Open Access

Anti‑HER2‑targeted therapies for the treatment of advanced HER2‑positive breast cancer with brain metastases (Review)

  • Authors:
    • Zhangyan Wang
    • Huangming Hong
  • View Affiliations

  • Published online on: March 26, 2025     https://doi.org/10.3892/mco.2025.2840
  • Article Number: 45
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Compared with other metastatic sites, breast cancer brain metastases (BCBMs) are associated with the shortest survival time. In addition, human epidermal growth factor receptor 2 (HER2) is observed to be amplified in 20‑25% of breast cancer cases where it is a poor prognostic factor for brain metastases. Various anti‑HER2 targeted therapies have brought both new opportunities and challenges to patients with HER2‑positive BCBM over the past decade. However, prolonging survival time and improving quality of life of patients have become controversial issues in the field of clinical research on BCBMs. On the basis of the latest literature, the present review documents the anti‑HER2 targeted drugs applied in patients with HER2‑positive BCBM. Further studies on the efficacy and safety of novel HER2‑targeted drugs and combined or sequential therapy in clinical treatment are expected to provide more effective strategies for the treatment of patients with HER2‑positive BCBM.
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May-2025
Volume 22 Issue 5

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Z and Hong H: Anti‑HER2‑targeted therapies for the treatment of advanced HER2‑positive breast cancer with brain metastases (Review). Mol Clin Oncol 22: 45, 2025.
APA
Wang, Z., & Hong, H. (2025). Anti‑HER2‑targeted therapies for the treatment of advanced HER2‑positive breast cancer with brain metastases (Review). Molecular and Clinical Oncology, 22, 45. https://doi.org/10.3892/mco.2025.2840
MLA
Wang, Z., Hong, H."Anti‑HER2‑targeted therapies for the treatment of advanced HER2‑positive breast cancer with brain metastases (Review)". Molecular and Clinical Oncology 22.5 (2025): 45.
Chicago
Wang, Z., Hong, H."Anti‑HER2‑targeted therapies for the treatment of advanced HER2‑positive breast cancer with brain metastases (Review)". Molecular and Clinical Oncology 22, no. 5 (2025): 45. https://doi.org/10.3892/mco.2025.2840