Unraveling the complex role of neutrophils in lymphoma: From pathogenesis to therapeutic approaches (Review)
- Authors:
- Ke Wang
- Xiao Wang
- Li Song
-
Affiliations: Department of Cell Engineering, School of Life Sciences and Biotechnology, Sanquan College of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China, Reproduction Medicine Center, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong 524002, P.R. China, Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Sanquan College of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China - Published online on: September 12, 2024 https://doi.org/10.3892/mco.2024.2783
- Article Number: 85
-
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Rapoport BL, Steel HC, Theron AJ, Smit T and Anderson R: Role of the neutrophil in the pathogenesis of advanced cancer and impaired responsiveness to therapy. Molecules. 25(1618)2020.PubMed/NCBI View Article : Google Scholar | |
Sounbuli K, Mironova N and Alekseeva L: diverse neutrophil functions in cancer and promising neutrophil-based cancer therapies. Int J Mol Sci. 23(15827)2022.PubMed/NCBI View Article : Google Scholar | |
Borregaard N: Neutrophils, from marrow to microbes. Immunity. 33:657–670. 2010.PubMed/NCBI View Article : Google Scholar | |
Nauseef WM and Borregaard N: Neutrophils at work. Nat Immunol. 15:602–611. 2014.PubMed/NCBI View Article : Google Scholar | |
Hidalgo A, Chilvers ER, Summers C and Koenderman L: The neutrophil life cycle. Trends Immunol. 40:584–597. 2019.PubMed/NCBI View Article : Google Scholar | |
Kolaczkowska E and Kubes P: Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 13:159–175. 2013.PubMed/NCBI View Article : Google Scholar | |
Ley K, Hoffman HM, Kubes P, Cassatella MA, Zychlinsky A, Hedrick CC and Catz SD: Neutrophils: New insights and open questions. Sci Immunol. 3(eaat4579)2018.PubMed/NCBI View Article : Google Scholar | |
Sionov RV, Fridlender ZG and Granot Z: The multifaceted roles neutrophils play in the tumor microenvironment. Cancer Microenviron. 8:125–158. 2015.PubMed/NCBI View Article : Google Scholar | |
Coffelt SB, Wellenstein MD and de Visser KE: Neutrophils in cancer: Neutral no more. Nat Rev Cancer. 16:431–446. 2016.PubMed/NCBI View Article : Google Scholar | |
Powell DR and Huttenlocher A: Neutrophils in the tumor microenvironment. Trends Immunol. 37:41–52. 2016.PubMed/NCBI View Article : Google Scholar | |
Mantovani A, Cassatella MA, Costantini C and Jaillon S: Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 11:519–531. 2011.PubMed/NCBI View Article : Google Scholar | |
Galdiero MR, Bonavita E, Barajon I, Garlanda C, Mantovani A and Jaillon S: Tumor associated macrophages and neutrophils in cancer. Immunobiology. 218:1402–1410. 2013.PubMed/NCBI View Article : Google Scholar | |
Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, Worthen GS and Albelda SM: Polarization of tumor-associated neutrophil phenotype by TGF-beta: ‘N1’ versus ‘N2’ TAN. Cancer Cell. 16:183–194. 2009.PubMed/NCBI View Article : Google Scholar | |
Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD and Jaffe ES: The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 127:2375–2390. 2016.PubMed/NCBI View Article : Google Scholar | |
Dhodapkar MV, Borrello I, Cohen AD and Stadtmauer EA: Hematologic malignancies: Plasma cell disorders. Am Soc Clin Oncol Educ Book. 37:561–568. 2017.PubMed/NCBI View Article : Google Scholar | |
Parente P, Zanelli M, Sanguedolce F, Mastracci L and Graziano P: Hodgkin Reed-Sternberg-like cells in non-hodgkin lymphoma. Diagnostics (Basel). 10(1019)2020.PubMed/NCBI View Article : Google Scholar | |
Armitage JO, Gascoyne RD, Lunning MA and Cavalli F: Non-Hodgkin lymphoma. Lancet. 390:298–310. 2017.PubMed/NCBI View Article : Google Scholar | |
