Open Access

Transition of the PD‑1 occupancy of nivolumab on T cells after discontinuation and response of nivolumab re‑challenge

  • Authors:
    • Taku Nose
    • Yohei Funakoshi
    • Hirotaka Suto
    • Yoshiaki Nagatani
    • Yoshinori Imamura
    • Masanori Toyoda
    • Naomi Kiyota
    • Hironobu Minami
  • View Affiliations

  • Published online on: April 12, 2022     https://doi.org/10.3892/mco.2022.2537
  • Article Number: 104
  • Copyright: © Nose et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although nivolumab is administered every two or four weeks, high programmed cell death‑1 (PD‑1) binding of nivolumab on T cells lasting for several months has been reported. A relationship between the PD‑1 occupancy rate on T‑cells and the efficacy of nivolumab is not yet fully understood. The present study used flow cytometric analyses to determine the time‑dependence of PD‑1 occupancy in five patients who discontinued nivolumab. The relationship between PD‑1 occupancy at relapse and the efficacy of re‑challenge was also studied. Occupancies after discontinuation were measured at a total of 32 points. The data indicated that it took 32.4 and 48.9 weeks to decrease occupancy by 50 and 70%, respectively. Subsequently, two patients had recurrence and were re‑challenged with nivolumab. At that time, one patient had 70.8% occupancy while the other had 6.6%. Treatment was effective only for the patient with lower occupancy. Overall, the present study suggests that re‑challenge with nivolumab may be efficacious in patients with low occupancy at recurrence.
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May-2022
Volume 16 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Nose T, Funakoshi Y, Suto H, Nagatani Y, Imamura Y, Toyoda M, Kiyota N and Minami H: Transition of the PD‑1 occupancy of nivolumab on T cells after discontinuation and response of nivolumab re‑challenge. Mol Clin Oncol 16: 104, 2022.
APA
Nose, T., Funakoshi, Y., Suto, H., Nagatani, Y., Imamura, Y., Toyoda, M. ... Minami, H. (2022). Transition of the PD‑1 occupancy of nivolumab on T cells after discontinuation and response of nivolumab re‑challenge. Molecular and Clinical Oncology, 16, 104. https://doi.org/10.3892/mco.2022.2537
MLA
Nose, T., Funakoshi, Y., Suto, H., Nagatani, Y., Imamura, Y., Toyoda, M., Kiyota, N., Minami, H."Transition of the PD‑1 occupancy of nivolumab on T cells after discontinuation and response of nivolumab re‑challenge". Molecular and Clinical Oncology 16.5 (2022): 104.
Chicago
Nose, T., Funakoshi, Y., Suto, H., Nagatani, Y., Imamura, Y., Toyoda, M., Kiyota, N., Minami, H."Transition of the PD‑1 occupancy of nivolumab on T cells after discontinuation and response of nivolumab re‑challenge". Molecular and Clinical Oncology 16, no. 5 (2022): 104. https://doi.org/10.3892/mco.2022.2537