Placental lesions in birth asphyxia and hypoxic ischemic syndrome

Calomfirescu‑Avramescu,Andreea; Ceauşelu,Luminiţa; Demetrian,Mihaela; Dima,Vlad; Bălănescu,Anca; Bălănescu,Paul; Mirea,Andrada; Toma,Adrian-Ioan; Șerboiu,Sorina Crenguța; Pătrașcu,Oana Maria; Al Jashi,Isam; Gherghina,Ioan

doi:10.3892/mi.2024.205

Placental lesions in birth asphyxia and hypoxic ischemic syndrome

Authors:
- Andreea Calomfirescu‑Avramescu
- Luminiţa Ceauşelu
- Mihaela Demetrian
- Vlad Dima
- Anca Bălănescu
- Paul Bălănescu
- Andrada Mirea
- Adrian-Ioan Toma
- Sorina Crenguța Șerboiu
- Oana Maria Pătrașcu
- Isam Al Jashi
- Ioan Gherghina
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Affiliations: Filantropia Clinical Hospital, 011132 Bucharest, Romania, Department of Pediatrics, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Neonatology, Faculty of Medicine, Titu Maiorescu University, 040441 Bucharest, Romania
Published online on: November 18, 2024 https://doi.org/10.3892/mi.2024.205
Article Number: 6
Copyright : © Calomfirescu‑Avramescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Birth asphyxia is a severe condition that includes a number of potential pathways of occurrence both in utero and during childbirth. The present study aimed to identify and describe specific macroscopic and microscopic placental injuries in birth asphyxia to serve as an effective tool to stratify the potential further evolution of a newborn, as hypoxic ischemic encephalopathy can be responsible for neonatal death or severe neurological sequelae further, compromising the quality of life of the affected individual. For this purpose, an observational prospective study was conducted over a period of 3 years. A total of 62 patients diagnosed with birth asphyxia, who had a placental histopathological examination performed were enrolled in the study. The control group consisted of 69 term newborns that required neonatal intensive care for at least 3 days, in the same time period, for any other reason and that also had available placental examinations. In the present study, placental histopathological lesions identified in birth asphyxia have been classified according to the Amsterdam Criteria. Data gathered from both groups were analyzed by applying specific statistical tests for each type of variable and hypothesis. Thus, umbilical cord abnormalities were associated with hypoxic ischemic encephalopathy in a statistically significant manner when comparing the birth asphyxia group of newborns with the control group. In addition, a high statistical level of significance was identified for microscopical lesions, such as maternal and fetal vascular malperfusion and the occurrence of hypoxic ischemic syndrome when comparing the two groups (P=0.01). The macroscopic and microscopic placental examination can provide critical information for the evolution of the disease in selected newborns according to the identified lesions.

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