Matasar MJ and Zelenetz AD: Overview of lymphoma diagnosis and management. Radiol Clin North Am. 46:175–198, vii. 2008.PubMed/NCBI View Article : Google Scholar | |
Xing AY, Dong XZ, Zhu LQ, Liu L, Sun D and Guo S: Clinicopathological characteristics and molecular phenotypes of primary hepatic lymphoma. Front Oncol. 12(906245)2022.PubMed/NCBI View Article : Google Scholar | |
Wang HW, Balakrishna JP, Pittaluga S and Jaffe ES: Diagnosis of Hodgkin lymphoma in the modern era. Br J Haematol. 184:45–59. 2019.PubMed/NCBI View Article : Google Scholar | |
Liew PX and Kubes P: The Neutrophil's role during health and disease. Physiol Rev. 99:1223–1248. 2019.PubMed/NCBI View Article : Google Scholar | |
Sureda A and Martinez C: Classical Hodgkin's lymphoma. In: The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies. Carreras E, Dufour C, Mohty M and Kroger N (eds): 7th edition. Springer, Cham, CH, pp653-662, 2019. | |
Euler M and Hoffmann MH: The double-edged role of neutrophil extracellular traps in inflammation. Biochem Soc Trans. 47:1921–1930. 2019.PubMed/NCBI View Article : Google Scholar | |
Pillay J, Kamp VM, van Hoffen E, Visser T, Tak T, Lammers JW, Ulfman LH, Leenen LP, Pickkers P and Koenderman L: A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest. 122:327–336. 2012.PubMed/NCBI View Article : Google Scholar | |
Upadhyay R, Hammerich L, Peng P, Brown B, Merad M and Brody JD: Lymphoma: Immune evasion strategies. Cancers (Basel). 7:736–762. 2015.PubMed/NCBI View Article : Google Scholar | |
Hirz T, Matera EL, Chettab K, Jordheim LP, Mathé D, Evesque A, Esmenjaud J, Salles G and Dumontet C: Neutrophils protect lymphoma cells against cytotoxic and targeted therapies through CD11b/ICAM-1 binding. Oncotarget. 8:72818–72834. 2017.PubMed/NCBI View Article : Google Scholar | |
Liu S, Wu W, Du Y, Yin H, Chen Q, Yu W, Wang W, Yu J, Liu L, Lou W and Pu N: The evolution and heterogeneity of neutrophils in cancers: Origins, subsets, functions, orchestrations and clinical applications. Mol Cancer. 22(148)2023.PubMed/NCBI View Article : Google Scholar | |
Wang X, Qiu L, Li Z, Wang XY and Yi H: Understanding the multifaceted role of neutrophils in cancer and autoimmune diseases. Front Immunol. 9(2456)2018.PubMed/NCBI View Article : Google Scholar | |
Heshmat-Ghahdarijani K, Sarmadi V, Heidari A, Falahati Marvasti A, Neshat S and Raeisi S: The neutrophil-to-lymphocyte ratio as a new prognostic factor in cancers: A narrative review. Front Oncol. 13(1228076)2023.PubMed/NCBI View Article : Google Scholar | |
Ohashi K, Nishito Y, Fukuda H, Sadahiro R, Yoshida Y, Watanabe SI, Motoi N, Sonobe Y, Mizuno H, Tsunoda H, et al: Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer. Sci Rep. 14(429)2024.PubMed/NCBI View Article : Google Scholar | |
Kim SI, Cassella CR and Byrne KT: Tumor burden and immunotherapy: Impact on immune infiltration and therapeutic outcomes. Front Immunol. 11(629722)2020.PubMed/NCBI View Article : Google Scholar | |
Pradeep U, Chiwhane A, Acharya S, Kumar S, Daiya V, Kasat PR, Gupta A and Bedi GN: The role of neutrophil-to-lymphocyte ratio in predicting outcomes of acute organophosphorus poisoning: A comprehensive review. Cureus. 16(e60854)2024.PubMed/NCBI View Article : Google Scholar | |
Zhang G, Yang C, Zhao C, Xian F, Qing D, Guo Q, Song J, Liu X and Bie J: Prognostic value of the neutrophil-to-lymphocyte ratio in patients treated with definitive chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma. Cancer Manag Res. 15:101–112. 2023.PubMed/NCBI View Article : Google Scholar | |
Masucci MT, Minopoli M and Carriero MV: Tumor associated neutrophils. Their role in tumorigenesis, metastasis, prognosis and therapy. Front Oncol. 9(1146)2019.PubMed/NCBI View Article : Google Scholar | |
