Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report

  • Authors:
    • Nobuhisa Matsuhashi
    • Takao Takahashi
    • Junko Kato
    • Toshiyuki Tanahashi
    • Satoshi Matsui
    • Yoshiyuki Sasaki
    • Hisashi Imai
    • Yoshihiro Tanaka
    • Naoki Okumura
    • Kazuya Yamaguchi
    • Manabu Futamura
    • Shinji Osada
    • Kazuhiro Yoshida
  • View Affiliations

  • Published online on: October 5, 2016     https://doi.org/10.3892/mco.2016.1045
  • Pages: 807-810
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Abstract

Pathological response to preoperative chemotherapy was recently found to be correlated with improved survival and has been proposed as a new outcome end‑point following resection of liver metastases from colorectal cancer (CRC). It was demonstrated that, particularly after therapy with bevacizumab, CRC liver metastases decreased in size and underwent distinct morphological changes on computed tomography (CT). However, morphological changes in response to treatment with regorafenib have not yet been reported. A 74‑year‑old male patient with synchronous multiple liver and lung metastases from colon cancer was treated with regorafenib as a fifth‑line therapy. CT imaging revealed a decrease in the tumor size and distinct morphological changes, namely homogeneous attenuation and sharp tumor‑liver interface. The patient continued to take regorafenib for 8 months. Thus, regorafenib appeared to be effective as a last‑line chemotherapy. In particular, the unique morphological changes of the metastases on CT imaging of may represent a method for evaluating the effects of crc cancer therapy.
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December-2016
Volume 5 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Matsuhashi N, Takahashi T, Kato J, Tanahashi T, Matsui S, Sasaki Y, Imai H, Tanaka Y, Okumura N, Yamaguchi K, Yamaguchi K, et al: Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report. Mol Clin Oncol 5: 807-810, 2016.
APA
Matsuhashi, N., Takahashi, T., Kato, J., Tanahashi, T., Matsui, S., Sasaki, Y. ... Yoshida, K. (2016). Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report. Molecular and Clinical Oncology, 5, 807-810. https://doi.org/10.3892/mco.2016.1045
MLA
Matsuhashi, N., Takahashi, T., Kato, J., Tanahashi, T., Matsui, S., Sasaki, Y., Imai, H., Tanaka, Y., Okumura, N., Yamaguchi, K., Futamura, M., Osada, S., Yoshida, K."Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report". Molecular and Clinical Oncology 5.6 (2016): 807-810.
Chicago
Matsuhashi, N., Takahashi, T., Kato, J., Tanahashi, T., Matsui, S., Sasaki, Y., Imai, H., Tanaka, Y., Okumura, N., Yamaguchi, K., Futamura, M., Osada, S., Yoshida, K."Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report". Molecular and Clinical Oncology 5, no. 6 (2016): 807-810. https://doi.org/10.3892/mco.2016.1045