Prognostic factors for first recurrence following meningioma surgery

Fotakopoulos,George; Georgakopoulou,Vasiliki Epameinondas; Spandidos,Demetrios A.; Angelopoulou,Efthalia; Menis,Apostolos-Alkiviadis; Trakas,Nikolaos; Alexiou,George; Voulgaris,Spyridon

doi:10.3892/mi.2024.213

Prognostic factors for first recurrence following meningioma surgery

Authors:
- George Fotakopoulos
- Vasiliki Epameinondas Georgakopoulou
- Demetrios A. Spandidos
- Efthalia Angelopoulou
- Apostolos-Alkiviadis Menis
- Nikolaos Trakas
- George Alexiou
- Spyridon Voulgaris
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Affiliations: Department of Neurosurgery, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Pathophysiology, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, 1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece, Intensive Care Unit, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece, Department of Neurosurgery, School of Medicine, University of Ioannina, 45500 Ioannina, Greece
Published online on: December 31, 2024 https://doi.org/10.3892/mi.2024.213
Article Number: 14
Copyright : © Fotakopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The present study investigated the role of the Simpson grade system, MIB‑1 immunohistochemical marker, meningioma location and grade in the risk of recurrence. Between January, 2008 and January, 2018, the present study retrospectively evaluated all patients undergoing craniotomy for the resection of a histopathologically confirmed meningioma. Patients with neurofibromatosis, acoustic neurinomas and radiation treatment prior to surgery were excluded. After applying the exclusion criteria, 103 patients were included in the study. Following a mean follow‑up period of 67.3±33 months, there were 12 cases (11.6%) of tumor recurrence. No significant association between meningioma recurrence and age, sex, or tumor location was found. When comparing the risk of recurrence between Simpson grades I, II, III and IV excisions, and between Simpson grade V, the difference was statistically significant. When comparing WHO grade I and II meningioma vs. grade III, the difference was significant. MIB‑1 LI >3% exhibited a trend towards a significant association with the risk of recurrence. On the whole, the present study demonstrates that the Simpson grade is associated with the risk of recurrence. Patients with tumors with an MIB‑1 index >3% may also be at a risk of recurrence. Notably, the present study proposed that in the case of recurrence, this is more likely to occur in an interval of 5.5 years following surgical intervention.

