Open Access

Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis

  • Authors:
    • Mubarak Al‑Mansour
    • Meteb Al‑Foheidi
    • Ezzeldin Ibrahim
  • View Affiliations

  • Published online on: July 29, 2020     https://doi.org/10.3892/mco.2020.2103
  • Article Number: 33
  • Copyright: © Al‑Mansour et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Diffuse large B‑cell lymphoma (DLBCL) is the most common subtype of non‑Hodgkin's lymphoma (NHL), representing 30% of all lymphoma cases. Within the first 2‑3 years following immunochemotherapy, 30‑40% of patients will experience a relapse or a refractory disease, thereby exhibiting a poor prognosis. High‑dose immunotherapy followed by autologous stem cell transplantation is the standard care for relapsed/refractory (RR) patients with DLBCL. However, >60% of patients are ineligible for a transplant, presenting a therapeutic challenge. Chimeric antigen receptor (CAR) T‑cell therapy has shown promising efficacy in patients with DLBCL, including those with R/R disease. The present study conducted a meta‑analysis that showed highly favorable outcomes [objective response rate (ORR): 69%; complete remission (CR): 49%] in B‑cell NHL patients (n=419) who were treated with second‑generation CAR T cells. The response rate varied in different types of B‑cell NHL. In 306 patients with R/R DLBCL eligible for rate evaluation, the ORR and CR rate mean estimates were 68% [95% confidence interval (CI), 55‑79%] and 46% (95% CI, 38‑54%), respectively. Thus, the findings indicated that immunotherapy with CAR T cells has improved outcomes for patients with R/R DLBCL and other subtypes of B‑cell NHL compared with standard chemotherapy regimens. The study revealed that grade ≥3 anemia (34%) and thrombocytopenia (30%) were the most common adverse effects of CAR T‑cell therapy. Incidence of grade ≥3 cytokine release syndrome and neurotoxicity associated with CAR T‑cell therapy was effectively managed.
View Figures
View References

Related Articles

Journal Cover

October-2020
Volume 13 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Al‑Mansour M, Al‑Foheidi M and Ibrahim E: Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis. Mol Clin Oncol 13: 33, 2020.
APA
Al‑Mansour, M., Al‑Foheidi, M., & Ibrahim, E. (2020). Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis. Molecular and Clinical Oncology, 13, 33. https://doi.org/10.3892/mco.2020.2103
MLA
Al‑Mansour, M., Al‑Foheidi, M., Ibrahim, E."Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis". Molecular and Clinical Oncology 13.4 (2020): 33.
Chicago
Al‑Mansour, M., Al‑Foheidi, M., Ibrahim, E."Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis". Molecular and Clinical Oncology 13, no. 4 (2020): 33. https://doi.org/10.3892/mco.2020.2103