Open Access

Gastric squamous cell carcinoma: A rare malignancy, literature review and management recommendations (Review)

  • Authors:
    • Glenn De Lange
    • Antonin Bouroumeau
    • Emmanuel Coron
    • Thibaud Koessler
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  • Published online on: August 30, 2023     https://doi.org/10.3892/mco.2023.2677
  • Article Number: 81
  • Copyright: © De Lange et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer serves a major role in the global cancer burden, being the fourth most frequent cause of mortality among all types of cancer. Gastric squamous cell carcinoma (GSCC) is a rare histological variant accounting for 0.04‑0.5% of all gastric cancer cases. Diagnostic work‑up of GSCC is essential and involves multiple criteria: i) Tumour not located in the cardia, ii) no oesophageal extension of the tumour, and iii) no evidence of SCC in any other part of the body. Little is known about this rare variant in terms of pathogenesis, risk factors or evolution. Consequently, neither the European Society of Medical Oncology nor the National Comprehensive Cancer Network societies have published recommendations for GSCC. The aim of the present review is to provide an in‑depth analysis of the current literature on this pathology, from pathophysiological hypothesis and clinical presentation to diagnostic work‑up and treatment trends, in order to establish a possible management algorithm.
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October-2023
Volume 19 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
De Lange G, Bouroumeau A, Coron E and Koessler T: Gastric squamous cell carcinoma: A rare malignancy, literature review and management recommendations (Review). Mol Clin Oncol 19: 81, 2023
APA
De Lange, G., Bouroumeau, A., Coron, E., & Koessler, T. (2023). Gastric squamous cell carcinoma: A rare malignancy, literature review and management recommendations (Review). Molecular and Clinical Oncology, 19, 81. https://doi.org/10.3892/mco.2023.2677
MLA
De Lange, G., Bouroumeau, A., Coron, E., Koessler, T."Gastric squamous cell carcinoma: A rare malignancy, literature review and management recommendations (Review)". Molecular and Clinical Oncology 19.4 (2023): 81.
Chicago
De Lange, G., Bouroumeau, A., Coron, E., Koessler, T."Gastric squamous cell carcinoma: A rare malignancy, literature review and management recommendations (Review)". Molecular and Clinical Oncology 19, no. 4 (2023): 81. https://doi.org/10.3892/mco.2023.2677