Open Access

Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review)

  • Authors:
    • Rayansh Poojary
    • Andy Fang Song
    • Benny Shone Song
    • Carly Shaw Song
    • Liqing Wang
    • Jianxun Song
  • View Affiliations

  • Published online on: October 12, 2023     https://doi.org/10.3892/mco.2023.2691
  • Article Number: 95
  • Copyright: © Poojary et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immunotherapy has emerged as a crucial treatment option, particularly for types of cancer that display resistance to conventional therapies. A remarkable breakthrough in this field is the development of chimeric antigen receptor (CAR) T cell therapy. CAR T cells are generated by engineering the T cells of a patient to express receptors that can recognize specific tumor antigens. This groundbreaking approach has demonstrated impressive outcomes in hematologic malignancies, including diffuse large B cell lymphoma, B cell acute lymphoblastic leukemia and multiple myeloma. Despite these significant successes, CAR T cell therapy has encountered challenges in its application against solid tumors, leading to limited success in these cases. Consequently, researchers are actively exploring novel strategies to enhance the efficacy of CAR T cells. The focus lies on augmenting CAR T cell trafficking to tumors while preventing the development of CAR T cell exhaustion and dysfunction. The present review aimed to provide a comprehensive analysis of the achievements and limitations of CAR T cell therapy in the context of cancer treatment. By understanding both the successes and hurdles, further advancements in this promising area of research can be developed. Overall, immunotherapy, particularly CAR T cell therapy, has opened up novel possibilities for cancer treatment, offering hope to patients with previously untreatable malignancies. However, to fully realize its potential, ongoing research and innovative strategies are essential in overcoming the challenges posed by solid tumors and maximizing CAR T cell efficacy in clinical settings.
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December-2023
Volume 19 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Poojary R, Song AF, Song BS, Song CS, Wang L and Song J: Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review). Mol Clin Oncol 19: 95, 2023.
APA
Poojary, R., Song, A.F., Song, B.S., Song, C.S., Wang, L., & Song, J. (2023). Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review). Molecular and Clinical Oncology, 19, 95. https://doi.org/10.3892/mco.2023.2691
MLA
Poojary, R., Song, A. F., Song, B. S., Song, C. S., Wang, L., Song, J."Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review)". Molecular and Clinical Oncology 19.6 (2023): 95.
Chicago
Poojary, R., Song, A. F., Song, B. S., Song, C. S., Wang, L., Song, J."Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review)". Molecular and Clinical Oncology 19, no. 6 (2023): 95. https://doi.org/10.3892/mco.2023.2691