Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population

Govind,Pallavi; Pavethynath,Shilpa; Sawabe,Motoji; Arai,Tomio; Muramatsu,Masaaki

doi:10.3892/mco.2020.2021

Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population

Authors:
- Pallavi Govind
- Shilpa Pavethynath
- Motoji Sawabe
- Tomio Arai
- Masaaki Muramatsu
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Affiliations: Faculty of Medicine, Imperial College London, London SW7 2AZ, UK, Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113‑8510, Japan, Department of Molecular Pathology, Tokyo Medical and Dental University, Tokyo 113‑8510, Japan, Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173‑0015, Japan
Published online on: March 24, 2020 https://doi.org/10.3892/mco.2020.2021
Pages: 503-510
Copyright: © Govind et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Alcohol consumption is an established risk factor for cancer, but little is known regarding the effect of genetic polymorphisms in alcohol metabolism genes on alcohol‑related cancer risk in the Japanese population. Associations between the ADH1B gene (alcohol dehydrogenase 1B), single nucleotide polymorphism (SNP) rs1229984 and cancer have been extensively studied yet evidence is inconsistent. This population‑based case‑control study primarily aimed to clarify any association between SNP rs1229984 in both overall and specific cancer risk in a Japanese population. The functional non‑synonymous SNP rs1229984 (Arg48His) was genotyped using DNA samples from 1,359 consecutive autopsy cases registered in The Japanese Single Nucleotide Polymorphisms for Geriatric Research database. Medical and pathological record data from this database were used to categorise cases and controls. Results included 1,359 participants, 816 cases and 543 controls. Multinomial logistic regression analyses showed no significant association between rs1229984 presence and overall cancer risk in both dominant and recessive genetic inheritance models [Arg/Arg+Arg/His vs. His/His: Adjusted odds ratio (OR)=0.66 (95% CI=0.39‑1.13; P=0.129), Arg/Arg vs. Arg/His+His/His: OR=0.95 (95% CI=0.75‑1.20; P=0.657)]. However, results showed those homozygous for rs1229984 (genotype His/His) were at significantly decreased odds of lung cancer than other genotypes [recessive model: OR=0.64 (95% CI=0.44‑0.93; P=0.020]. In conclusion, there was no significant association between rs1229984 and odds of overall or specific cancers except in lung cancer where His/His genotype decreased odds. To the best of our knowledge, the association between His/His and decreased odds of lung cancer is a novel finding. These findings require further validation in larger studies.

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