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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2008 Volume 1 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Proteomic analysis of mucosal preparations from patients with ulcerative colitis

  • Authors:
    • Franz Fogt
    • Bo Jian
    • Rene C. Krieg
    • Axel Wellmann

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Penn Presbyterian Medical Center, University of Pennsylvania, Philadelphia, PA 19104, USA. franz.fogt@uphs.upenn.edu
  • Pages: 51-54
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/mmr.1.1.51
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Abstract

Proteomic profiling with the identification of molecular signatures is a powerful tool in the study of pathogenesis, and may allow us to predict the prognosis of disease states. In this study, mucosa/submucosa from the colonic resections of five patients with ulcerative colitis (UC) who had undergone colonic resection were microdisected. Proteins were separated by two-dimensional (2D) polyacrylamide gel electrophoresis. Proteins of interest were further extracted and identified by tryptic in-gel digestion and mass spectrometry. Among the proteins found were ones associated with inflammation and tissue repair, namely protocadherin, α-1 antitrypsin, tetratricopeptide repeat domains and caldesmon. Surprisingly, in all five cases specific spots were identified that represented mutated forms of desmin expressed in UC mucosa/submucosa (two spots were sequenced) and were verified with Western blotting. In summary, proteomic signature profiles of UC represent proteins associated with inflammation and repair. Mutated desmin may represent a specific protein associated with UC and may be used in the differential diagnosis of forms of inflammatory bowel disease (IBD).

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Copy and paste a formatted citation
Spandidos Publications style
Fogt F, Jian B, Krieg RC and Wellmann A: Proteomic analysis of mucosal preparations from patients with ulcerative colitis. Mol Med Rep 1: 51-54, 2008.
APA
Fogt, F., Jian, B., Krieg, R.C., & Wellmann, A. (2008). Proteomic analysis of mucosal preparations from patients with ulcerative colitis. Molecular Medicine Reports, 1, 51-54. https://doi.org/10.3892/mmr.1.1.51
MLA
Fogt, F., Jian, B., Krieg, R. C., Wellmann, A."Proteomic analysis of mucosal preparations from patients with ulcerative colitis". Molecular Medicine Reports 1.1 (2008): 51-54.
Chicago
Fogt, F., Jian, B., Krieg, R. C., Wellmann, A."Proteomic analysis of mucosal preparations from patients with ulcerative colitis". Molecular Medicine Reports 1, no. 1 (2008): 51-54. https://doi.org/10.3892/mmr.1.1.51
Copy and paste a formatted citation
x
Spandidos Publications style
Fogt F, Jian B, Krieg RC and Wellmann A: Proteomic analysis of mucosal preparations from patients with ulcerative colitis. Mol Med Rep 1: 51-54, 2008.
APA
Fogt, F., Jian, B., Krieg, R.C., & Wellmann, A. (2008). Proteomic analysis of mucosal preparations from patients with ulcerative colitis. Molecular Medicine Reports, 1, 51-54. https://doi.org/10.3892/mmr.1.1.51
MLA
Fogt, F., Jian, B., Krieg, R. C., Wellmann, A."Proteomic analysis of mucosal preparations from patients with ulcerative colitis". Molecular Medicine Reports 1.1 (2008): 51-54.
Chicago
Fogt, F., Jian, B., Krieg, R. C., Wellmann, A."Proteomic analysis of mucosal preparations from patients with ulcerative colitis". Molecular Medicine Reports 1, no. 1 (2008): 51-54. https://doi.org/10.3892/mmr.1.1.51
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