Metaplastic breast carcinoma producing prominent basal lamina with neuroendocrine differentiation: A case report

Furuya,Yoshitaka; Hiroshima,Kenzo; Wakahara,Takashi; Akimoto,Harutoshi; Kawai,Shigeo; Ota,Masayuki; Nakatani,Yukio; Furuya,Akinori; Yanagie,Hironobu

doi:10.3892/mco.2023.2632

Metaplastic breast carcinoma producing prominent basal lamina with neuroendocrine differentiation: A case report

Authors:
- Yoshitaka Furuya
- Kenzo Hiroshima
- Takashi Wakahara
- Harutoshi Akimoto
- Shigeo Kawai
- Masayuki Ota
- Yukio Nakatani
- Akinori Furuya
- Hironobu Yanagie
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Affiliations: Department of Surgery, Sodegaura Satsukidai Hospital, Sodegaura, Chiba 299‑0246, Japan, Department of Pathology, Sodegaura Satsukidai Hospital, Sodegaura, Chiba 299‑0246, Japan, Department of Diagnostic Pathology, Tochigi Medical Center Shimotsuga, Tochigi, Tochigi 329‑4498, Japan, Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Chiba 260‑8670, Japan, Department of Pathology, Yokosuka Kyosai Hospital, Yokosuka, Kanagawa 238‑0011, Japan, Faculty of Science and Engineering, Tokushima Bunri University, Sanuki, Kagawa 769‑2193, Japan, Research Institute of Healthy Living, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Niigata 956‑8603, Japan
Published online on: March 10, 2023 https://doi.org/10.3892/mco.2023.2632
Article Number: 36
Copyright: © Furuya et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metaplastic breast carcinoma (MBC) is a heterogeneous group of invasive breast carcinomas (IBCs) characterized by the differentiation of the neoplastic epithelium toward squamous cells and/or mesenchymal‑appearing elements. The present study describes the case of a 42‑year‑old woman who underwent a mastectomy and sentinel lymph node biopsy for two tumors in their left breast. One of the resected tumors was diagnosed as MBC with neuroendocrine (NE) differentiation and the other was diagnosed as IBC of no special type. The MBC tumor contained a matrix composed of basal lamina with a focal area of myxoid matrix and squamoid differentiation. To the best of our knowledge, the present study is the first report of MBC producing prominent basal lamina. The patient has remained alive and well for >10 years without recurrence, and has been treated with oral and injected anticancer drugs.

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