Fournier's gangrene during lenvatinib treatment: A case report

  • Authors:
    • Martina Barone
    • Giorgio Grani
    • Valeria Ramundo
    • Tiziana Garritano
    • Cosimo Durante
    • Rosa Falcone
  • View Affiliations

  • Published online on: April 10, 2020     https://doi.org/10.3892/mco.2020.2031
  • Pages: 588-591
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Abstract

Fournier's gangrene is a rare and severe complication reported in patients with cancer treated with antiangiogenic drugs, most frequently with bevacizumab. The present report describes the case of an 80‑year‑old man with radioactive iodine‑refractory metastatic thyroid cancer treated with lenvatinib (an oral multikinase inhibitor with antiangiogenic properties) who developed Fournier's gangrene in the absence of other known risk factors. To the best of our knowledge, this is the first case described during treatment with lenvatinib. The condition was likely due to a perturbation of vascular endothelial cells of the skin due to the inhibition of VEGF/VEGFR signaling. Fournier's gangrene may be a class effect of antiangiogenic treatment that clinicians should be aware of, as early diagnosis and treatment are associated with an improved outcome.
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June-2020
Volume 12 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Barone M, Grani G, Ramundo V, Garritano T, Durante C and Falcone R: Fournier's gangrene during lenvatinib treatment: A case report. Mol Clin Oncol 12: 588-591, 2020.
APA
Barone, M., Grani, G., Ramundo, V., Garritano, T., Durante, C., & Falcone, R. (2020). Fournier's gangrene during lenvatinib treatment: A case report. Molecular and Clinical Oncology, 12, 588-591. https://doi.org/10.3892/mco.2020.2031
MLA
Barone, M., Grani, G., Ramundo, V., Garritano, T., Durante, C., Falcone, R."Fournier's gangrene during lenvatinib treatment: A case report". Molecular and Clinical Oncology 12.6 (2020): 588-591.
Chicago
Barone, M., Grani, G., Ramundo, V., Garritano, T., Durante, C., Falcone, R."Fournier's gangrene during lenvatinib treatment: A case report". Molecular and Clinical Oncology 12, no. 6 (2020): 588-591. https://doi.org/10.3892/mco.2020.2031