Open Access

Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker

  • Authors:
    • Tatsuki Nanami
    • Isamu Hoshino
    • Fumiaki Shiratori
    • Satoshi Yajima
    • Yoko Oshima
    • Takashi Suzuki
    • Masaaki Ito
    • Takaki Hiwasa
    • Akiko Kuwajima
    • Hideaki Shimada
  • View Affiliations

  • Published online on: July 1, 2021     https://doi.org/10.3892/mco.2021.2341
  • Article Number: 179
  • Copyright: © Nanami et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although serum galectin‑1 antibodies (s‑GAL‑1‑Abs) have been evaluated in a small number of patients with cancer, a large series of patients with different cancer types have not been reported. The current study evaluated 1,833 patients with esophageal cancer (n=172), gastric cancer (n=317), colorectal cancer (n=262), hepatocellular carcinoma (n=91), prostate cancer (n=358), breast cancer (n=364), lung cancer (n=269) and 72 healthy individuals. s‑GAL‑1‑Abs levels were analyzed using an originally developed ELISA system. A cut‑off optical density value was determined as the mean (0.053) + 3 standard deviations (0.105) of sera from healthy controls. The results revealed that the positive rate of s‑GAL‑1‑Abs in patients with hepatocellular carcinoma (16.7%) and lung cancer (13.8%) were significantly higher compared with the other groups: Esophageal cancer (11.6%), colorectal cancer (11.5%), prostate cancer (7.3%), gastric cancer (6.9%), breast cancer (6.9%) and healthy controls (4.2%). Although the positive rates of s‑GAL‑1‑Abs in different cancer types were relatively low, s‑GAL‑1‑Abs may be useful for patients with hepatocellular carcinoma and lung cancer.
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September-2021
Volume 15 Issue 3

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Spandidos Publications style
Nanami T, Hoshino I, Shiratori F, Yajima S, Oshima Y, Suzuki T, Ito M, Hiwasa T, Kuwajima A, Shimada H, Shimada H, et al: Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker. Mol Clin Oncol 15: 179, 2021
APA
Nanami, T., Hoshino, I., Shiratori, F., Yajima, S., Oshima, Y., Suzuki, T. ... Shimada, H. (2021). Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker. Molecular and Clinical Oncology, 15, 179. https://doi.org/10.3892/mco.2021.2341
MLA
Nanami, T., Hoshino, I., Shiratori, F., Yajima, S., Oshima, Y., Suzuki, T., Ito, M., Hiwasa, T., Kuwajima, A., Shimada, H."Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker". Molecular and Clinical Oncology 15.3 (2021): 179.
Chicago
Nanami, T., Hoshino, I., Shiratori, F., Yajima, S., Oshima, Y., Suzuki, T., Ito, M., Hiwasa, T., Kuwajima, A., Shimada, H."Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker". Molecular and Clinical Oncology 15, no. 3 (2021): 179. https://doi.org/10.3892/mco.2021.2341