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Combination of tamoxifen and antisense human telomerase RNA inhibits glioma cell proliferation and anti-apoptosis via suppression of telomerase activity

  • Authors:
    • Yingyi Wang
    • Zhimin Zhou
    • Hui Luo
    • Zhifeng Wu
    • Jiong Geng
    • Weifeng Miu
    • Yi Pu
    • Ning Liu
    • Yongping You
    • Zhengxiang Yang

  • View Affiliations

  • Published online on: September 1, 2010     https://doi.org/10.3892/mmr.2010.356
  • Pages: 935-940
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Accumulating evidence indicates that telomerase activity and human telomerase RNA (hTR) play a potentially crucial role in maintaining the malignant progression of human gliomas. Tamoxifen (TAM) induces cell growth inhibition by modulating several cellular activities, including signaling pathways and the cell cycle. In this study, we aimed to evaluate the effect of combination therapy with TAM and antisense hTR on malignant glioma growth in vitro. TAM treatment and the down-regulation of hTR expression by antisense hTR resulted in a significant suppression of cell growth and the induction of cell apoptosis through the inhibition of telomerase activity. The antitumor effect of treatment with TAM alone was found to be mediated in part by the down-regulation of telomerase activity and of PKC and IGF-1 expression. Our results indicate that TAM and antisense hTR may serve as a novel strategy for glioma therapy.

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November-December 2010
Volume 3 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
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Spandidos Publications style
Wang Y, Zhou Z, Luo H, Wu Z, Geng J, Miu W, Pu Y, Liu N, You Y, Yang Z, Yang Z, et al: Combination of tamoxifen and antisense human telomerase RNA inhibits glioma cell proliferation and anti-apoptosis via suppression of telomerase activity. Mol Med Rep 3: 935-940, 2010.
APA
Wang, Y., Zhou, Z., Luo, H., Wu, Z., Geng, J., Miu, W. ... Yang, Z. (2010). Combination of tamoxifen and antisense human telomerase RNA inhibits glioma cell proliferation and anti-apoptosis via suppression of telomerase activity. Molecular Medicine Reports, 3, 935-940. https://doi.org/10.3892/mmr.2010.356
MLA
Wang, Y., Zhou, Z., Luo, H., Wu, Z., Geng, J., Miu, W., Pu, Y., Liu, N., You, Y., Yang, Z."Combination of tamoxifen and antisense human telomerase RNA inhibits glioma cell proliferation and anti-apoptosis via suppression of telomerase activity". Molecular Medicine Reports 3.6 (2010): 935-940.
Chicago
Wang, Y., Zhou, Z., Luo, H., Wu, Z., Geng, J., Miu, W., Pu, Y., Liu, N., You, Y., Yang, Z."Combination of tamoxifen and antisense human telomerase RNA inhibits glioma cell proliferation and anti-apoptosis via suppression of telomerase activity". Molecular Medicine Reports 3, no. 6 (2010): 935-940. https://doi.org/10.3892/mmr.2010.356