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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2011 Volume 4 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells

  • Authors:
    • Koichi Nakamura
    • Yoshiaki Deyama
    • Yoshitaka Yoshimura
    • Masanori Hashimoto
    • Masayuki Kaga
    • Kuniaki Suzuki
    • Yasutaka Yawaka

  • View Affiliations / Copyright

    Affiliations: Department of Dentistry for Children and Disabled Persons, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan, Department of Molecular Cell Pharmacology, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan, Department of Biomaterials and Bioengineering, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu 061-0293, Japan
  • Pages: 641-644
    |
    Published online on: April 15, 2011
       https://doi.org/10.3892/mmr.2011.476
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Abstract

Glass ionomer cements (GICs) are widely used for the operative restoration of dental caries. However, it has been reported that the components of GICs cause pulpal inflammatory responses. Recently, GICs containing tannin-fluoride preparation (HY agent) were developed. In this study, we investigated the effect of HY agent on prostaglandin E2 (PGE2) release from GIC-stimulated rat dental pulp cells (RPC-C2A). Extracts derived from GIC disks were used with HY(+) and without HY(-) agent. After treatment with GIC extracts, ATP contents, COX-2 mRNA and protein expression in RPC-C2A cells, and PGE2 production in culture media were analyzed. HY agent suppressed HY(-)-stimulated PGE2 release from RPC-C2A cells, as well as COX-2 mRNA and protein expression. Moreover, tannic acid attenuated COX-2 mRNA induced by HY(-) extract in a dose-dependent manner. Taken together, these results suggest that tannic acid in HY agent may suppress GIC-induced production of PGE2 by inhibition of COX-2 expression in dental pulp cells.

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Copy and paste a formatted citation
Spandidos Publications style
Nakamura K, Deyama Y, Yoshimura Y, Hashimoto M, Kaga M, Suzuki K and Yawaka Y: Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells. Mol Med Rep 4: 641-644, 2011.
APA
Nakamura, K., Deyama, Y., Yoshimura, Y., Hashimoto, M., Kaga, M., Suzuki, K., & Yawaka, Y. (2011). Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells. Molecular Medicine Reports, 4, 641-644. https://doi.org/10.3892/mmr.2011.476
MLA
Nakamura, K., Deyama, Y., Yoshimura, Y., Hashimoto, M., Kaga, M., Suzuki, K., Yawaka, Y."Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells". Molecular Medicine Reports 4.4 (2011): 641-644.
Chicago
Nakamura, K., Deyama, Y., Yoshimura, Y., Hashimoto, M., Kaga, M., Suzuki, K., Yawaka, Y."Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells". Molecular Medicine Reports 4, no. 4 (2011): 641-644. https://doi.org/10.3892/mmr.2011.476
Copy and paste a formatted citation
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Spandidos Publications style
Nakamura K, Deyama Y, Yoshimura Y, Hashimoto M, Kaga M, Suzuki K and Yawaka Y: Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells. Mol Med Rep 4: 641-644, 2011.
APA
Nakamura, K., Deyama, Y., Yoshimura, Y., Hashimoto, M., Kaga, M., Suzuki, K., & Yawaka, Y. (2011). Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells. Molecular Medicine Reports, 4, 641-644. https://doi.org/10.3892/mmr.2011.476
MLA
Nakamura, K., Deyama, Y., Yoshimura, Y., Hashimoto, M., Kaga, M., Suzuki, K., Yawaka, Y."Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells". Molecular Medicine Reports 4.4 (2011): 641-644.
Chicago
Nakamura, K., Deyama, Y., Yoshimura, Y., Hashimoto, M., Kaga, M., Suzuki, K., Yawaka, Y."Tannin-fluoride preparation attenuates prostaglandin E2 production by dental pulp cells". Molecular Medicine Reports 4, no. 4 (2011): 641-644. https://doi.org/10.3892/mmr.2011.476
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