Quintero-Fabian S, Arreola R, Becerril-Villanueva E, Torres-Romero JC, Arana-Argáez V, Lara-Riegos J, Ramírez-Camacho MA and Alvarez-Sánchez ME: Role of matrix metalloproteinases in angiogenesis and cancer. Front Oncol. 9(1370)2019.PubMed/NCBI View Article : Google Scholar | |
Christoffersson G, Vagesjo E, Vandooren J, Lidén M, Massena S, Reinert RB, Brissova M, Powers AC, Opdenakker G and Phillipson M: VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue. Blood. 120:4653–4662. 2012.PubMed/NCBI View Article : Google Scholar | |
Yu X, Li C, Wang Z, Xu Y, Shao S, Shao F, Wang H and Liu J: Neutrophils in cancer: Dual roles through intercellular interactions. Oncogene. 43:1163–1177. 2024.PubMed/NCBI View Article : Google Scholar | |
Kwantwi LB: Interplay between tumor-derived factors and tumor-associated neutrophils: Opportunities for therapeutic interventions in cancer. Clin Transl Oncol. 25:1963–1976. 2023.PubMed/NCBI View Article : Google Scholar | |
Xiong X, Liao X, Qiu S, Xu H, Zhang S, Wang S, Ai J and Yang L: CXCL8 in tumor biology and its implications for clinical translation. Front Mol Biosci. 9(723846)2022.PubMed/NCBI View Article : Google Scholar | |
Teijeira A, Garasa S, Ochoa MC, Villalba M, Olivera I, Cirella A, Eguren-Santamaria I, Berraondo P, Schalper KA, de Andrea CE, et al: IL8, Neutrophils, and NETs in a collusion against cancer immunity and immunotherapy. Clin Cancer Res. 27:2383–2393. 2021.PubMed/NCBI View Article : Google Scholar | |
De Meo ML and Spicer JD: The role of neutrophil extracellular traps in cancer progression and metastasis. Semin Immunol. 57(101595)2021.PubMed/NCBI View Article : Google Scholar | |
Huang X, Nepovimova E, Adam V, Sivak L, Heger Z, Valko M, Wu Q and Kuca K: Neutrophils in cancer immunotherapy: Friends or foes? Mol Cancer. 23(107)2024.PubMed/NCBI View Article : Google Scholar | |
Zhang Y, Guoqiang L, Sun M and Lu X: Targeting and exploitation of tumor-associated neutrophils to enhance immunotherapy and drug delivery for cancer treatment. Cancer Biol Med. 17:32–43. 2020.PubMed/NCBI View Article : Google Scholar | |
Armstrong H, Bording-Jorgensen M, Dijk S and Wine E: The Complex Interplay between chronic inflammation, the microbiome, and cancer: Understanding disease progression and what we can do to prevent it. Cancers (Basel). 10(83)2018.PubMed/NCBI View Article : Google Scholar | |
Wu TH, Hsieh SC, Li TH, Lu CH, Liao HT, Shen CY, Li KJ, Wu CH, Kuo YM, Tsai CY and Yu CL: Molecular basis for paradoxical activities of polymorphonuclear neutrophils in inflammation/anti-inflammation, bactericide/autoimmunity, pro-cancer/anticancer, and antiviral infection/SARS-CoV-II-induced immunothrombotic dysregulation. Biomedicines. 10(773)2022.PubMed/NCBI View Article : Google Scholar | |
Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell. 140:883–899. 2010.PubMed/NCBI View Article : Google Scholar | |
Coletto LA, Rizzo C, Guggino G, Caporali R, Alivernini S and D'Agostino MA: The role of neutrophils in spondyloarthritis: A journey across the spectrum of disease manifestations. Int J Mol Sci. 24(4108)2023.PubMed/NCBI View Article : Google Scholar | |
Herrero-Cervera A, Soehnlein O and Kenne E: Neutrophils in chronic inflammatory diseases. Cell Mol Immunol. 19:177–191. 2022.PubMed/NCBI View Article : Google Scholar | |
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X and Zhao L: Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9:7204–7218. 2017.PubMed/NCBI View Article : Google Scholar | |
Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y and Li Y: Inflammation and tumor progression: Signaling pathways and targeted intervention. Signal Transduct Target Ther. 6(263)2021.PubMed/NCBI View Article : Google Scholar | |
