Extravascular type of intravascular papillary endothelial hyperplasia mimicking parotid gland neoplasia and the possible role of ferritin in the pathogenesis: A case report

Mignogna,Chiara; Barca,Ida; Di Vito,Anna; Puleo,Francesca; Malara,Natalia; Giudice,Amerigo; Giudice,Mario; Barni,Tullio; Donato,Giuseppe; Cristofaro,Maria Giulia

doi:10.3892/mco.2016.1117

Extravascular type of intravascular papillary endothelial hyperplasia mimicking parotid gland neoplasia and the possible role of ferritin in the pathogenesis: A case report

Authors:
- Chiara Mignogna
- Ida Barca
- Anna Di Vito
- Francesca Puleo
- Natalia Malara
- Amerigo Giudice
- Mario Giudice
- Tullio Barni
- Giuseppe Donato
- Maria Giulia Cristofaro
View Affiliations

Affiliations: Department of Health Science, Magna Græcia University, I‑88100 Catanzaro, Italy, Department of Experimental and Clinical Medicine, Magna Græcia University, I‑88100 Catanzaro, Italy
Published online on: December 23, 2016 https://doi.org/10.3892/mco.2016.1117
Pages: 193-196

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Intravascular papillary endothelial hyperplasia (IPEH) is defined as a vascular lesion characterized by extensive proliferation of vascular endothelial cells. This lesion was first described by Pierre Masson in 1923 as intravascular hemangioendothelioma. The most frequent sites of involvement are the skin and subcutis. IPEH comprises ~2% of the vascular tumors of the skin and subcutaneous tissue and it has a predilection for the head, neck, trunk and the extremities. The diagnosis is based on histopathology. We herein present the second case of Masson's tumor of the parotid gland described in literature. The patient was a 70-year-old female. Magnetic resonance imaging revealed an irregular lesion with smooth margins, initially considered to be compatible with pleomorphic adenoma. Immunohistochemical analysis revealed positivity of the tumor cells for ferritin heavy and light chains, vimentin and CD31. The aim of the present study was to emphasize the immunohistochemical characteristics and briefly discuss the potential role of ferritin in the pathogenesis of IPEH.

