Updated recommendation on molecular-targeted therapy for metastatic renal cell cancer

  • Authors:
    • Senji Hoshi
    • Kenji Numahata
    • Hidenori Kanno
    • Masahiko Sato
    • Akihito Kuromoto
    • Kunihisa Nezu
    • Takanari Sakai
    • Chihito Konno
    • Yuichi Ishizuka
    • Hideaki Izumi
    • Katsuyuki Taguchi
    • Kunio Ono
    • Kiyotsugu Hoshi
    • Satoshi Kanto
    • Rika Takahashi
    • Bilim Vladimir
    • Naoe Akimoto
    • Isoji Sasagawa
    • Shoichiro Ohta
  • View Affiliations

  • Published online on: August 11, 2017     https://doi.org/10.3892/mco.2017.1371
  • Pages:591-594
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Abstract

Molecular-targeted therapy was recommended for the systemic therapy of renal cell cancer (RCC) in the RCC guidelines, but these guidelines do not address the order of administration of the multiple presently available agents. There are several aspects that remain unknown regarding the optimal administration order and combination of molecular‑targeted drugs. Until the optimal treatment sequence is determined by clinical trials, treatment individualization is required for each patient based on patient and disease characteristics. We herein investigate 12 cases of RCC patients who received axitinib. Axitinib was used as the first‑line drug in 4 cases, second‑line in 5 cases, third‑line in 1 case and as a fourth‑line drug in 2 cases. Partial response (PR) was observed in 4 cases (30%) and stable disease in 4 cases (30%) during axitinib treatment, with an overall response rate of 60%. The duration of PR ranged from 6 to 19 months. Based on our cases, axitinib exhibited reasonable therapeutic efficacy as first‑ as well as second‑line treatment. However, more cases are required to draw firm conclusions.

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October 2017
Volume 7 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
APA
Hoshi, S., Numahata, K., Kanno, H., Sato, M., Kuromoto, A., Nezu, K. ... Ohta, S. (2017). Updated recommendation on molecular-targeted therapy for metastatic renal cell cancer. Molecular and Clinical Oncology, 7, 591-594. https://doi.org/10.3892/mco.2017.1371
MLA
Hoshi, S., Numahata, K., Kanno, H., Sato, M., Kuromoto, A., Nezu, K., Sakai, T., Konno, C., Ishizuka, Y., Izumi, H., Taguchi, K., Ono, K., Hoshi, K., Kanto, S., Takahashi, R., Vladimir, B., Akimoto, N., Sasagawa, I., Ohta, S."Updated recommendation on molecular-targeted therapy for metastatic renal cell cancer". Molecular and Clinical Oncology 7.4 (2017): 591-594.
Chicago
Hoshi, S., Numahata, K., Kanno, H., Sato, M., Kuromoto, A., Nezu, K., Sakai, T., Konno, C., Ishizuka, Y., Izumi, H., Taguchi, K., Ono, K., Hoshi, K., Kanto, S., Takahashi, R., Vladimir, B., Akimoto, N., Sasagawa, I., Ohta, S."Updated recommendation on molecular-targeted therapy for metastatic renal cell cancer". Molecular and Clinical Oncology 7, no. 4 (2017): 591-594. https://doi.org/10.3892/mco.2017.1371