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1	Oya S, Kawai K, Nakatomi H and Saito N: Significance of Simpson grading system in modern meningioma surgery: Integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO grade I meningiomas. J Neurosurg. 117:121–128. 2012.PubMed/NCBI View Article : Google Scholar
2	Sughrue ME, Kane AJ, Shangari G, Rutkowski MJ, McDermott MW, Berger MS and Parsa AT: The relevance of Simpson Grade I and II resection in modern neurosurgical treatment of World Health Organization Grade I meningiomas. J Neurosurg. 113:1029–1035. 2010.PubMed/NCBI View Article : Google Scholar
3	Hasseleid BF, Meling TR, Rønning P, Scheie D and Helseth E: Surgery for convexity meningioma: Simpson grade I resection as the goal: Clinical article. J Neurosurg. 117:999–1006. 2012.PubMed/NCBI View Article : Google Scholar
4	Alvernia JE, Dang ND and Sindou MP: Convexity meningiomas: Study of recurrence factors with special emphasis on the cleavage plane in a series of 100 consecutive patients. J Neurosurg. 115:491–498. 2011.PubMed/NCBI View Article : Google Scholar
5	Aguiar PH, Tsanaclis AM, Tella OI Jr and Plese JP: Proliferation rate of intracranial meningiomas as defined by the monoclonal antibody MIB-1: Correlation with peritumoural oedema and other clinicoradiological and histological characteristics. Neurosurg Rev. 26:221–228. 2003.PubMed/NCBI View Article : Google Scholar
6	Amatya VJ, Takeshima Y, Sugiyama K, Kurisu K, Nishisaka T, Fukuhara T and Inai K: Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21WAF1, and p27KIP1 expression in benign, atypical, and anaplastic meningiomas. Hum Pathol. 32:970–975. 2001.PubMed/NCBI View Article : Google Scholar
7	Kasuya H, Kubo O, Tanaka M, Amano K, Kato K and Hori T: Clinical and radiological features related to the growth potential of meningioma. Neurosurg Rev. 29:293–296. 2006.PubMed/NCBI View Article : Google Scholar
8	Kim YJ, Ketter R, Steudel WI and Feiden W: Prognostic significance of the mitotic index using the mitosis marker anti-phosphohistone H3 in meningiomas. Am J Clin Pathol. 128:118–125. 2007.PubMed/NCBI View Article : Google Scholar
9	Colli BO, Carlotti CG Jr, Assirati JA Jr, Dos Santos MB, Neder L and Dos Santos AC: Parasagittal meningiomas: Follow-up review. Surg Neurol. 66 (Suppl 3):S20–S27. 2006.PubMed/NCBI View Article : Google Scholar
10	Durand A, Labrousse F, Jouvet A, Bauchet L, Kalamaridès M, Menei P, Deruty R, Moreau JJ, Fèvre-Montange M and Guyotat J: WHO grade II and III meningiomas: A study of prognostic factors. J Neurooncol. 95:367–375. 2009.PubMed/NCBI View Article : Google Scholar
11	Black PM, Morokoff AP and Zauberman J: Surgery for extra-axial tumors of the cerebral convexity and midline. Neurosurgery. 62 (Suppl 3):S1115–S1121. 2008.PubMed/NCBI View Article : Google Scholar
12	Celenk F, Erkilic S, Durucu C, Baysal E and Kanlikama M: Late metastasis of an intracranial meningioma to the hard palate. J Craniofac Surg. 23:1912–1914. 2012.PubMed/NCBI View Article : Google Scholar
13	Wang YC, Chuang CC, Wei KC, Hsu YH, Hsu PW, Lee ST, Wu CT, Tseng CK, Wang CC, Chen YL, et al: Skull base atypical meningioma: Long term surgical outcome and prognostic factors. Clin Neurol Neurosurg. 128:112–116. 2015.PubMed/NCBI View Article : Google Scholar
14	Ivan ME, Cheng JS, Kaur G, Sughrue ME, Clark A, Kane AJ, Aranda D, McDermott M, Barani IJ and Parsa AT: Association of morbidity with extent of resection and cavernous sinus invasion in sphenoid wing meningiomas. J Neurol Surg B Skull Base. 73:76–83. 2012.PubMed/NCBI View Article : Google Scholar
15	Bloch O, Sun M, Kaur G, Barani IJ and Parsa AT: Fractionated radiotherapy for optic nerve sheath meningiomas. J Clin Neurosci. 19:1210–1215. 2012.PubMed/NCBI View Article : Google Scholar
16	Zhang L, Wang Q, Zhu J and Luo C: A modified anterior petrosectomy approach for resection of petroclival meningioma; with management of complications. World Neurosurg. 187(101)2024.PubMed/NCBI View Article : Google Scholar
17	Bozkurt SU, Ayan E, Bolukbasi F, Elmaci I, Pamir N and Sav A: Immunohistochemical expression of SPARC is correlated with recurrence, survival and malignant potential in meningiomas. APMIS. 117:651–659. 2009.PubMed/NCBI View Article : Google Scholar
18	Krejchi D, Caldemeyer KS, Vakili ST and Pritz MB: Neurosarcoidosis resembling meningioma: MRI characteristics and pathologic correlation. J Neuroimaging. 8:177–179. 1998.PubMed/NCBI View Article : Google Scholar
19	Liu Y, Liu M, Li F, Wu C and Zhu S: Malignant meningiomas: A retrospective study of 22 cases. Bull Cancer. 94:E27–E31. 2007.PubMed/NCBI
20	Nakane Y, Natsume A, Wakabayashi T, Oi S, Ito M, Inao S, Saito K and Yoshida J: Malignant transformation-related genes in meningiomas: Allelic loss on 1p36 and methylation status of p73 and RASSF1A. J Neurosurg. 107:398–404. 2007.PubMed/NCBI View Article : Google Scholar
21	Rosenberg LA, Prayson RA, Lee J, Reddy C, Chao ST, Barnett GH, Vogelbaum MA and Suh JH: Long-term experience with World Health Organization grade III (malignant) meningiomas at a single institution. Int J Radiat Oncol Biol Phys. 74:427–432. 2009.PubMed/NCBI View Article : Google Scholar
22	Tao Y, Liang G, Li Z, Wang Y, Wu A, Wang H, Lu Y, Liu Z and Hu G: Clinical features and immunohistochemical expression levels of androgen, estrogen, progesterone and Ki-67 receptors in relationship with gross-total resected meningiomas relapse. Br J Neurosurg. 26:700–704. 2012.PubMed/NCBI View Article : Google Scholar
23	Jensen R and Lee J: Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia, vascularity, and proliferation. Neurosurgery. 71:146–156. 2012.PubMed/NCBI View Article : Google Scholar
24	Mukherjee S, Ghosh SN, Chatterjee U and Chatterjee S: Detection of progesterone receptor and the correlation with Ki-67 labeling index in meningiomas. Neurol India. 59:817–822. 2011.PubMed/NCBI View Article : Google Scholar
25	Jiang L, Wang T, Bao Y, Qian J, Wu XJ, Hu GH and Lu YC: A study of UbcH10 expression and its association with recurrence of meningiomas. J Surg Oncol. 106:327–331. 2012.PubMed/NCBI View Article : Google Scholar