TP53 gene deletion in esophageal cancer tissues of patients and its clinical significance

  • Authors:
    • Madiniyet Niyaz
    • Abdugheni Turghun
    • Zhang Hai Ping
    • Zhang Zhu
    • Ilyar Sheyhedin
    • Cai Ren
    • Idiris Awut
  • View Affiliations

  • Published online on: November 1, 2012     https://doi.org/10.3892/mmr.2012.1162
  • Pages: 122-126
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Abstract

The aim of this study was to examine TP53 gene deletion in esophageal cancer (EC) tissues obtained from patients and to evaluate its clinical significance. Forty surgical specimens from patients with esophageal squamous cell carcinoma were examined for TP53 gene deletion using the fluorescence in situ hybridization (FISH) technique. Thirty-two male and 8 female patients were enrolled, with an average age of 56 years. TP53 gene deletion was significantly higher in poorly-differentiated EC cases compared to well-differentiated cases (P=0.028). The TP53 gene deletion rate was also significantly higher in the group with lymph node metastasis compared to the group without lymph node metastasis (P=0.0313). The TP53 gene deletion rate was shown to be correlated with the level of differentiation and lymph node metastasis in EC; it may therefore be an important molecular marker for evaluating the condition of EC in patients.
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January 2013
Volume 7 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Niyaz M, Turghun A, Ping ZH, Zhu Z, Sheyhedin I, Ren C and Awut I: TP53 gene deletion in esophageal cancer tissues of patients and its clinical significance. Mol Med Rep 7: 122-126, 2013
APA
Niyaz, M., Turghun, A., Ping, Z.H., Zhu, Z., Sheyhedin, I., Ren, C., & Awut, I. (2013). TP53 gene deletion in esophageal cancer tissues of patients and its clinical significance. Molecular Medicine Reports, 7, 122-126. https://doi.org/10.3892/mmr.2012.1162
MLA
Niyaz, M., Turghun, A., Ping, Z. H., Zhu, Z., Sheyhedin, I., Ren, C., Awut, I."TP53 gene deletion in esophageal cancer tissues of patients and its clinical significance". Molecular Medicine Reports 7.1 (2013): 122-126.
Chicago
Niyaz, M., Turghun, A., Ping, Z. H., Zhu, Z., Sheyhedin, I., Ren, C., Awut, I."TP53 gene deletion in esophageal cancer tissues of patients and its clinical significance". Molecular Medicine Reports 7, no. 1 (2013): 122-126. https://doi.org/10.3892/mmr.2012.1162