Xiong S, Dong L and Cheng L: Neutrophils in cancer carcinogenesis and metastasis. J Hematol Oncol. 14(173)2021.PubMed/NCBI View Article : Google Scholar | |
Rosales C: Neutrophil: A cell with many roles in inflammation or several cell types? Front Physiol. 9(113)2018.PubMed/NCBI View Article : Google Scholar | |
Tu Z, Zhong Y, Hu H, Shao D, Haag R, Schirner M, Lee J, Sullenger B and Leong KW: Design of therapeutic biomaterials to control inflammation. Nat Rev Mater. 7:557–574. 2022.PubMed/NCBI View Article : Google Scholar | |
Mata R, Yao Y, Cao W, Ding J, Zhou T, Zhai Z and Gao C: The dynamic inflammatory tissue microenvironment: Signality and disease therapy by biomaterials. Research (Wash D C). 2021(4189516)2021.PubMed/NCBI View Article : Google Scholar | |
Hannoodee S and Nasuruddin DN: Acute Inflammatory Response. StatPearls, Treasure Island, FL, 2023. | |
Ward PA and Lentsch AB: The acute inflammatory response and its regulation. Arch Surg. 134:666–669. 1999.PubMed/NCBI View Article : Google Scholar | |
Filep JG and Ariel A: Neutrophil heterogeneity and fate in inflamed tissues: Implications for the resolution of inflammation. Am J Physiol Cell Physiol. 319:C510–C532. 2020.PubMed/NCBI View Article : Google Scholar | |
Hirayama D, Iida T and Nakase H: The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis. Int J Mol Sci. 19(92)2017.PubMed/NCBI View Article : Google Scholar | |
Lawrence T and Gilroy DW: Chronic inflammation: A failure of resolution? Int J Exp Pathol. 88:85–94. 2007.PubMed/NCBI View Article : Google Scholar | |
Whiteside TL: The tumor microenvironment and its role in promoting tumor growth. Oncogene. 27:5904–5912. 2008.PubMed/NCBI View Article : Google Scholar | |
Megha KB, Joseph X, Akhil V and Mohanan PV: Cascade of immune mechanism and consequences of inflammatory disorders. Phytomedicine. 91(153712)2021.PubMed/NCBI View Article : Google Scholar | |
Zhang JM and An J: Cytokines, inflammation, and pain. Int Anesthesiol Clin. 45:27–37. 2007.PubMed/NCBI View Article : Google Scholar | |
Altan-Bonnet G and Mukherjee R: Cytokine-mediated communication: A quantitative appraisal of immune complexity. Nat Rev Immunol. 19:205–217. 2019.PubMed/NCBI View Article : Google Scholar | |
Fajgenbaum DC and June CH: Cytokine Storm. N Engl J Med. 383:2255–2273. 2020.PubMed/NCBI View Article : Google Scholar | |
Prame Kumar K, Nicholls AJ and Wong CHY: Partners in crime: Neutrophils and monocytes/macrophages in inflammation and disease. Cell Tissue Res. 371:551–565. 2018.PubMed/NCBI View Article : Google Scholar | |
Yang L, Shi P, Zhao G, Xu J, Peng W, Zhang J, Zhang G, Wang X, Dong Z, Chen F and Cui H: Targeting cancer stem cell pathways for cancer therapy. Signal Transduct Target Ther. 5(8)2020.PubMed/NCBI View Article : Google Scholar | |
Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002.PubMed/NCBI View Article : Google Scholar | |
Shao S, Miao H and Ma W: Unraveling the enigma of tumor-associated macrophages: Challenges, innovations, and the path to therapeutic breakthroughs. Front Immunol. 14(1295684)2023.PubMed/NCBI View Article : Google Scholar | |
Khilwani R and Singh S: Systems biology and cytokines potential role in lung cancer immunotherapy targeting autophagic axis. Biomedicines. 11(2706)2023.PubMed/NCBI View Article : Google Scholar | |
Yang L, Xie X, Tu Z, Fu J, Xu D and Zhou Y: The signal pathways and treatment of cytokine storm in COVID-19. Signal Transduct Target Ther. 6(255)2021.PubMed/NCBI View Article : Google Scholar | |
Anderson NM and Simon MC: The tumor microenvironment. Curr Biol. 30:R921–R925. 2020.PubMed/NCBI View Article : Google Scholar | |
Yan M, Zheng M, Niu R, Yang X, Tian S, Fan L, Li Y and Zhang S: Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications. Front Cell Dev Biol. 10(938289)2022.PubMed/NCBI View Article : Google Scholar | |
