Gastric cancer and brain metastasis: A systematic review and meta‑analysis
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- Published online on: August 19, 2024 https://doi.org/10.3892/mco.2024.2775
- Article Number: 77
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Copyright: © Fotakopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
Gastric cancer (GC) constitutes one of the most wide‑ranging cancers, with brain metastasis (BM) being a markedly uncommon and unfavorable outcome. The present meta‑analysis evaluated the relationship between no‑surgical treatment vs. additional surgical BM resection on the patient's quality of life and potential survival using electronic databases, including PubMed (1980‑April 2024), Medline (1980‑April 2024), Cochrane Library, and EMBASE (1980‑April 2024). After a literature search, six articles were included in the final study pool. The number of patients with BM and conservative treatment was 289 (80.05%) compared with those that underwent an additional surgical resection 72 (19.95%). The mean age was 59.2 years, and the males were 195 (73.8%) of 264 available from five studies. The findings of the present meta‑analysis revealed that the curative effect of BM tumor resection on patients with GC undergoing additional treatment with stereotactic radiosurgery, whole‑brain radiotherapy or chemotherapy was favorable for their survival.
