Open Access

Prognostic value of serum CEA and CA19‑9 levels in pancreatic ductal adenocarcinoma

  • Authors:
    • Eramah Ermiah
    • Mona Eddfair
    • Othman Abdulrahman
    • Mohamed Elfagieh
    • Abdalla Jebriel
    • Mona Al-Sharif
    • Mourad Assidi
    • Abdelbaset Buhmeida
  • View Affiliations

  • Published online on: June 16, 2022     https://doi.org/10.3892/mco.2022.2559
  • Article Number: 126
  • Copyright: © Ermiah et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study investigated the associations of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19‑9 (CA19‑9) levels with clinicopathological variables and survival outcomes in Libyan patients with pancreatic ductal adenocarcinoma (PDAC). The clinicopathological variables of 123 patients with PDAC registered at the National Cancer Institute in Misurata, Libya, between 2010 and 2018 were retrospectively analyzed. Blood samples from these patients were analyzed for serum CEA and CA19‑9 levels before treatment by electrochemiluminescence immunoassay (double antibody sandwich ELISA) on a Roche cobas e 602 modules. The relationships between CA19‑9 and CEA serum levels with clinicopathologic variables and survival outcomes were analyzed using the Kaplan‑Meier method, log‑rank test and Cox regression analyzes. Cut‑off values for serum CEA and CA19‑9 levels were 5 ng/ml and 400 U/ml, respectively. The median serum levels of all patients with PDAC for CEA and CA19‑9 were 8 ng/ml (1.1‑377 ng/ml) and 389 U/ml (1‑10,050 U/ml), respectively. Tumors with higher serum CEA and CA19‑9 levels were found in 63 and 48% of patients, respectively. Higher CEA and CA19‑9 serum levels were significantly associated with more indicators of a malignant phenotype, including a surgically unresectable tumor, unevaluable lymph nodes, advanced stages and distant metastases. Regarding survival, patients with higher serum levels of the biomarkers CEA and CA19‑9 had shorter overall survival rates (P<0.016 and (P<0.014, log‑rank, respectively) and lower disease‑free survival rates (P<0.002 and P<0.0001, log‑rank, respectively). The present study demonstrated significant clinical and prognostic value of serum levels of biomarkers CEA and CA19‑9 for Libyan patients with PDAC. Moreover, patients with PDAC with higher serum CEA and CA19‑9 levels had more aggressive tumors, higher rates of disease recurrence and shorter overall survival rates and thus required more vigilant follow‑up. Further multinational studies with larger PDAC cohorts are warranted to confirm these findings in terms of improved clinical decision making, more effective management and improved survival.
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August-2022
Volume 17 Issue 2

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Spandidos Publications style
Ermiah E, Eddfair M, Abdulrahman O, Elfagieh M, Jebriel A, Al-Sharif M, Assidi M and Buhmeida A: Prognostic value of serum CEA and CA19‑9 levels in pancreatic ductal adenocarcinoma. Mol Clin Oncol 17: 126, 2022.
APA
Ermiah, E., Eddfair, M., Abdulrahman, O., Elfagieh, M., Jebriel, A., Al-Sharif, M. ... Buhmeida, A. (2022). Prognostic value of serum CEA and CA19‑9 levels in pancreatic ductal adenocarcinoma. Molecular and Clinical Oncology, 17, 126. https://doi.org/10.3892/mco.2022.2559
MLA
Ermiah, E., Eddfair, M., Abdulrahman, O., Elfagieh, M., Jebriel, A., Al-Sharif, M., Assidi, M., Buhmeida, A."Prognostic value of serum CEA and CA19‑9 levels in pancreatic ductal adenocarcinoma". Molecular and Clinical Oncology 17.2 (2022): 126.
Chicago
Ermiah, E., Eddfair, M., Abdulrahman, O., Elfagieh, M., Jebriel, A., Al-Sharif, M., Assidi, M., Buhmeida, A."Prognostic value of serum CEA and CA19‑9 levels in pancreatic ductal adenocarcinoma". Molecular and Clinical Oncology 17, no. 2 (2022): 126. https://doi.org/10.3892/mco.2022.2559