Increased sTREM-1 in pregnant women with premature rupture of membranes and subclinical chorioamnionitis

  • Authors:
    • Jianping Wang
    • Yiji Zhang
    • hanqing Zhang
    • Wanglei  Qu
    • Jieqiang Lv
    • Yuhuan Wang
    • Jian Xiao
  • View Affiliations

  • Published online on: December 13, 2011     https://doi.org/10.3892/mmr.2011.710
  • Pages: 663-667
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Abstract

Premature rupture of membranes (PROM) is a common obstetric complication frequently occurring with concomitant chorioamnionitis. The present study aimed to evaluate levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in serum and amniotic fluid in pregnant women with PROM and to compare sTREM-1 with the commonly used laboratory indicators, serum C-reactive protein (CRP) and white blood cell (WBC) count. A total of 55 pregnant women with PROM were enrolled. Their venous blood and amniotic fluid were collected at delivery. sTREM-1 concentrations in the serum and amniotic fluid were determined by enzyme-linked immunosorbent assay. The measured data were compared with the pathological results of the placenta and fetal membrane. Meanwhile, sTREM-1 was compared with the laboratory indicators, serum CRP and WBC count. Serum and amniotic fluid sTREM-1 levels were significantly higher in pregnant women with subclinical chorioamnionitis compared to pregnant women without chorioamnionitis. Serum concentration of sTREM-1 yielded a sensitivity of 81.8% and a specificity of 77.3% for the prediction of subclinical chorioamnionitis. The amniotic fluid concentration of sTREM-1 resulted in a sensitivity of 81.8% and a specificity of 86.4% for the prediction of subclinical chorioamnionitis. In conclusion, serum and amniotic fluid sTREM-1 levels may emerge as early biological indicators for predicting PROM complicated with subclinical chorioamnionitis. sTREM-1 levels are superior to WBC count in predicting subclinical chorioamnionitis.

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March 2012
Volume 5 Issue 3

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Spandidos Publications style
Wang J, Zhang Y, Zhang h, Qu W, Lv J, Wang Y and Xiao J: Increased sTREM-1 in pregnant women with premature rupture of membranes and subclinical chorioamnionitis. Mol Med Rep 5: 663-667, 2012.
APA
Wang, J., Zhang, Y., Zhang, h., Qu, W., Lv, J., Wang, Y., & Xiao, J. (2012). Increased sTREM-1 in pregnant women with premature rupture of membranes and subclinical chorioamnionitis. Molecular Medicine Reports, 5, 663-667. https://doi.org/10.3892/mmr.2011.710
MLA
Wang, J., Zhang, Y., Zhang, h., Qu, W., Lv, J., Wang, Y., Xiao, J."Increased sTREM-1 in pregnant women with premature rupture of membranes and subclinical chorioamnionitis". Molecular Medicine Reports 5.3 (2012): 663-667.
Chicago
Wang, J., Zhang, Y., Zhang, h., Qu, W., Lv, J., Wang, Y., Xiao, J."Increased sTREM-1 in pregnant women with premature rupture of membranes and subclinical chorioamnionitis". Molecular Medicine Reports 5, no. 3 (2012): 663-667. https://doi.org/10.3892/mmr.2011.710