Xiao Y and Yu D: Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 221(107753)2021.PubMed/NCBI View Article : Google Scholar | |
Xiong T, He P, Zhou M, Zhong D, Yang T, He W, Xu Z, Chen Z, Liu YW and Dai SS: Glutamate blunts cell-killing effects of neutrophils in tumor microenvironment. Cancer Sci. 113:1955–1967. 2022.PubMed/NCBI View Article : Google Scholar | |
Giese MA, Hind LE and Huttenlocher A: Neutrophil plasticity in the tumor microenvironment. Blood. 133:2159–2167. 2019.PubMed/NCBI View Article : Google Scholar | |
Mantovani A and Allavena P: The interaction of anticancer therapies with tumor-associated macrophages. J Exp Med. 212:435–445. 2015.PubMed/NCBI View Article : Google Scholar | |
McFarlane AJ, Fercoq F, Coffelt SB and Carlin LM: Neutrophil dynamics in the tumor microenvironment. J Clin Invest. 131(e143759)2021.PubMed/NCBI View Article : Google Scholar | |
Galdiero MR, Garlanda C, Jaillon S, Marone G and Mantovani A: Tumor associated macrophages and neutrophils in tumor progression. J Cell Physiol. 228:1404–1412. 2013.PubMed/NCBI View Article : Google Scholar | |
Di Carlo E, Forni G, Lollini P, Colombo MP, Modesti A and Musiani P: The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood. 97:339–345. 2001.PubMed/NCBI View Article : Google Scholar | |
Li MY, Chong LC, Duns G, Lytle A, Woolcock B, Jiang A, Telenius A, Ben-Neriah S, Nawaz W, Slack GW, et al: TRAF3 loss-of-function reveals the noncanonical NF-κB pathway as a therapeutic target in diffuse large B cell lymphoma. Proc Natl Acad Sci USA. 121(e2320421121)2024.PubMed/NCBI View Article : Google Scholar | |
Mondragon L, Mhaidly R, De Donatis GM, Tosolini M, Dao P, Martin AR, Pons C, Chiche J, Jacquin M, Imbert V, et al: GAPDH Overexpression in the T cell lineage promotes angioimmunoblastic T cell lymphoma through an NF-κB-Dependent Mechanism. Cancer Cell. 36:268–287 e10. 2019.PubMed/NCBI View Article : Google Scholar | |
von Hoff L, Kargel E, Franke V, McShane E, Schulz-Beiss KW, Patone G, Schleussner N, Kolesnichenko M, Hübner N, Daumke O, et al: Autocrine LTA signaling drives NF-kappaB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma. Blood. 133:1489–1494. 2019.PubMed/NCBI View Article : Google Scholar | |
Gluud M, Pallesen EMH, Buus TB, Gjerdrum LMR, Lindahl LM, Kamstrup MR, Bzorek M, Danielsen M, Bech R, Monteiro MN, et al: Malignant T cells induce skin barrier defects through cytokine-mediated JAK/STAT signaling in cutaneous T-cell lymphoma. Blood. 141:180–193. 2023.PubMed/NCBI View Article : Google Scholar | |
Ramis-Zaldivar JE, Gonzalez-Farre B, Nicolae A, Pack S, Clot G, Nadeu F, Mottok A, Horn H, Song JY, Fu K, et al: MAPK and JAK-STAT pathways dysregulation in plasmablastic lymphoma. Haematologica. 106:2682–2693. 2021.PubMed/NCBI View Article : Google Scholar | |
Gehringer F, Weissinger SE, Moller P, Wirth T and Ushmorov A: Physiological levels of the PTEN-PI3K-AKT axis activity are required for maintenance of Burkitt lymphoma. Leukemia. 34:857–871. 2020.PubMed/NCBI View Article : Google Scholar | |
Takashima Y, Hayano A and Yamanaka R: Metabolome analysis reveals excessive glycolysis via PI3K/AKT/mTOR and RAS/MAPK signaling in methotrexate-resistant primary CNS Lymphoma-Derived Cells. Clin Cancer Res. 26:2754–2766. 2020.PubMed/NCBI View Article : Google Scholar | |
Wang G, Liu H, An L, Hou S and Zhang Q: CAPG facilitates diffuse large B-cell lymphoma cell progression through PI3K/AKT signaling pathway. Hum Immunol. 83:832–842. 2022.PubMed/NCBI View Article : Google Scholar | |
Sato A, Kamio N, Yokota A, Hayashi Y, Tamura A, Miura Y, Maekawa T and Hirai H: C/EBPβ isoforms sequentially regulate regenerating mouse hematopoietic stem/progenitor cells. Blood Adv. 4:3343–3356. 2020.PubMed/NCBI View Article : Google Scholar | |
