Efficacy and safety of oxaliplatin, bevacizumab and oral S‑1 for advanced recurrent colorectal cancer

  • Authors:
    • Shuji Suzuki
    • Jiro Shimazaki
    • Keiichi Morishita
    • Nobusada Koike
    • Nobuhiko Harada
    • Tsuneo Hayashi
    • Mamoru Suzuki
  • View Affiliations

  • Published online on: August 4, 2016     https://doi.org/10.3892/mco.2016.977
  • Pages: 391-394
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Abstract

The aim of this study was to evaluate the efficacy and safety of co‑administration of oral S-1 and oxaliplatin (SOX) in combination with bevacizumab (bev) in patients with advanced recurrent colorectal cancer. A retrospective study of 36 patients with advanced recurrent colorectal cancer was performed, of whom 27 received first‑line and 9 received second‑line SOX+bev chemotherapy between 2010 and 2013 at the Hachioji Digestive Disease Hospital (Hachioji, Japan). The SOX+bev regimen consisted of administration of intravenous oxaliplatin (85 mg/m2) on days 1 and 14, bevacizumab (5 mg/kg) on day 1, and co‑administration of oral S‑1 twice daily on days 1-14. The drug regimen was repeated every 4 weeks. SOX+bev treatment was associated with a response rate of 45.2%, a disease control rate of 71%, and a median progression‑free survival (PFS) and overall survival (OS) of 9.9 and 21.9 months, respectively. Patients who received first‑line chemotherapy benefited from treatment in terms of prolonged PFS (13.8 months) and OS (28.2 months). Grade 3/4 adverse events were infrequent and included anaemia, thrombocytopenia, anorexia, diarrhea, sensory neuropathy, increased aspartate aminotransferase level and skin rash. In conclusion, SOX+bev therapy was found to be feasible and safe for patients with advanced and recurrent colorectal cancer.
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October-2016
Volume 5 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Suzuki S, Shimazaki J, Morishita K, Koike N, Harada N, Hayashi T and Suzuki M: Efficacy and safety of oxaliplatin, bevacizumab and oral S‑1 for advanced recurrent colorectal cancer. Mol Clin Oncol 5: 391-394, 2016
APA
Suzuki, S., Shimazaki, J., Morishita, K., Koike, N., Harada, N., Hayashi, T., & Suzuki, M. (2016). Efficacy and safety of oxaliplatin, bevacizumab and oral S‑1 for advanced recurrent colorectal cancer. Molecular and Clinical Oncology, 5, 391-394. https://doi.org/10.3892/mco.2016.977
MLA
Suzuki, S., Shimazaki, J., Morishita, K., Koike, N., Harada, N., Hayashi, T., Suzuki, M."Efficacy and safety of oxaliplatin, bevacizumab and oral S‑1 for advanced recurrent colorectal cancer". Molecular and Clinical Oncology 5.4 (2016): 391-394.
Chicago
Suzuki, S., Shimazaki, J., Morishita, K., Koike, N., Harada, N., Hayashi, T., Suzuki, M."Efficacy and safety of oxaliplatin, bevacizumab and oral S‑1 for advanced recurrent colorectal cancer". Molecular and Clinical Oncology 5, no. 4 (2016): 391-394. https://doi.org/10.3892/mco.2016.977