Human immunodeficiency virus‑negative multicentric Castleman's disease coexistent with Kaposi's sarcoma on 18F‑FDG PET/CT: A case report
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- Published online on: December 11, 2018 https://doi.org/10.3892/mco.2018.1789
- Pages: 318-320
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Abstract
Multicentric Castleman's disease and Kaposi's sarcoma are more frequently observed in human immunodeficiency virus (HIV)‑infected patients; however, 40‑50% of the cases are HIV‑negative. The present study reports the case of a 61‑year‑old man who presented with palpable masses in the axillary and right inguinal areas. The blood test results revealed increased serum erythrocyte sedimentation rate and C‑reactive protein level, with negative serological markers, including for HIV. The patient was investigated using contrast‑enhanced computed tomography (CT) and fluorine‑ 18fluorodeoxyglucose positron emission tomography (18F‑FDG PET)/CT; the images revealed multiple enlarged and intensely hypermetabolic lymph nodes in the cervical, thoracic and abdominopelvic areas. Excisional biopsy and immunohistochemical analysis were performed, which confirmed the diagnosis of HIV‑negative multicentric Castleman's disease coexisting with Kaposi's sarcoma. The patient received steroid therapy followed by chemotherapy. After 4 cycles of chemotherapy, the follow‑up 18F‑FDG PET/CT scan revealed nearly complete remission of the hypermetabolic malignant lesions of the neck, axilla and thoracoabdominal region.
