Anti-aging effects of extracts prepared from salmon nasal cartilage in hairless mice

Goto,Masashi; Ito,Seiko; Kato,Yoji; Yamazaki,Shota; Yamamoto,Kazushi; Katagata,Yohtaro

doi:10.3892/mmr.2011.498

Anti-aging effects of extracts prepared from salmon nasal cartilage in hairless mice

Authors:
- Masashi Goto
- Seiko Ito
- Yoji Kato
- Shota Yamazaki
- Kazushi Yamamoto
- Yohtaro Katagata
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Affiliations: Science of Bioresources, The United Graduate School of Agricultural Sciences, Iwate University, Morioka 020-8550, Japan, Laboratory of Food Science, Faculty of Education, Hirosaki University, Hirosaki 036-8560, Japan, Department of Biochemistry and Biotechnology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki 036-8561, Japan, R&D Department, Sunstar Inc., Takatsuki 569-1195, Japan
Published online on: May 23, 2011 https://doi.org/10.3892/mmr.2011.498
Pages: 779-784

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Abstract

The skin anti-aging effects of orally administered salmon nasal cartilage extract (SNCE), which includes abundant proteoglycan, were investigated using a hairless mouse skin-aging model, in which aging was caused by repetitive ultraviolet B (UV-B) irradiation. Physiological analysis of the skin surface following repetitive UV-B irradiation of 8 weeks revealed inhibition of erythema levels and reduction of transepidermal water loss (TEWL) due to oral administration of SNCE. Similarly, inhibitory actions of epidermal and dermal hypertrophy were revealed by hematoxylin and eosin staining. Furthermore, effects on the hydration level of the skin surface by SNCE administration were indicated at 4 weeks of UV-B irradiation, but greater effects were not apparent. These results indicate that SNCE may serve as an anti-aging agent for healthy skin.