View Figures

View References

1	Luce EB, Montgomery MT, Redding SW and Aufdemorte TB: Intravascular angiomatosis (Masson's lesion). J Oral Maxillofac Surg. 46:736–741. 1988. View Article : Google Scholar : PubMed/NCBI
2	Kuo T, Sayers CP and Rosai J: Masson's ‘vegetant intravascular hemangioendothelioma’: a lesion often mistaken for angiosarcoma: study of seventeen cases located in the skin and soft tissues. Cancer. 38:1227–1236. 1976. View Article : Google Scholar : PubMed/NCBI
3	Escasany R Torne and Millet P Umbert: Masson's pseudoangiosarcoma of the tongue: Report of two cases. J Cutan Pathol. 12:66–71. 1985. View Article : Google Scholar : PubMed/NCBI
4	Masson P: Hèmangioendothèliome vègètant intravasculaire. Bull Soc Anat Paris. 93:517–523. 1923.
5	Tosios K, Koutlas IG and Papanicolaou SI: Intravascular papillary endothelial hyperplasia of the oral soft tissues: Report of 18 cases and review of the literature. J Oral Maxillofac Surg. 52:1263–1268. 1994. View Article : Google Scholar : PubMed/NCBI
6	Hutcheson EL, Picarella EA and Blevins PK: Masson's tumor of the hand: a case report and brief literature review. Ann is Plast Surg. 69:338–339. 2012. View Article : Google Scholar
7	Tedla M, Bežová M, Biró C, Tedlová E, Eng CY and Zeleník K: Intravascular papillary endothelial hyperplasia of larynx: Case report and literature review of all head and neck cases. Otolaryngol Pol. 68:200–203. 2014. View Article : Google Scholar : PubMed/NCBI
8	Moon WS, Chung GH and Hong KH: Intravascular papillary endothelial hyperplasia in a vascular lesion of the paranasal sinus. Arch Pathol Lab Med. 124:1224–1227. 2000.PubMed/NCBI
9	Makos CP and Nikolaidou AJ: Intravascular papillary endothelial hyperplasia (Masson's tumor) of oral mucosa. Presentation of two cases and review. Oral Oncol Extra. 40:59–62. 2004. View Article : Google Scholar
10	Murugaraj V, Kingston GT, Patel M and Anand R: Intravascular papillary endothelial hyperplasia (Masson's tumour) of the oral mucosa. Br J Oral Maxillofac Surg. 48:e16–e17. 2010. View Article : Google Scholar : PubMed/NCBI
11	Sarode GS, Sarode SC and Karmarkar SP: Oral intravascular papillary endothelial hyperplasia (Masson's tumor): A review of literature. J Oral Maxillofac Surg Med Pathol. 26:73–79. 2014. View Article : Google Scholar
12	Hashimoto H, Daimaru Y and Enjoji M: Intravascular papillary endothelial hyperplasia. A clinicopathologic study of 91 cases. Am J Dermatopathol. Dec;5(6): 539–546. 1983. View Article : Google Scholar : PubMed/NCBI
13	Akdur NC, Donmez M, Gozel S, Ustun H and Hucumenoglu S: Intravascular papillary endothelial hyperplasia: Histomorphological and immunohistochemical features. Diagn Pathol. 8:1672013. View Article : Google Scholar : PubMed/NCBI
14	Guledgud MV, Patil K, Saikrishna D, Madhavan A and Yelamali T: Intravascular papillary endothelial hyperplasia: Diagnostic sequence and literature review of an orofacial lesion. Case Rep Dent. 2014:9345932014.PubMed/NCBI
15	Zolea F, Biamonte F, Candeloro P, Di Sanzo M, Cozzi A, Di Vito A, Quaresima B, Lobello N, Trecroci F, Di Fabrizio E, et al: H ferritin silencing induces protein misfolding in K562 cells: A Raman analysis. Free Radic Biol Med. 89:614–623. 2015. View Article : Google Scholar : PubMed/NCBI
16	Meyron-Holtz EG, MosheBelizowski S and Cohen LA: A possible role for secreted ferritin in tissue iron distribution. J Neural Transm Vienna. 118:337–347. 2011. View Article : Google Scholar : PubMed/NCBI
17	Alkhateeb AA and Connor JR: The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis. Biochim Biophys Acta. 1836:245–254. 2013.PubMed/NCBI
18	Rogers JT, Bridges KR, Durmowicz GP, Glass J, Auron PE and Munro HN: Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1. J Biol Chem. 265:14572–14578. 1990.PubMed/NCBI
19	Tesfay L, Huhn AJ, Hatcher H, Torti FM, Torti SV and Ahmir A: Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells. PLoS One. 7:e400302012. View Article : Google Scholar : PubMed/NCBI
20	Cristofaro MG, Allegra E, Giudice A, Colangeli W, Caruso D, Barca I and Giudice M: Pleomorphic adenoma of the parotid: Extracapsular dissection compared with superficial parotidectomy-a 10-year retrospective cohort study. Sci World J. 2014:5640532014. View Article : Google Scholar
21	Henschen F: L'endovasculite proliférante thrombopoïétique dans la lesion vasculaire locale. Ann Anat Path. 9:113–121. 1932.
22	Csank GA and Curletti EL: Intravascular papillary endothelial hyperplasia: Challenge in diagnosis and vascular reconstruction-a case report. Vasc Endovascular Surg. 32:295–299. 1998. View Article : Google Scholar
23	Levere SM, Barsky SH and Meals RA: Intravascular papillary endothelial hyperplasia: A neoplastic ‘actor’ representing an exaggerated attempt at recanalization mediated by basic fibroblast growth factor. J Hand Surg Am. 19:559–564. 1994. View Article : Google Scholar : PubMed/NCBI
24	Buchner A, Merrell PW, Carpenter WM and Leider AS: Oral intravascular papillary endothelial hyperplasia. J Oral Pathol Med. 19:419–422. 1990. View Article : Google Scholar : PubMed/NCBI
25	Albrecht S and Kahn HJ: Immunohistochemistry of intravascular papillary endothelial hyperplasia. J Cutan Pathol. 17:16–21. 1990. View Article : Google Scholar : PubMed/NCBI
26	Katzman B, Caligiuri DA, Klein DM, Nicastri AD and Chen P: Recurrent intravascular papillary endothelial hyperplasia. J Hand Surg [Br]. 22:113–115. 1997. View Article : Google Scholar : PubMed/NCBI
27	Coffman LG, Parsonage D, D'Agostino R Jr, Torti FM and Torti SV: Regulatory effects of ferritin on angiogenesis. Proc Natl Acad Sci USA. 106:570–575. 2009. View Article : Google Scholar : PubMed/NCBI