Wang W, Xia X, Mao L and Wang S: The CCAAT/Enhancer-Binding protein family: Its Roles in MDSC expansion and function. Front Immunol. 10(1804)2019.PubMed/NCBI View Article : Google Scholar | |
Avellino R and Delwel R: Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation. Blood. 129:2083–2091. 2017.PubMed/NCBI View Article : Google Scholar | |
Hosokawa H, Koizumi M, Masuhara K, Romero-Wolf M, Tanaka T, Nakayama T and Rothenberg EV: Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells. J Exp Med. 218(e20202648)2021.PubMed/NCBI View Article : Google Scholar | |
Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, et al: Critical Roles for PU.1, GATA1, and GATA2 in the expression of human FcƐRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J Immunol. 192:3936–3946. 2014.PubMed/NCBI View Article : Google Scholar | |
Zakrzewska A, Cui C, Stockhammer OW, Benard EL, Spaink HP and Meijer AH: Macrophage-specific gene functions in Spi1-directed innate immunity. Blood. 116:e1–e11. 2010.PubMed/NCBI View Article : Google Scholar | |
Wu S, Wang H, Yang Q, Liu Z, Du J, Wang L, Chen S, Lu Q and Yang DH: METTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth. Cancer Lett. 597(217058)2024.PubMed/NCBI View Article : Google Scholar | |
Zhao A, Zhou H, Yang J, Li M and Niu T: Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies. Signal Transduct Target Ther. 8(71)2023.PubMed/NCBI View Article : Google Scholar | |
Zhuang S, Yang Z, Cui Z, Zhang Y and Che F: Epigenetic alterations and advancement of lymphoma treatment. Ann Hematol. 103:1435–1454. 2024.PubMed/NCBI View Article : Google Scholar | |
Tecchio C and Cassatella MA: Neutrophil-derived cytokines involved in physiological and pathological angiogenesis. Chem Immunol Allergy. 99:123–137. 2014.PubMed/NCBI View Article : Google Scholar | |
Shaul ME and Fridlender ZG: Neutrophils as active regulators of the immune system in the tumor microenvironment. J Leukoc Biol. 102:343–349. 2017.PubMed/NCBI View Article : Google Scholar | |
Jablonska J, Leschner S, Westphal K, Lienenklaus S and Weiss S: Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model. J Clin Invest. 120:1151–1164. 2010.PubMed/NCBI View Article : Google Scholar | |
Matta B, Battaglia J and Barnes BJ: Detection of neutrophil extracellular traps in patient plasma: Method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk. Front Immunol. 13(951254)2022.PubMed/NCBI View Article : Google Scholar | |
Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT and Wagner DD: Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci USA. 109:13076–13081. 2012.PubMed/NCBI View Article : Google Scholar | |
Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, Lohmeyer J and Preissner KT: Neutrophil extracellular traps directly induce epithelial and endothelial cell death: A predominant role of histones. PLoS One. 7(e32366)2012.PubMed/NCBI View Article : Google Scholar | |
Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, Weinrauch Y, Brinkmann V and Zychlinsky A: Novel cell death program leads to neutrophil extracellular traps. J Cell Biol. 176:231–241. 2007.PubMed/NCBI View Article : Google Scholar | |
Cools-Lartigue J, Spicer J, McDonald B, Gowing S, Chow S, Giannias B, Bourdeau F, Kubes P and Ferri L: Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest. 123:3446–3458. 2013.PubMed/NCBI View Article : Google Scholar | |
Berger-Achituv S, Brinkmann V, Abed UA, Kühn LI, Ben-Ezra J, Elhasid R and Zychlinsky A: A proposed role for neutrophil extracellular traps in cancer immunoediting. Front Immunol. 4(48)2013.PubMed/NCBI View Article : Google Scholar | |
