Adult mesenchymal stem cells in neural regeneration and repair: Current advances and future prospects (Review)

  • Authors:
    • Katarzyna A. Trzaska
    • Marianne D. Castillo
    • Pranela Rameshwar
  • View Affiliations

  • Published online on: May 1, 2008     https://doi.org/10.3892/mmr.1.3.307
  • Pages: 307-316
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mesenchymal stem cells (MSCs) are an attractive cell source for regenerative medicine as they can be easily isolated from bone marrow (BM) aspirates and expanded in culture while maintaining their ‘stemness’. In addition to differentiating into mesodermal cells, MSCs have shown considerable plasticity and generate ectodermal neurons and glia, which can be used to replace cells damaged by neurological diseases and injuries. These unique stem cells also exhibit immunomodulatory functions and secrete a variety of trophic factors which support regeneration and repair. This review focuses on the therapeutic usage of MSCs for neurodegenerative diseases and traumatic injuries to the nervous system. Animal studies demonstrate great promise for MSC transplantation in neurological disorders. In fact, a few clinical trials have already been initiated and show that MSCs are a safe cellular therapy and have great potential to become a viable treatment for neural disorders in the years to come.

Related Articles

Journal Cover

May-June 2008
Volume 1 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Trzaska KA, Castillo MD and Rameshwar P: Adult mesenchymal stem cells in neural regeneration and repair: Current advances and future prospects (Review). Mol Med Rep 1: 307-316, 2008.
APA
Trzaska, K.A., Castillo, M.D., & Rameshwar, P. (2008). Adult mesenchymal stem cells in neural regeneration and repair: Current advances and future prospects (Review). Molecular Medicine Reports, 1, 307-316. https://doi.org/10.3892/mmr.1.3.307
MLA
Trzaska, K. A., Castillo, M. D., Rameshwar, P."Adult mesenchymal stem cells in neural regeneration and repair: Current advances and future prospects (Review)". Molecular Medicine Reports 1.3 (2008): 307-316.
Chicago
Trzaska, K. A., Castillo, M. D., Rameshwar, P."Adult mesenchymal stem cells in neural regeneration and repair: Current advances and future prospects (Review)". Molecular Medicine Reports 1, no. 3 (2008): 307-316. https://doi.org/10.3892/mmr.1.3.307