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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-February 2008 Volume 1 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2008 Volume 1 Issue 1

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Article

Benefit from a high dose of gefitinib in a woman with lung adenocarcinoma and an epidermal growth factor receptor tyrosine-kinase acquired mutation

  • Authors:
    • Editta Baldini
    • Tiziana Prochilo
    • Laura Boldrini
    • Franca Melfi
    • Gabriella Fontanini

  • View Affiliations / Copyright

    Affiliations: Oncology Department, S. Chiara University Hospital, I-56132 Pisa, Italy. e.baldini@med.unipi.it
  • Pages: 41-43
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/mmr.1.1.41
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Abstract

Over the last 10 years, the approach to the treatment of cancer has changed significantly due to an improved understanding of the processes that regulate tumor growth and development. Targeted strategies act against various neoplasms, alone or in combination with conventional therapy, while avoiding most of the toxicities induced by standard chemotherapy and radiotherapy. Promising targets include members of the human epidermal receptor (HER) family, such as epidermal growth factor receptor (HER1/EGFR). Many EGFR-targeted agents, especially tyrosine-kinase inhibitors (TKIs), are being developed for the treatment of advanced non-small cell lung cancer (NSCLC) in which EGFR shows an activating mutation in the tyrosine-kinase domain. Mutations seem to be clinically relevant as they are most frequent in non-smokers, adenocarcinomas, women and Japanese patients, features related to a radiographic response to TKIs. Here, we report the management of a stage IV adenocarcinoma of the lung in a young non-smoking woman treated with gefitinib whose tumor developed EGFR-TKI resistance.

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Copy and paste a formatted citation
Spandidos Publications style
Baldini E, Prochilo T, Boldrini L, Melfi F and Fontanini G: Benefit from a high dose of gefitinib in a woman with lung adenocarcinoma and an epidermal growth factor receptor tyrosine-kinase acquired mutation. Mol Med Rep 1: 41-43, 2008.
APA
Baldini, E., Prochilo, T., Boldrini, L., Melfi, F., & Fontanini, G. (2008). Benefit from a high dose of gefitinib in a woman with lung adenocarcinoma and an epidermal growth factor receptor tyrosine-kinase acquired mutation. Molecular Medicine Reports, 1, 41-43. https://doi.org/10.3892/mmr.1.1.41
MLA
Baldini, E., Prochilo, T., Boldrini, L., Melfi, F., Fontanini, G."Benefit from a high dose of gefitinib in a woman with lung adenocarcinoma and an epidermal growth factor receptor tyrosine-kinase acquired mutation". Molecular Medicine Reports 1.1 (2008): 41-43.
Chicago
Baldini, E., Prochilo, T., Boldrini, L., Melfi, F., Fontanini, G."Benefit from a high dose of gefitinib in a woman with lung adenocarcinoma and an epidermal growth factor receptor tyrosine-kinase acquired mutation". Molecular Medicine Reports 1, no. 1 (2008): 41-43. https://doi.org/10.3892/mmr.1.1.41
Copy and paste a formatted citation
x
Spandidos Publications style
Baldini E, Prochilo T, Boldrini L, Melfi F and Fontanini G: Benefit from a high dose of gefitinib in a woman with lung adenocarcinoma and an epidermal growth factor receptor tyrosine-kinase acquired mutation. Mol Med Rep 1: 41-43, 2008.
APA
Baldini, E., Prochilo, T., Boldrini, L., Melfi, F., & Fontanini, G. (2008). Benefit from a high dose of gefitinib in a woman with lung adenocarcinoma and an epidermal growth factor receptor tyrosine-kinase acquired mutation. Molecular Medicine Reports, 1, 41-43. https://doi.org/10.3892/mmr.1.1.41
MLA
Baldini, E., Prochilo, T., Boldrini, L., Melfi, F., Fontanini, G."Benefit from a high dose of gefitinib in a woman with lung adenocarcinoma and an epidermal growth factor receptor tyrosine-kinase acquired mutation". Molecular Medicine Reports 1.1 (2008): 41-43.
Chicago
Baldini, E., Prochilo, T., Boldrini, L., Melfi, F., Fontanini, G."Benefit from a high dose of gefitinib in a woman with lung adenocarcinoma and an epidermal growth factor receptor tyrosine-kinase acquired mutation". Molecular Medicine Reports 1, no. 1 (2008): 41-43. https://doi.org/10.3892/mmr.1.1.41
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