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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2011 Volume 4 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2011 Volume 4 Issue 4

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Article

Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo

  • Authors:
    • Chun Jiang
    • Tan Tan
    • Xiao-Ping Yi
    • Hong Shen
    • Yi-Xiong Li

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Clinical Laboratory, The First People's Hospital of Chenzhou, Hunan 423000, P.R. China, Medical Research Center, Xiangya Hospital, Central South University, Hunan 410008, P.R. China
  • Pages: 667-674
    |
    Published online on: April 6, 2011
       https://doi.org/10.3892/mmr.2011.472
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Abstract

The aim of this study was to investigate the inhibitor of apoptosis proteins survivin and XIAP in pancreatic cancer by determining their biological characteristics and expression. XIAP and survivin are potential therapeutic targets for pancreatic cancer, and elucidating their association with cell proliferation and apoptosis may lead to the development of novel treatments for this disease. The human pancreatic cancer SW1990 cell line was infected with lentivirus and then analyzed by real-time PCR, and the results were confirmed by Western blotting. The MTT assay and the determination of caspase-3/-7 activity, DAPI-staining and tumorigenicity were used to measure cell proliferation and apoptosis in the human pancreatic cancer SW1990 cell line and in an experimental pancreatic cancer mouse xenograft model inoculated with the lentivirus-transfected SW1990 cells. The results revealed that the XIAP and survivin proteins were differentially expressed among the pancreatic cancer cell lines, and their decreased expression resulted in the inhibition of cell proliferation in vitro as well as in vivo. These findings suggest that lentivirus-mediated gene therapy targeting XIAP and survivin is a potential and attractive strategy for the treatment of pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Jiang C, Tan T, Yi X, Shen H and Li Y: Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo. Mol Med Rep 4: 667-674, 2011.
APA
Jiang, C., Tan, T., Yi, X., Shen, H., & Li, Y. (2011). Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo. Molecular Medicine Reports, 4, 667-674. https://doi.org/10.3892/mmr.2011.472
MLA
Jiang, C., Tan, T., Yi, X., Shen, H., Li, Y."Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo". Molecular Medicine Reports 4.4 (2011): 667-674.
Chicago
Jiang, C., Tan, T., Yi, X., Shen, H., Li, Y."Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo". Molecular Medicine Reports 4, no. 4 (2011): 667-674. https://doi.org/10.3892/mmr.2011.472
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang C, Tan T, Yi X, Shen H and Li Y: Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo. Mol Med Rep 4: 667-674, 2011.
APA
Jiang, C., Tan, T., Yi, X., Shen, H., & Li, Y. (2011). Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo. Molecular Medicine Reports, 4, 667-674. https://doi.org/10.3892/mmr.2011.472
MLA
Jiang, C., Tan, T., Yi, X., Shen, H., Li, Y."Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo". Molecular Medicine Reports 4.4 (2011): 667-674.
Chicago
Jiang, C., Tan, T., Yi, X., Shen, H., Li, Y."Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo". Molecular Medicine Reports 4, no. 4 (2011): 667-674. https://doi.org/10.3892/mmr.2011.472
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