, we hypothesize that nutritional support treatment is possibly a requisite for the basis of chemotherapy implementation.

Thirdly, locally advanced (M0) gastric cancer patients may be more preferred as subjects of preoperative chemotherapy. In the retrieved studies, M0 and far advanced (M1) patients with GOO were selected as the subjects of the treatment. As for the M0 patients, preoperative chemotherapy can be deemed as a neoadjuvant treatment, while for the M1 patients it may be considered as salvage or palliative therapy. In our opinion, preoperative chemotherapy is less beneficial and less necessary for M1 patients compared with M0 patients who may be potentially curable and have more chance of radical resection from preoperative treatment, as non-surgical management for relieving GOO symptoms of M1 individuals involves stent placement, which is palliative and not applicable to locally advanced subjects. With regards to the stent, it is not recommended for application to M0 gastric cancer patients in clinical practice and trials on account of its indication for patients with short life expectancies (28,29). Thus, candidates recruited in future clinical trials can be assigned as locally advanced gastric cancer patients complicated with GOO instead of far advanced patients.

Finally, the definitive roles of preoperative chemotherapy in relieving GOO and improving surgical and survival outcomes remain unclear. Among the patients involved in the referred case reports, GOO was relieved in 5 patients following preoperative chemotherapy (8–10,12,13), while it remained in 2 (11,14) and developed in 3 (6,7). Comparative analysis concerning survival outcomes between the preoperative chemotherapy group and the surgery only group is unavailable in either the descriptive (5) or the analytic study (4). Thus, there is a necessity to conduct controlled studies to evaluate the virtual beneficial effect of preoperative chemotherapy for gastric cancer patients with GOO.

On account of the paucity of clinical research in this area, pilot studies prospectively conducted are in demand to explore the feasibility, safety and efficacy of preoperative chemotherapy for locally advanced gastric cancer patients with GOO. In future stage II clinical trials, which can be defined as ‘feasibility studies’, candidates can be allocated into the single-arm cohort without a control group. Once the feasibility is confirmed by stage II trials, stage III controlled studies with double arms can be carried out to further evaluate the short-term and long-term outcomes.

The GOO patients with distant metastasis (M1), namely far advanced cases, are usually the subjects of salvage or palliative treatment, and have no possibility or necessity of radical resection, while the M0 cases are appropriate candidates for initial surgical intervention or initial chemotherapeutic treatment. Therefore, subjects included in future trials can be assigned as locally advanced gastric cancer patients with GOO.

Intervention measures of such types of trials can be preoperative chemotherapy with prevailing regimens that are currently widely used in gastric cancer treatment. By contrast, nutritional support can be employed as a basic premise of chemotherapy. Enteral versus parenteral nutritional support can also be evaluated as to which is more beneficial to the premise of chemotherapy. However, whether EN imposes a more significant influence compared with PN in this situation remains to be studied, while EN has been proven to be more beneficial in other situations (30,31). The initiation of the EN approach for patients with GOO varies from stent placement to nasojejunal feeding tube placement. The former is not recommended to be applied in trials of preoperative chemotherapy on account of its indication for patients with short life expectancies (28,29), while the latter can be adopted to conduct EN treatment for candidates in clinical trials of preoperative chemotherapy for locally advanced gastric cancer patients with GOO.

Short-term study endpoints should also be determined. Firstly, the improvement of GOO symptoms can be employed as one of the main short-term endpoints. To determine the extent of the improvement, the level of oral intake prior and subsequent to the treatment can be measured by the Gastric Outlet Obstruction Scoring System (GOOSS) (32). The clinical success of the treatment can be defined as an ability to tolerate at least liquid food (GOOSS score 1). Secondly, radiological ORR or disease control rate (DCR) according to the Response Evaluation Criteria in Solid Tumors (RECIST 1.1) (33) based on primary tumor reduction in computed tomography scans or magnetic resonance images can also be used as a main short-term objective to evaluate the efficacy. Thus far, there is an indication from the retrieved case reports that relief of GOO symptoms was not always concomitant with radiological response (6,11,14). Accordingly, a ‘novel ORR’ or ‘novel DCR’ applied to future clinical trials of preoperative chemotherapy for gastric cancer patients with GOO can be defined not only as CR plus PR, (and SD for DCR) according to the RECIST, but also as improvement of GOO symptoms. Thirdly, secondary endpoints, including resection rate or complete resection rate, histopathological tumor regression according to the Becker criteria (34), improvement of patients' pre- and post-intervention plasma albumin level, body mass index, the Eastern Cooperative Oncology Group Performance Status (also known as the WHO score) (35) and operative morbidity and mortality, can also be documented to evaluate the patients' short-term clinical outcomes.

In already published clinical trials regarding preoperative chemotherapy for gastric cancer patients, ORR varies from 27 to 74.4% (36–43), DCR from 78.9 to 100% (37,38,40,41) and R0 resection rate from 59 to 90.7% (36–38,40,41,43–45). In future trials on gastric cancer patients with GOO, if comparable outcomes can be achieved, it can be considered as promising results. A future treatment strategy for gastric cancer with GOO may therefore be further optimized in the field of short-term outcomes. Regardless, there is a possibility of disadvantageous results of such studies. In a multi-institutional retrospective Japanese study analyzing clinical outcomes for palliative gastrojejunostomy in unresectable advanced gastric cancer, prior chemotherapy was shown to be a significant independent predictor of poor survival (25). Although not a definitive conclusion, the result presented in the Japanese study did raise a different view in contrast to our expectation.

In conclusion, the paucity of high-quality literature in this area is perhaps the most significant finding of the literature review. Limited studies already published indicate a potential feasibility of preoperative chemotherapy for gastric cancer patients with GOO. However, the definitive role of chemotherapy as an initial treatment in relieving symptoms of GOO and improving other clinical outcomes remains unclear. Stage II and III clinical trials are expected to be conducted in order to probe into the authentic feasibility, safety and efficacy of preoperative chemotherapy for gastric cancer patients with GOO.

References