Jehannin-Ligier K, Belot A, Guizard AV, Bossard N, Launoy G and Uhry Z: FRANCIM network. Incidence trends for potentially human papillomavirus-related and -unrelated head and neck cancers in France using population-based cancer registries data: 1980-2012. Int J Cancer. 140:2032–2039. 2017.PubMed/NCBI View Article : Google Scholar | |
Tohme S, Yazdani HO, Al-Khafaji AB, Chidi AP, Loughran P, Mowen K, Wang Y, Simmons RL, Huang H and Tsung A: Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress. Cancer Res. 76:1367–1380. 2016.PubMed/NCBI View Article : Google Scholar | |
Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, et al: Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 36:401–414. 2012.PubMed/NCBI View Article : Google Scholar | |
Brinkmann V and Zychlinsky A: Neutrophil extracellular traps: Is immunity the second function of chromatin? J Cell Biol. 198:773–783. 2012.PubMed/NCBI View Article : Google Scholar | |
Papayannopoulos V, Metzler KD, Hakkim A and Zychlinsky A: Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol. 191:677–691. 2010.PubMed/NCBI View Article : Google Scholar | |
Kaplan MJ and Radic M: Neutrophil extracellular traps: Double-edged swords of innate immunity. J Immunol. 189:2689–2695. 2012.PubMed/NCBI View Article : Google Scholar | |
Porto BN and Stein RT: Neutrophil extracellular traps in pulmonary diseases: Too much of a good thing? Front Immunol. 7(311)2016.PubMed/NCBI View Article : Google Scholar | |
Schonrich G, Raftery MJ and Samstag Y: Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression. Adv Biol Regul. 77(100741)2020.PubMed/NCBI View Article : Google Scholar | |
Cedervall J, Zhang Y, Huang H, Zhang L, Femel J, Dimberg A and Olsson AK: Neutrophil extracellular traps accumulate in peripheral blood vessels and compromise organ function in tumor-bearing animals. Cancer Res. 75:2653–2662. 2015.PubMed/NCBI View Article : Google Scholar | |
Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, et al: Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 361(eaao4227)2018.PubMed/NCBI View Article : Google Scholar | |
Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y and Wagner DD: Priming of neutrophils toward NETosis promotes tumor growth. Oncoimmunology. 5(e1134073)2016.PubMed/NCBI View Article : Google Scholar | |
Najmeh S, Cools-Lartigue J, Rayes RF, Gowing S, Vourtzoumis P, Bourdeau F, Giannias B, Berube J, Rousseau S, Ferri LE and Spicer JD: Neutrophil extracellular traps sequester circulating tumor cells via β1-integrin mediated interactions. Int J Cancer. 140:2321–2330. 2017.PubMed/NCBI View Article : Google Scholar | |
Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, et al: Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med. 8(361ra138)2016.PubMed/NCBI View Article : Google Scholar | |
Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN and Shapiro SD: Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med. 4:615–618. 1998.PubMed/NCBI View Article : Google Scholar | |
Geyer CE, Forster J, Lindquist D, Chan S, Romieu CG, Pienkowski T, Jagiello-Gruszfeld A, Crown J, Chan A, Kaufman B, et al: Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 355:2733–2743. 2006.PubMed/NCBI View Article : Google Scholar | |
Allen TM: Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer. 2:750–763. 2002.PubMed/NCBI View Article : Google Scholar | |
Mayadas TN, Cullere X and Lowell CA: The multifaceted functions of neutrophils. Annu Rev Pathol. 9:181–218. 2014.PubMed/NCBI View Article : Google Scholar | |
Nemeth T, Mocsai A and Lowell CA: Neutrophils in animal models of autoimmune disease. Semin Immunol. 28:174–186. 2016.PubMed/NCBI View Article : Google Scholar | |
Tecchio C, Micheletti A and Cassatella MA: Neutrophil-derived cytokines: Facts beyond expression. Front Immunol. 5(508)2014.PubMed/NCBI View Article : Google Scholar |